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Busulfan Coupon - Busulfan 10ml of 6mg/ml vial

busulfan

Generic Busulfex
Used for Leukemia
Used for Leukemia

Busulfan (Busulfex) is an anticancer treatment option that’s given before you receive a stem cell transplant for chronic myelogenous leukemia (CML). It’s typically used in combination with other anticancer medications. Busulfan (Busulfex) is given as an infusion through the vein by a healthcare provider. You have to stay in the hospital to receive your doses as well as during the transplant recovery process so your provider can monitor you.

Reviewed by:
reviewer
Jenny Zhang, PharmD, BCOP
reviewer
Cydnee Ng, PharmD
Last reviewed on August 9, 2022
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageInteractionsAlternativesImagesPricesMedicare
basics-icon

What is Busulfan (Busulfex)?

What is Busulfan (Busulfex) used for?

  • Chemotherapy given before a stem cell transplant (conditioning regimen) for people with chronic myelogenous leukemia (CML)

How Busulfan (Busulfex) works

Busulfan (Busulfex) is a type of anticancer medication called an alkylating agent. It works by damaging the cancer cells’ genetic material, leading to cell death.

Are you looking for information on Myleran (busulfan) tablets instead?

Drug Facts

Common BrandsBusulfex
Drug ClassAnticancer agent
Controlled Substance ClassificationNot a controlled medication
Generic StatusLower-cost generic available
AvailabilityPrescription only
basics-icon

What are the side effects of Busulfan (Busulfex)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Nausea (98%)
  • Mouth sores or inflammation (97%)
  • Vomiting (95%)
  • Weight loss or lack of appetite (85%)
  • Diarrhea (84%)
  • Difficulty sleeping (84%)
  • Fever (80%)
  • Stomach pain (72%)
  • Anxiety (72%)
  • Headache (69%)

Other Side Effects

  • Weakness
  • Dizziness
  • Chills
  • General pain
  • Indigestion or acid reflux
  • Constipation
  • Stuffy nose
  • Rash
  • High blood sugars

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Serious infections: repeated fevers, chills, cough, trouble breathing, severe diarrhea, vomiting, painful or frequent urination
  • Serious bleeds: bleeding or bruising that doesn’t stop or go away, large amount of bleeding, blood in the urine, throwing up blood, bloody or black and tarry stool
  • Severe liver problems: yellowing of the skin or eyes (jaundice), dark urine, right upper stomach pain, nausea, vomiting, tiredness, loss of appetite
  • Heart problems: chest pain, shortness of breath, rapid heartbeat, swelling of the legs or feet
  • Seizures

Source: DailyMed

The following side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Black, tarry stools

bloated abdomen or stomach

blood in the urine or stools

blurred vision

chest pain

cough or hoarseness

dizziness

fast or irregular breathing

fast, pounding, or irregular heartbeat or pulse

fever or chills

headache

lower back or side pain

nervousness

pain and fullness in the upper abdominal or stomach

painful or difficult urination

pinpoint red spots on the skin

pounding in the ears

skin rash or itching

slow heartbeat

swelling of the eyes or eyelids

tightness in the chest

trouble breathing

unusual bleeding or bruising

weight gain

yellow eyes and skin

Incidence not known

seizures

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Acid or sour stomach

back pain

belching

bloody nose

depression

diarrhea

difficulty having a bowel movement (stool)

fear

heartburn

indigestion

loss of appetite

lack or loss of strength

sneezing

stomach discomfort or upset

stuffy nose or runny nose

swelling or inflammation of the mouth

tenderness, pain, swelling, warmth, skin discoloration, and prominent superficial veins over affected area

trouble sleeping

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

pros-and-cons

Pros and cons of Busulfan (Busulfex)

thumbs-up

Pros

Is a component of the only curative treatment for CML (if eligible for transplant)

Might be considered in children before a stem cell transplant for certain cancers

thumbs-down

Cons

Requires hospital admission

Can raise your risk for infections, bleeding, or bruising

Each infusion takes 2 hours.

pharmacist-tips

Pharmacist tips for Busulfan (Busulfex)

pharmacist

  • Since high doses of busulfan (Busulfex) can cause seizures, you’ll be given an antiseizure medication to prevent this risk. You’ll typically start the antiseizure medication 12 hours before your first busulfan (Busulfex) injection, and then continue until 24 hours after your last dose of busulfan (Busulfex).

