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Capecitabine Coupon - Capecitabine 500mg tablet

capecitabine

Generic Xeloda
Used for Breast Cancer, Colon Cancer
Used for Breast Cancer, Colon Cancer

Capecitabine (Xeloda) is an antimetabolite chemotherapy medication. It's used to treat many different types of cancer, including colorectal cancer, breast cancer, and pancreatic cancer. Capecitabine (Xeloda) prevents cancer cells from spreading by interfering with the genetic material. This medication is taken by mouth, typically twice daily, within 30 minutes of a meal. Some of the more common side effects of capecitabine (Xeloda) include hand-and-foot syndrome (a skin reaction) and serious diarrhea.

Reviewed by:
reviewer
Allison Baxley, PharmD, BCOP
reviewer
Connie Zheng, PharmD
Last reviewed on January 25, 2024
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageInteractionsCostContraindicationsAlternativesLatest newsImagesReferencesPricesMedicare
basics-icon

What is Capecitabine (Xeloda)?

What is Capecitabine (Xeloda) used for?

How Capecitabine (Xeloda) works

Capecitabine (Xeloda) is an antimetabolite chemotherapy. Once it gets inside the body, capecitabine (Xeloda) is converted into fluorouracil, which is the active form of this medication. It prevents cells from making the genetic material needed to grow and multiply. Because cancer cells tend to grow much faster than healthy cells, fluorouracil ends up affecting cancer cells more. As a result, cancer cells can’t grow and spread as well.

Drug Facts

Common BrandsXeloda
Drug ClassAntimetabolite
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
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What are the side effects of Capecitabine (Xeloda)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Hand-and-foot syndrome (up to 60%)
  • Diarrhea (up to 55%)
  • Nausea (up to 43%)
  • Fatigue or tiredness (up to 42%%)
  • Stomach pain (up to 35%)
  • Vomiting (up to 27%)
  • Open mouth sores (up to 25%)
Note: Side effects were reported by people who took capecitabine (Xeloda) for colon or colorectal cancer.

Other Side Effects

  • Constipation
  • Change in taste
  • Hair loss
  • Dizziness
  • Headache
  • Fever
  • Rash
  • Swelling
  • Pain
  • Trouble catching your breath
  • Eye irritation

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Severe diarrhea or blood in your stool
  • Severe skin reactions: rash, blisters, peeling skin, painful swelling
  • Heart problems: heart attack, chest pain, abnormal heart rhythm

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Abdominal or stomach pain

diarrhea

loss of fingerprints

nausea

numbness, pain, tingling, or other unusual sensations in the palms of the hands or bottoms of the feet

pain, blistering, peeling, redness, or swelling of the palms of the hands or bottoms of the feet

pain, redness, swelling, sores, or ulcers in your mouth or on your lips

unusual tiredness or weakness

vomiting

Less common or rare

Abdominal or stomach cramping or pain (severe)

agitation

back pain

bleeding and bruising

bleeding gums

blood in the urine or stools

bloody nose

bloody or black, tarry stools

blurred vision

burning, dry, or itching eyes

chest pain

chills

clumsiness or unsteadiness

cold

collapse

coma

confusion

constipation

convulsions

cough or hoarseness (accompanied by fever or chills)

cough producing mucus

coughing or spitting up blood

dark urine

decreased frequency or amount of urine

difficulty with breathing

difficulty with swallowing or pain in the back of throat or chest when swallowing

discharge from the eyes

drowsiness

dry mouth

excessive tearing

extra heartbeats

eye redness, irritation, or pain

fainting

fast or irregular heartbeat

fever or chills

flu-like symptoms

hallucinations

headache, sudden and severe

heavier menstrual periods

high fever

hot, red skin on the feet or legs

inability to speak

increased menstrual flow or vaginal bleeding

increased thirst

irritability

itching in the genital or other skin areas

lightheadedness

light-colored stools

loss of consciousness

lower back or side pain (accompanied by fever or chills)

muscle aches or cramps

muscle spasms

nosebleeds

numbness or tingling in the hands, feet, or lips

painful or difficult urination (accompanied by fever or chills)

