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Casgevy
Exagamglogene Autotemcel
EXAGAMGLOGENE AUTOTEMCEL treats sickle cell disease. It may also be used to treat beta thalassemia. It works by helping your body make healthy red blood cells. These cells do not sickle. This can reduce symptoms of sickle cell disease, such as pain crises. Healthy red blood cells also reduce the need for blood transfusions in people with beta thalassemia. Compare gene therapy drugs.
Prescription Settings
Biologic Drug: Biologic drugs are made from living cells and are often expensive. Because biologic drugs are difficult to copy, they typically don’t have generic alternatives available. Learn More.

What is Casgevy?

What should I tell my doctor?

They need to know if you have any of these conditions:

  • Hepatitis
  • HIV or AIDS
  • Recent or upcoming vaccine
  • An unusual or allergic reaction to exagamglogene autotemcel, other medications, foods, dyes, or preservatives
  • If you or your partner are pregnant or trying to get pregnant
  • Breastfeeding

How should I use this drug?

This medication is infused into a vein. It is given by your care team in a hospital or clinic setting.

This therapy uses your own stem cells. Your care team will give you other medications as part of your treatment. Before therapy, your care team will give you a medication that helps move your stem cells from your bone marrow to the blood stream, so they can collect them. This is called mobilization. These cells will be used to make your treatment. Shortly before you receive treatment, you will receive another medication that helps prepare your body for the stem cell transplant. This is called conditioning.

Talk to your care team about the use of this medication in children. While it may be given to children as young as 12 years for selected conditions, precautions do apply.

What if I miss a dose?

This does not apply. This medication is not for regular use.

Where should I store this drug?

This medication is given in a hospital or clinic. It will not be stored at home.

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