    • Some common medications, such as acetaminophen (Tylenol) and metronidazole (Flagyl), can interact with busulfan (Busulfex). They can affect how well busulfan (Busulfex) is removed from your body. These medications can cause the level of busulfan (Busulfex) in your body to be too high and raise your risk for serious side effects. It's important to tell your provider and pharmacist about all the medications you’re taking to avoid any serious interactions. Before starting or stopping any medications, let your provider know, so they can make the appropriate dose adjustments, if needed.

      • If you’re a woman who can get pregnant, you should use birth control while receiving busulfan (Busulfex) and for 6 months after your last dose. This medication can cause harm to an unborn baby.

        • If you’re a man with a female partner who can get pregnant, you should use birth control measures, such as condoms, while you’re receiving busulfan (Busulfex) and for 3 months after your last dose. It’s possible for busulfan (Busulfex) to cause harm to the unborn baby of your female partner if you’re taking this medication.

          faqs

          Frequently asked questions about Busulfan (Busulfex)

          Why do I need to receive high-dose chemotherapy like busulfan (Busulfex) before a stem cell (bone marrow) transplant?
          Chemotherapy is used to prepare your body for a stem cell transplant. It might also be given along with radiation, depending on your treatment regimen and what type of cancer you have. Before you receive a transplant of new healthy cells, you’re given high-dose chemotherapy so it can help with a few things. It destroys any remaining cancer cells left in your body and makes room in your bone marrow for the new cells. It also helps lower your immune system to prevent your body from rejecting the new cells.
          How can I lower my chances of developing an infection while receiving busulfan (Busulfex)?
          Busulfan (Busulfex) will lower your blood cell counts, weaken your immune system, and make you more likely to develop an infection. This can be a serious problem, because it’s also harder to fight off infections with a weakened immune system. There are many ways you can lower your chances of developing an infection. Wash your hands often, and avoid crowded places and people who are sick. To avoid food-borne illnesses, it’s recommended to wash raw fruits and vegetables before eating, and cook foods thoroughly.
          Is busulfan (Busulfex) safe if I have liver problems?
          Let your provider know if you have problems with your liver, because you might be at higher risk of side effects from busulfan (Busulfex). They can monitor you more closely during treatment. With liver problems, your body might have a harder time getting rid of the medication. This can cause higher levels of busulfan (Busulfex) in your body and raise your risk for more side effects. It’s important to note that going through a stem cell transplant and receiving high doses of busulfan (Busulfex) can raise your risk for liver problems too.
          Is busulfan (Busulfex) safe in pregnancy?
          Busulfan (Busulfex) isn’t recommended during pregnancy. Based on animal studies, it can cause harm to your unborn baby and shouldn’t be used in pregnancy. Let your provider know right away if you become pregnant during busulfan (Busulfex) treatment, or if you have any questions about pregnancy while receiving the medication.
          Is busulfan (Busulfex) safe while breastfeeding?
          Busulfan (Busulfex) isn’t recommended while breastfeeding. We don’t know if it can pass into breast milk, but if it does, it can cause serious harm to nursing babies. Talk to your provider if you have any questions about other ways to feed your baby while receiving busulfan (Busulfex).
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          What are the risks and warnings for Busulfan (Busulfex)?

          Busulfan (Busulfex) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

          risk-warning

          Low blood cell counts

          Busulfan (Busulfex) can cause your red blood cell, white blood cell, and platelet counts to drop, especially with the high doses of this medication required before a stem cell transplant. When the number of these cells are lower than normal, you’re at risk of developing anemia, infections, and bleeding or bruising. In some cases, your blood cell counts may be low for a while. This is because your chemotherapy medications can weaken your bone marrow and affect its ability to make new blood cells like normal.