painful, swollen feet or legs

pain, tenderness, or swelling in the upper abdominal or stomach area

pale skin

paralysis

pinpoint red spots on the skin

problems with coordination

prolonged bleeding from cuts

rapid, shallow breathing

red or dark brown urine

redness, pain, or swelling of the eye, eyelid, or inner lining of the eyelid

scaling

seizures

severe constipation

skin rash or itching

slow or irregular heartbeat

slurred speech

sneezing, sore throat, or stuffy nose

sores, ulcers, or white spots on the lips or in the mouth

stiff neck

stomach bloating, burning, or cramping

swelling of the face, fingers, feet, or lower legs

swelling of the lymph nodes

swollen glands

temporary blindness

tiredness or weakness

trouble with speaking

troubled breathing or tightness in the chest

unexplained nosebleeds

unusual bleeding or bruising

unusual lump or swelling in the chest

vomiting blood or material that looks like coffee grounds

weakness in the arm or leg on one side of the body, sudden and severe

weight gain or loss

white patches in the mouth or throat or on the tongue

white patches with diaper rash

yellow eyes or skin

Incidence not known

Chest discomfort, tightness, or heaviness

dilated neck veins

dizziness

extreme fatigue

irregular breathing

no blood pressure or pulse

pain or discomfort in the arms, jaw, back, or neck

stopping of heart

sweating

unconsciousness

weight gain

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings

changes or discoloration in the fingernails or toenails

difficulty with moving

discouragement

headache

heartburn

increased sensitivity of the skin to sunlight

muscle pain

pain

pain and redness of the skin at the place of x-ray treatment

pain in the joints or limbs

red, sore eyes

sunken eyes

thirst

trouble sleeping

weakness

wrinkled skin

Rare

Bone pain

change in color of treated skin

difficulty with walking

discouragement

feeling of constant movement of self or surroundings

feeling sad or empty

full or bloated feeling or pressure in the stomach

general feeling of discomfort or illness

hot flushes

impaired balance

increased sweating

joint pain

lack of appetite

loss of interest or pleasure

muscle weakness

noisy breathing

pain in the rectum

pain, swelling, or redness in the joints

passing less gas

rough, scratchy sound to voice

runny nose

sensation of spinning

shakiness in the legs, arms, hands, or feet

shivering

sores on the skin

swelling of abdominal or stomach area

tremor or shaking of the hands or feet

trouble concentrating

voice changes

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Capecitabine (Xeloda)

thumbs-up

Pros

Taken by mouth

Doesn't cause as much hair loss as similar chemotherapies

Available as a lower-cost generic medication

thumbs-down

Cons

Taken twice daily

Need to take within 30 minutes after a meal

Must use birth control while taking since it can cause harm to an unborn baby

pharmacist-tips

Pharmacist tips for Capecitabine (Xeloda)

pharmacist

  • Create a calendar or use an app on your phone to keep track of when you should take your medications. Capecitabine (Xeloda) and many chemotherapy medications are taken in cycles to lower the risk of side effects.

    • Swallow the capecitabine (Xeloda) tablets whole with water within 30 minutes after a meal.

      • Don't crush or cut the capecitabine (Xeloda) tablets. The powder from crushed tablets can cause problems to you or other people who live in your house.

        • Diarrhea is a common side effect of capecitabine (Xeloda). Contact your provider if you have diarrhea. If your symptoms are mild, they might recommend you take an over-the-counter medication, such as loperamide (Imodium) to help. Seek medical help right away if you experience severe bloody diarrhea, stomach pain, and fever.

          • Capecitabine (Xeloda) sometimes causes a side effect called hand-foot syndrome (HFS), which is a skin condition on the palms of your hands and soles of your feet. To help prevent HFS, avoid hot showers and washing your hands with hot water. Wear comfortable, loose-fitting shoes and apply lotion to your hands and feet every day.

            • Make sure to stay hydrated by drinking plenty of fluids throughout the day while taking capecitabine (Xeloda). Dehydration can lead to kidney problems, which can be serious.

              • Capecitabine (Xeloda) can harm an unborn baby. If you’re a female able to have babies, you should use effective birth control while taking capecitabine (Xeloda) and for 6 months after the last dose. If you’re a male who is sexually active with a female able to have babies, you should use effective birth control, such as condoms, while taking capecitabine (Xeloda) and for 3 months after the last dose.

                • If you're also taking warfarin (Coumadin), let your warfarin (Coumadin) clinic know you're going to start taking capecitabine (Xeloda). This medication can interact with your blood thinner and cause you to bleed more easily. Because of this, your clinic might want to monitor your warfarin (Coumadin) therapy more closely.

