Andexxa

Q: What is Andexxa (andexanet alfa)?

Andexxa (andexanet alfa) is a manmade form of coagulation factor Xa, a protein naturally found in your blood that's important for blood clotting. It attaches to blood thinners called [Xarelto (rivaroxaban)](https://www.goodrx.com/xarelto/what-is) and [Eliquis (apixaban)](https://www.goodrx.com/eliquis/what-is) to stop them from working in your body. Andexxa (andexanet alfa) also helps raise levels of thrombin, an enzyme involved with blood clotting.

Q: Can I get a prescription for Andexxa (andexanet alfa) to have at home in case of a serious bleed?

No. Andexxa (andexanet alfa) is only available as an injection that's given through your vein by a trained healthcare provider. You can't get a prescription to have it at home in case of a bleeding event while you're taking Xarelto (rivaroxaban) or Eliquis (apixaban). If you get a serious or uncontrollable bleed while taking blood thinners, get medical help right away so you can be treated.

Q: Are there any serious risks of taking Andexxa (andexanet alfa)?

Since Andexxa (andexanet alfa) stops certain blood thinners from working, treatment with this medication has been linked to blood clots, poor blood flow to parts of the body, heart attack, stroke, and cardiac arrest (when the heart stops beating suddenly). These life-threatening side effects typically happen around a few days to a week after receiving Andexxa (andexanet alfa), but could appear later. Your provider will monitor you for blood clots and restart your blood-thinning medications as soon as possible to prevent them from happening.

Q: Can Andexxa (andexanet alfa) be used to treat bleeding from other blood thinners?

No, Andexxa (andexanet alfa) has only been shown to work for bleeding caused by Xarelto (rivaroxaban) and Eliquis (apixaban). If you're taking a different blood thinner, speak to your provider about what treatment options are available in the event of serious bleeding.

andexanet alfa

Used for Anticoagulant Reversal, Hemorrhage

Andexxa (andexanet alfa) is an injectable medication used to treat life-threatening or uncontrolled bleeding in people taking anticoagulants (blood thinners) called Xarelto (rivaroxaban) or Eliquis (apixaban). It's typically given in the hospital or urgent care setting by a trained healthcare provider through your vein.

Reviewed by:

Kristianne Hannemann, PharmD

Allison Gourley, PharmD

Last reviewed on April 10, 2022

What is Andexxa (andexanet alfa)?

Drug facts

Common Brands	Andexxa
Drug Class	Antidote
Controlled Substance Classification	Not a controlled medication
Generic Status	No lower-cost generic available
Availability	Prescription only

Common Brands

Andexxa

Drug Class

Antidote

Controlled Substance Classification

Not a controlled medication

Generic Status

No lower-cost generic available

Availability

Prescription only

Common questions about Andexxa

Andexxa is a manmade form of coagulation factor Xa, a protein naturally found in your blood that's important for blood clotting. It attaches to blood thinners called Xarelto (rivaroxaban) and Eliquis (apixaban) to stop them from working in your body. Andexxa also helps raise levels of thrombin, an enzyme involved with blood clotting.

No. Andexxa is only available as an injection that's given through your vein by a trained healthcare provider. You can't get a prescription to have it at home in case of a bleeding event while you're taking Xarelto (rivaroxaban) or Eliquis (apixaban). If you get a serious or uncontrollable bleed while taking blood thinners, get medical help right away so you can be treated.

The most common side effects reported by people who were given Andexxa were urinary tract infections (UTIs), pneumonia, and infusion-related reactions. Symptoms of infusion-related reactions included flushing, feeling hot, cough, change in taste, and shortness of breath. Most people (90%) didn't require any treatment for their reaction.

Since Andexxa stops certain blood thinners from working, treatment with this medication has been linked to blood clots, poor blood flow to parts of the body, heart attack, stroke, and cardiac arrest (when the heart stops beating suddenly). These life-threatening side effects typically happen around a few days to a week after receiving Andexxa, but could appear later. Your provider will monitor you for blood clots and restart your blood-thinning medications as soon as possible to prevent them from happening.

No, Andexxa has only been shown to work for bleeding caused by Xarelto (rivaroxaban) and Eliquis (apixaban). If you're taking a different blood thinner, speak to your provider about what treatment options are available in the event of serious bleeding.

Andexxa

What is Andexxa (andexanet alfa)?

Drug facts

Common questions about Andexxa

Andexxa (andexanet alfa) dosage

Typical dosage for Andexxa (andexanet alfa)

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Common questions about Andexxa

What is Andexxa (andexanet alfa)?

Drug facts

Common questions about Andexxa

What is Andexxa?

Can I get a prescription for Andexxa to have at home in case of a serious bleed?

What are the side effects of Andexxa?

Are there any serious risks of taking Andexxa?

Can Andexxa be used to treat bleeding from other blood thinners?

Andexxa (andexanet alfa) dosage

Typical dosage for Andexxa (andexanet alfa)

Common questions about Andexxa

What is Andexxa?

Can I get a prescription for Andexxa to have at home in case of a serious bleed?

What are the side effects of Andexxa?

Are there any serious risks of taking Andexxa?

Can Andexxa be used to treat bleeding from other blood thinners?