Typical dosage for Arsenic Trioxide
The recommended dose depends on the treatment phase (induction or consolidation).
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Refractory or relapsed APL
- Induction: The typical dose is 0.15 mg/kg of bodyweight, injected into a vein once a day until bone marrow remission or for up to 60 days.
- Consolidation: The typical dose is 0.15 mg/kg of bodyweight, injected into a vein once a day for 25 doses over 5 weeks Consolidation begins 3-6 weeks after completing induction
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Newly diagnosed, low-risk APL
- Induction: The typical dose is 0.15 mg/kg of bodyweight, injected into a vein once a day with tretinoin (ATRA) until bone marrow remission or for up to 60 days.
- Consolidation: The typical dose is 0.15 mg/kg of bodyweight, injected into a vein once a day with tretinoin (ATRA) for 5 days during weeks 1-4. After that, there is a 4-week break with no medication.
- This dosing schedule is repeated for a total of 4 cycles.
- You won’t receive any tretinoin (ATRA) during weeks 5-6 of the last cycle.
