How Much Is Breztri Aerosphere Without Insurance?

Chronic obstructive pulmonary disease (COPD) is an umbrella term for lung conditions, including chronic bronchitis and emphysema, that can make breathing difficult. Not only does COPD cause coughing, wheezing, shortness of breath, and other symptoms, but it can also bring about fatigue and make daily activities difficult. 

For some people, Breztri Aerosphere (budesonide / glycopyrrolate / formoterol) can provide relief. This “triple therapy” inhaler contains:

• The inhaled corticosteroid budesonide to reduce airway inflammation

• The long-acting muscarinic antagonist glycopyrrolate to relax airways

• The long-acting beta agonist formoterol that also helps with better airflow

Breztri Aerosphere can be prescribed for long-term treatment. People typically inhale 4 puffs of the medication daily: 2 in the morning and 2 in the evening. A single inhaler contains 120 metered-dose inhalations, which is a 30-day supply. While Breztri Aerosphere may make breathing easier and reduce COPD flare-ups, it shouldn't be used for sudden breathing emergencies, such as a COPD exacerbation.

You can save on Breztri whether you have insurance or not. Keep reading to find out how you can access this COPD medication at the most affordable price.

How much does Breztri Aerosphere cost?

The list price for 1 Breztri Aerosphere inhaler (a 30-day supply) is about $665, as of February 2025. But that isn’t necessarily how much you’ll pay.

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Without insurance, 1 Breztri inhaler — which provides 120 inhalations of budesonide 160 mcg / glycopyrrolate 9 mcg / formoterol 4.8 mcg — costs $796.36 on average. But with a GoodRx coupon, you may pay as little as $674.44. There is no generic alternative available.

What factors affect the cost of Breztri Aerosphere?

Without insurance, what you’ll pay for Breztri Aerosphere depends on several factors, including your:

• Pharmacy: Pharmacies set their own prices, so where you fill your prescription is important.

• Location: Prescription medication costs can vary by geographic location, as well.

• Fill quantity: Medications can be more affordable over time when purchased beyond a monthly supply. 

Does insurance cover Breztri Aerosphere?

Most health insurance plans cover Breztri Aerosphere. If you have insurance, review your plan’s summary of benefits and coverage and formulary (list of covered medications) to determine whether Breztri Aerosphere is covered. If not, contact your plan and ask about your coverage options. You can also discuss alternatives with your prescriber or pharmacist.

How different insurance plans cover Breztri Aerosphere

Almost every Medicaid plan requires enrollees to get prior authorization before covering Breztri Aerosphere. To get prior authorization, your prescriber will have to provide documentation that demonstrates Breztri Aerosphere is medically necessary for you. 

Step therapy (trying other, usually more affordable, medications first) is most commonly required for people covered by Medicaid. People with Affordable Care Act (ACA) marketplace plans and commercial (private) plans not purchased through the ACA marketplace are rarely required to do step therapy.

EXPERT PICKS: WHAT TO READ NEXT

• Learn more about COPD inhalers. Chronic obstructive pulmonary disease (COPD) is often treated with inhalers that open airways and reduce inflammation.

• Biologics can enhance your COPD treatment. Dupixent and Nucala are add-on injectable biologic medications that can help manage COPD symptoms alongside your inhaler.

• Combination inhalers and side effects: Side effects of using a combination inhaler, which can treat COPD and other lung conditions, may include oral thrush, dry mouth, and sore throat.

The chart below shows how frequently different types of insurance cover Breztri Aerosphere, and whether prior authorization or step therapy is usually required.

Source: Managed Markets Insight & Technology, LLC™, as of September 11, 2025. (See methodology below.)

Tips if your medication isn’t covered by insurance

If your insurance doesn’t cover Breztri Aerosphere, try these options:

• Use a GoodRx coupon to potentially save on your prescription.

• Ask your prescriber about less costly treatments that meet your needs. This could mean switching to another brand-name medication that costs less or a medication that has a generic option available. (Breztri Aerosphere has no generic alternative.)

• Request a formulary exception from your insurance company. If your request is denied, you have the right to file an appeal with your plan.

• When it’s time for open enrollment, compare health insurance plans to find one that covers your medications.

Ways to save on Breztri Aerosphere

Whether or not you have insurance, there are ways to reduce the cost of Breztri Aerosphere. Here are five options.

1. Use a GoodRx coupon

You may be able to use a free GoodRx coupon to lower the price of your Breztri Aerosphere prescription. For example, without insurance, you could pay as low as $674.44 for 1 inhaler with a GoodRx coupon at certain pharmacies. 

