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Rosuvastatin (Crestor) is a statin. The main way it works is by blocking the enzyme (protein) in your liver that makes cholesterol. As a result, rosuvastatin (Crestor) lowers your "bad" cholesterol (called low-density lipoprotein, or LDL). Rosuvastatin (Crestor) can also raise your "good" cholesterol (called high-density lipoprotein, or HDL) and lower your triglyceride levels.