                  • We don’t know if capecitabine (Xeloda) passes into human milk. But it does, there's a chance that it can harm a nursing infant. Because of this, your provider will ask you to avoid breastfeed while taking capecitabine (Xeloda) and for 1 week after the last dose.

                    faqs

                    Frequently asked questions about Capecitabine (Xeloda)

                    Is capecitabine (Xeloda) a chemotherapy medication?
                    Yes, capecitabine (Xeloda) is a chemotherapy medication. Generally, chemotherapy medications attack cells that are growing very quickly. Because cancer cells grow faster than healthy cells, chemotherapy typically works well to attack cancer cells. But, there are also certain cells in your body that are healthy and grow quickly, such as your blood cells and your hair cells. This is why most people experience side effects, such as low blood cells and hair loss, when they take chemotherapy, because the chemotherapy also affects some healthy cells in addition to attacking cancer cells.
                    How long does it take for capecitabine (Xeloda) to start working?
                    The time it takes for capecitabine (Xeloda) to work can differ for each person. It depends on several factors, such as the type of cancer you have and if you’re taking capecitabine (Xeloda) by itself or together with radiation or other chemotherapy medications. Your provider will monitor how well capecitabine (Xeloda) treats your cancer with lab tests, scans, and your symptoms. If you're concerned about whether capecitabine (Xeloda) is working for you, discuss it with your provider.
                    How long does capecitabine (Xeloda) stay in your system?
                    Capecitabine (Xeloda) doesn’t stay in your body very long. After one dose, it’s typically out of your system within 5 hours (based on the half-life of this medication). This is why you need to take capecitabine (Xeloda) twice a day. But because capecitabine (Xeloda) leaves the body through the kidneys, it’ll likely stay in your system longer if you’ve kidney problems. If that’s the case, your provider might need to adjust your dose and monitor you closely during your treatment.
                    Does capecitabine (Xeloda) cause hair loss?
                    When capecitabine (Xeloda) is taken by itself, hair loss isn’t a common side effect. But, sometimes capecitabine (Xeloda) is taken together with other chemotherapy medications, and sometimes those other medications might cause hair loss. If you have hair loss, let your provider know and they can talk with you about your options. Usually, hair will grow back after chemotherapy is stopped.
                    What are the most common side effects of capecitabine (Xeloda)?
                    Some of the most common side effects of capecitabine (Xeloda) include diarrhea and a skin condition called hand-foot syndrome (HFS). If you experience diarrhea while taking capecitabine (Xeloda), let your provider know. They might recommend an over-the-counter medication such as loperamide (Imodium), or a prescription medication such as diphenoxylate/atropine (Lomotil) to help manage it. Or, they might recommend you take a lower dose of capecitabine (Xeloda). It’s important that you drink plenty of fluids to prevent dehydration. HFS is a condition where the skin on the palms of your hands and soles of your feet can become red, irritated, swollen. This can cause pain and skin peeling. If you develop HFS, your provider might recommend lotions or creams to help manage it, or ask you to pause treatment or take a lower capecitabine (Xeloda) dose.
                    Can I drink alcohol while taking capecitabine (Xeloda)?
                    The manufacturer doesn’t provide specific guidance on what to eat or drink while you’re taking capecitabine (Xeloda). In general, a diet with low alcohol intake is recommended to maintain a healthy diet. Drinking alcohol often can raise the risk of developing some cancers. Doing so can also worsen some of the side effects of capecitabine (Xeloda), including stomach upset and liver irritation. Ask your provider what they recommend when it comes to alcohol while you’re taking capecitabine (Xeloda).
                    Can capecitabine (Xeloda) be crushed?
                    No, don't crush or cut the capecitabine (Xeloda) tablets. The powder from crushed tablets can cause serious side effects if it comes into contact with your skin or eyes. For example, it can cause symptoms such as eye irritation and swelling, skin rash, nausea, and diarrhea. If you need to cut or crush the tablets, talk with your provider. They can help you find a place that professionals trained and equipment needed to do so safely.
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                    What are the risks and warnings for Capecitabine (Xeloda)?