Visit www.goodrx.com or download the GoodRx app on your mobile device to use a coupon. Here’s how:

• On the app or website, type “Breztri Aerosphere” in the search field.

• Choose the desired quantity. Input your ZIP code or address, or select “Use my current location,” so you see results for local pharmacies.

• Choose how you want to receive your coupon. You may want it emailed or texted to you, or you may want to print it out.

• Take your coupon with you to the pharmacy. Present the coupon to the pharmacy’s staff early in the filling process to help avoid delays at the pickup counter.

2. See if you qualify for a copay savings card

If you have commercial insurance, you may qualify for Breztri Zero Pay, a copay savings program offered by the manufacturer, AstraZeneca. If you qualify, AstraZeneca will take care of up to 100% of your costs. There are no income requirements, and you can apply for the copay savings card online, via text, or by phone. 

You are not eligible for the copay savings card if you are enrolled in:

• Any government-funded health insurance program, such as Medicare, Medicaid, or Tricare

• An employer-sponsored group waiver health plan

• A government-subsidized prescription medication benefit program for retirees

• A prescription insurance program funded by a state or the federal government

3. Check if you’re eligible for a patient assistance program

If you don't have insurance, or have Medicare and cannot afford Breztri, you may be eligible for the manufacturer's patient assistance program: AZ&Me Prescription Savings Program. 

Use this tool to perform an online eligibility assessment. You can also go directly to the application site. You must meet the following requirements to qualify for assistance through AZ&Me:

• Be a U.S. resident

• Be treated by a U.S.-based healthcare professional

• Not have a commercial insurance plan or government-sponsored insurance other than Medicare

• Not receive any other financial assistance for medication

• Have an adjusted gross income below the required limit

You may also be able to get help through other patient assistance programs. For instance, the Patient Access Network (PAN) Foundation offers grants to pay treatment costs for people who have a demonstrated need for financial support, are covered by government-funded insurance, and meet income requirements. The PAN Foundation has a COPD fund that can help cover copays and other costs for Breztri Aerosphere. At publication time, this fund was not accepting new enrollees, but you can join the wait list.

4. Ask about a 90-day supply

You may be able to reduce your overall costs by getting a 90-day fill of Breztri (3 inhalers) rather than a 30-day supply (1 inhaler).

5. Tap into your HSA, FSA, or HRA

Consider using a flexible spending account (FSA), a health savings account (HSA), or a health reimbursement arrangement (HRA) to pay for your medication. You can enjoy multiple tax benefits, and reduce your out-of-pocket costs, by using an FSA, HSA, or HRA to pay for qualified healthcare expenses like Breztri. But be sure to review your account’s contribution limits, rollover limits, and eligible expenses.

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Written by:

Tamara E. Holmes

Tamara E. Holmes is a Washington, DC-based freelance journalist and content strategist who has been writing about personal finance, health, and health insurance for more than a decade. Her work has appeared in various print and online publications, such as USA Today, AARP, Working Mother, and Diversity Woman.

Edited by:

Cindy George, MPH

Cindy George, MPH, is the senior personal finance editor at GoodRx. She is an endlessly curious health journalist and digital storyteller.

Reviewed by:

Joshua Murdock, PharmD, BCBBS

Joshua Murdock, PharmD, BCBBS, is a licensed pharmacist in Arizona, Colorado, and Rhode Island. He has worked in the pharmacy industry for more than 10 years and currently serves as a pharmacy editor for GoodRx.

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Methodology

We obtained national prescription coverage data for each medication from Managed Markets Insight & Technology (MMIT). The data reflects health insurance coverage as of September 11, 2025. 

We calculated the percentage of enrollees in plans that cover each medication by dividing the number of enrollees covered for the medication within a specific insurance channel (e.g., ACA, Medicare, Medicaid) by the total number of enrollees in all plans within that channel. 

We determined the percentage of enrollees in plans with a prior authorization requirement by calculating the proportion of enrollees in plans that required prior authorization for the medication within each channel.

Finally, we measured the percentage of enrollees in plans with a step therapy requirement by calculating the proportion of enrollees in plans that imposed step therapy requirements for the medication in each channel. 

These estimates, derived from national MMIT coverage data, provide insight into health insurance coverage for each medication. They take into account restrictions such as prior authorization, step therapy, and quantity limits. The percentages are expressed relative to the total number of enrollees covered by various insurance channels, including ACA plans, commercial (excluding ACA) plans, Medicare, and Medicaid (both state-run and managed care plans).