          To prevent serious problems, it’s absolutely necessary to receive a stem cell transplant after receiving high doses of busulfan (Busulfex). Your provider will closely monitor your blood counts through routine lab work after you receive this medication. They will continue to check your blood counts until they return to normal after your transplant. Let your provider know as soon as possible if you experience extreme tiredness, rapid breathing, fevers, chills, or bleeding and bruising that doesn’t stop or go away.

          risk-warning

          Seizures

          At doses used to prepare for a stem cell transplant, busulfan (Busulfex) can cause seizures. Before starting treatment, you’ll be given an antiseizure medication to lower your risk of developing a seizure. Make sure to tell your provider if you have a history of seizures, head injury, or take medications that can make you more likely to have a seizure. They can monitor you more closely.

          risk-warning

          Liver injury or damage

          • Risk factors: Higher levels of busulfan (Busulfex) in your body | Previous radiation treatment | Have received three or more cycles of chemotherapy | Previous stem cell transplant

            There’s a small chance that busulfan (Busulfex) can cause liver injury. This can lead to serious problems where blood flow is blocked in your liver (hepatic veno-occlusive disease). Your provider will monitor your liver labs regularly after receiving busulfan (Busulfex) and for about a month after transplant. Let your provider know right away if you experience right-side stomach pain, yellowing of the eyes or skin, dark urine, tiredness, nausea or vomiting, or loss of appetite, as these can be signs of liver problems.

            risk-warning

            Harm to unborn baby

            Based on animal studies, busulfan (Busulfex) can harm an unborn baby. Because of this risk, regardless of your sex, you should use birth control during treatment with busulfan (Busulfex) to prevent pregnancy. After treatment, continue to use birth control for another 3 months (for males) or 6 months (for females). Let your provider know right away if you or your partner becomes pregnant during this time.

            risk-warning

            Heart problems

            It’s not known if there’s a risk of heart problems in people receiving the busulfan (Busulfex) injection before a stem cell transplant for CML. But rare cases of fluid or blood buildup around the heart were reported in children with thalassemia (a genetic blood condition) who took oral busulfan before undergoing transplantation. Most of the time, children experienced stomach pain and vomiting before the heart problems started. Tell your provider immediately if you have chest pain, shortness of breath, swelling of your legs or feet, dizziness, or a rapid heartbeat.

            risk-warning

            Lung problems

            Although rare, long-term busulfan (Busulfex) use can cause lung damage and scarring (pulmonary fibrosis). This can take several months to years to develop after receiving busulfan (Busulfex) for a long time. Notify your provider right away if you start experiencing a cough or difficulty breathing.

            dosage

            Busulfan (Busulfex) dosage forms

            Typical dosing for Busulfan (Busulfex)

            This medication is an injection into a vein (intravenous, IV) that’s given by a healthcare provider. Your provider will calculate your dose of busulfan (Busulfex) based on your body weight.

            One possible dosing regimen is 0.8 mg/kg given every 6 hours for 4 consecutive days before a stem cell transplant. This is a total of 16 doses. Your course of busulfan (Busulfex) will begin 7 days before your transplant (on days -7, -6, -5, and -4, with day 0 as the day you’ll receive a transplant). With this conditioning regimen, busulfan (Busulfex) is given along with another anticancer medication called cyclophosphamide.

            interactions

            Interactions between Busulfan (Busulfex) and other drugs

            Busulfan (Busulfex) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Busulfan (Busulfex). Please note that only the generic name of each medication is listed below.

            Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

            Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

            Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

            alternatives

            What are alternatives to Busulfan (Busulfex)?

            There are a number of medications that your doctor can prescribe in place of Busulfan (Busulfex). Compare a few possible alternatives below.
            Busulfan (Busulfex)
            Used for:

            • Chemotherapy given before a stem cell transplant (conditioning regimen) for people with chronic myelogenous leukemia (CML)

            View Prices
            Cyclophosphamide
            Used for:
            $153.01 Lowest GoodRx priceView Prices
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            Busulfan (Busulfex) images

            colorless - Busulfan 60mg / 10mL Solution for Injection
            This medicine is Colorless Vial.colorless - Busulfan 60mg / 10mL Solution for Injection

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