                    Capecitabine (Xeloda) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                    risk-warning

                    Higher bleeding risk when taken with warfarin (Coumadin)

                    • Risk factors: Age 60 years or older

                      Taking capecitabine (Xeloda) with the blood thinner warfarin (Coumadin) can raise your risk of serious and even sometimes life-threatening bleeding. It's thought that capecitabine (Xeloda) can affect how well warfarin (Coumadin) gets broken down in your body, which raises warfarin (Coumadin) levels in your body and your risk of bleeding. If you're taking warfarin (Coumadin), let your warfarin (Coumadin) clinic know about your chemotherapy regimen and when you're taking capecitabine (Xeloda). You'll need to follow up with your clinic more often. That way, they can monitor your warfarin (Coumadin) treatment more closely and adjust your blood thinner dose to lower your risk of serious bleeds.

                      risk-warning

                      Severe diarrhea

                      Capecitabine (Xeloda) can cause diarrhea, which can be serious and lead to dehydration. For milder cases, your provider might recommend anti-diarrheal medications, like loperamide (Imodium A-D). More severe cases have occurred within the first month of taking capecitabine (Xeloda). Make sure to monitor your bowel movements during treatment. Contact your care team or get medical help right away if you have a large increase in stools (4 or more episodes) per day, have diarrhea during the night, or notice blood in your stools along with severe stomach pain and fever. Your provider might ask you to stop taking capecitabine (Xeloda) until your diarrhea gets better.

                      risk-warning

                      Heart damage

                      • Risk factors: History of heart disease

                        Heart problems have occurred in some people taking capecitabine (Xeloda). These problems include heart attack, chest pain, abnormal heart rhythms, and heart failure. Your risk might be higher if you have a history of heart disease. Let your oncologist (cancer specialist) know your medical history so they can monitor you closer if needed.

                        risk-warning

                        Dehydration and kidney problems

                        • Risk factors: History of kidney problems | Taking other medications that can cause kidney problems | Nausea, vomiting, or diarrhea | Anorexia or loss of appetite

                          Capecitabine (Xeloda) can cause dehydration, which can lead to severe kidney failure. Common side effects of this medication include vomiting, diarrhea, and loss of appetite, which can lead to dehydration. Dehydration can also happen when you don't drink enough fluids. Make sure you let your care team know about any side effects that you experience while taking this medication. They can adjust your dose and make sure you're hydrated.

                          risk-warning

                          Serious skin reactions

                          Capecitabine (Xeloda) commonly causes a skin reaction called hand-and-foot syndrome. Most people who experience this do so within months of starting capecitabine (Xeloda). It might start as mild tingling, numbness, or painless swelling or redness in your hands and feet. But if you notice that it becomes painful or have blisters in your hands or feet, and it starts to interfere with your daily activities, let your care team know. Your provider might ask you to pause capecitabine (Xeloda) or take a lower dose until your symptoms resolve.

                          Capecitabine (Xeloda) can also cause rare but serious skin reactions, such as Stevens-Johnson Syndrome and toxic epidermal necrolysis (TEN). Let your provider know right away if you experience fever, rash, blisters after starting treatment.

                          risk-warning

                          Low blood cell counts

                          Risk factors: taking capecitabine (Xeloda) with other chemotherapy medications

                          Though not common, taking capecitabine (Xeloda) can cause your blood cell counts to drop and put you at higher risk for conditions like infections and serious bleed. Your provider will check your blood cell counts before each cycle. If your blood counts are too low, your provider might make adjustments to your dose or pause your treatment until they recover.

                          risk-warning

                          Harm to unborn baby

                          Capecitabine (Xeloda) hasn’t been studied in human pregnancy, but based on animal studies and the way the medication works, it could harm an unborn baby. If you’re a female able to become pregnant, you should use effective birth control while taking capecitabine (Xeloda) and for 6 months after the last dose. If you’re a male who is sexually active with a female who can become pregnant, you should use effective birth control, such as condoms, while taking capecitabine (Xeloda) and for 3 months after the last dose.

                          risk-warning

                          Risk of serious toxicity reaction (in people with a rare genetic condition)

                          Before starting capecitabine (Xeloda), your provider might test you for a rare genetic condition called dihydropyrimidine dehydrogenase (DPD) deficiency. People with this condition might not be able to take capecitabine (Xeloda) or need to take a lower dose because they’re at higher risk for a severe toxicity reaction with symptoms such as mouth sores, diarrhea, and nausea.

                          dosage

                          Capecitabine (Xeloda) dosage forms

                          Typical dosing for Capecitabine (Xeloda)

                          Your provider will calculate your dose based on your body surface area (BSA), which takes into account your height and weight. The dose and duration of therapy also depends on what type of cancer you’re being treated for, and what other anticancer medications or treatments (e.g., radiation) you’re receiving.

                          • The typical dose ranges between 625 mg/m2 - 1250 mg/m2 by mouth twice a day.

                          If you’re receiving radiation, you’ll usually take capecitabine (Xeloda) during radiation treatment, which can last several weeks.

                          If you’re not receiving radiation, capecitabine (Xeloda) is commonly taken for 2 weeks out of every 3-week treatment cycle.

                          interactions

                          Interactions between Capecitabine (Xeloda) and other drugs

                          Capecitabine (Xeloda) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Capecitabine (Xeloda). Please note that only the generic name of each medication is listed below.

                          Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                          • Measles Virus Vaccine, Live
                          • Mumps Virus Vaccine, Live
                          • Rotavirus Vaccine, Live
                          • Rubella Virus Vaccine, Live
                          • Tegafur
                          • Varicella Virus Vaccine, Live
                          • Zoster Vaccine, Live

                          Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

                          Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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                          contraindications-icon

                          Capecitabine (Xeloda) contraindications

                          Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Capecitabine (Xeloda) will not be safe for you to take.

                          • Hypersensitivity to fluorouracil

                          alternatives

                          What are alternatives to Capecitabine (Xeloda)?

                          There are a number of medications that your doctor can prescribe in place of Capecitabine (Xeloda). Compare a few possible alternatives below.
                          Capecitabine (Xeloda)
                          Used for:
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                          Gemcitabine
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                          Capecitabine (Xeloda) images

                          Peach Oblong 191 And 77 - Capecitabine 500mg Tablet
                          This medicine is Peach, Oblong Tablet Imprinted With "191" And "77".Peach Oblong 191 And 77 - Capecitabine 500mg Tablet
                          Peach Oval H And 3 - Capecitabine 500mg Tablet
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                          Peach Oval H And 3 - Capecitabine 500mg Tablet
                          This medicine is Peach, Oval Tablet Imprinted With "H" And "3".Peach Oval H And 3 - Capecitabine 500mg Tablet
                          Pink Oblong Cap And 500 - Capecitabine 500mg Tablet
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                          Peach Oval 500 And A016 - Capecitabine 500mg Tablet
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                          Peach Oblong C500 - Capecitabine 500mg Tablet
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                          Peach Oblong 500 And C - Capecitabine 500mg Tablet
                          This medicine is Peach, Oblong Tablet Imprinted With "C" And "500".Peach Oblong 500 And C - Capecitabine 500mg Tablet

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                          References

                          Best studies we found

                          Braghiroli, C. S., et al. (2017). Do you know this syndrome? Hand-foot syndrome. Anais Brasileiros de Dermatologia.

                          Genentech, Inc. (2023). Xeloda- capecitabine tablet, film coated [package insert]. DailyMed.

                          Kwakman, J. J. M., et al. (2020). Management of cytotoxic chemotherapy-induced hand-foot syndrome. Oncology Reviews.

                          View All References (14)

                          Ly, R. C., et al. (2020). Severe capecitabine toxicity associated with a rare DPYD variant identified through whole-genome sequencing. Journal of Clinical Oncology Precision Oncology.

                          MedlinePlus. (2015). Dihydropyrimidine dehydrogenase deficiency.

                          National Cancer Institute. (2019). Radiation therapy to treat cancer.

                          National Cancer Institute. (2022). Eating hints: Before, during, and after cancer treatment.

                          National Cancer Institute. (2023). Capecitabine.

                          National Cancer Institute. (2024). Pancreatic cancer treatment (PDQ®)–Patient version.

                          National Comprehensive Cancer Network. (2023). Pancreatic cancer.

                          National Comprehensive Cancer Network. (2023). Stomach cancer.

                          National Comprehensive Cancer Network. (2024). Colon cancer.

                          National Comprehensive Cancer Network. (2024). Esophageal cancer.

                          National Comprehensive Cancer Network. (2024). Metastatic breast cancer.

                          National Comprehensive Cancer Network. (2024). Rectal cancer.

                          Reigner, B., et al. (2001). Clinical pharmacokinetics of capecitabine. Clinical Pharmacokinetics.

                          West, H. J., et al. (2017). Chemotherapy-induced hair loss (alopecia). Journal of the American Medical Association Oncology.

                          GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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