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Ajovy Coupon - Ajovy 225mg/1.5ml autoinjector

Ajovy

fremanezumab
Used for Migraine
Used for Migraine

Ajovy (fremanezumab or fremanezumab-vfrm) is an injection under the skin that helps prevent migraines in adults. This medication is convenient because it only needs to be used once every month or once every 3 months. The only observed side effects in clinical studies were injection-site reactions (e.g., pain, swelling, redness). Ajovy (fremanezumab) is available as a prefilled autoinjector pen and a prefilled syringe. It's currently only available as a brand-name medication; there's no generic yet.

Last reviewed on August 8, 2023
basics-icon

What is Ajovy (fremanezumab)?

What is Ajovy (fremanezumab) used for?

  • Prevention of migraines in adults

How Ajovy (fremanezumab) works

Ajovy (fremanezumab) is a calcitonin gene-related peptide (CGRP) receptor blocker. It's a monoclonal antibody that blocks a protein called calcitonin gene-related peptide (CGRP) in the brain and nervous system. CGRP is thought to be involved with migraines and causing pain. By blocking CGRP, Ajovy (fremanezumab) helps block migraines from happening.

Drug Facts

Common BrandsAjovy
Drug ClassCGRP receptor blocker
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only

More on Ajovy (fremanezumab) essentials

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Avg retail price
$915.62(save 19.95%)
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$732.95
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What are the side effects of Ajovy (fremanezumab)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Pain, swelling, or redness at the injection site (43-45%)

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Allergic reactions: hives, itching, swelling of face or tongue, difficulty breathing

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

  • Allergic reactions or angioedema—skin rash, itching or hives, swelling of the face, eyes, lips, tongue, arms, or legs, trouble swallowing or breathing
  • Increase in blood pressure
  • Raynaud syndrome—cool, numb, or painful fingers or toes that may change color from pale, to blue, to red

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

  • Pain, redness, or irritation at injection site
pros-and-cons

Pros and cons of Ajovy (fremanezumab)

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Pros

Taken only once per month or once every 3 months

Can store at room temperature for up to 7 days, if needed

Available as a prefilled syringe and a prefilled autoinjector

Manufacturer offers a savings program for certain people

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Cons

Might be difficult for some people to use properly

Only used for preventing migraines (not for treating a migraine attack)

Available as a brand-name medication only

Hasn't been studied in children younger than 18 years old

pharmacist-tips

Pharmacist tips for Ajovy (fremanezumab)

pharmacist
  • You should receive training from your provider or pharmacist on how to use Ajovy (fremanezumab). Make sure you know how to give yourself the medication to avoid accidentally hurting yourself or wasting the medication. Read the instructions for use for the autoinjector or the prefilled syringe. Contact your pharmacist or provider if you have any questions.

    • Ajovy (fremanezumab) comes as a prefilled syringe or a prefilled autoinjector that contains 225 mg of medication. It's given either once per month or once every 3 months. If your prescribed dose is 675 mg every 3 months, then you'll have to give yourself three 225 mg injections in a row to get your full dose. Make sure you choose a different area of skin for each injection to help prevent bruising or irritation on your skin.

      • Keep Ajovy (fremanezumab) in the carton it comes in to protect it from light. Store it in the refrigerator; don't freeze it. When you're ready for your dose, take the medication out of the refrigerator and lay it on a flat surface to warm up for at least 30 minutes. Don't try to shake or warm up the medication any other way.

        • Inject Ajovy (fremanezumab) under the skin into the fatty tissue of the front of your thighs (at least 2 inches above your knee and 2 inches below your groin) or stomach area (at least 2 inches away from the belly button). You can also inject the medication into the fleshy area at the back of your upper arms with someone else's help. Never inject the medication into your muscle or vein.

          • Always check the medication solution to make sure it's either clear and colorless or slightly yellow before using it. If it's cloudy, discolored, has particles (chunks), or frozen, don't use it. Additionally, don't use Ajovy (fremanezumab) if any part of the syringe or autoinjector is broken or has any visible damage to it (e.g., cracks, leaks). Use a new syringe or autoinjector.

            • Each Ajovy (fremanezumab) syringe and autoinjector provides a single dose of medication. Throw away the syringe and autoinjector after each use by placing them in a sharps container or something made of heavy-duty plastic (e.g., empty milk carton, laundry detergent bottle). This lowers the risk of needlestick injuries. Don't throw them away in your trash can. Learn more about how to throw away your sharps on the FDA's website.

              • If you forget to take your dose at the time you normally take it, inject the medication as soon as you remember. Then, continue to take Ajovy (fremanezumab) each month (or every 3 months) from the date of your last dose.

                • If you're traveling and don't have access to a refrigerator, you can keep Ajovy (fremanezumab) at room temperature for up to 7 days. Don't put Ajovy (fremanezumab) back in the fridge after it has reached room temperature.

                  More on Ajovy (fremanezumab) tips

                  faqs

                  Frequently asked questions about Ajovy (fremanezumab)

                  How long does Ajovy (fremanezumab) stay in your system?
                  It takes about 5 months for most of Ajovy (fremanezumab) to leave your body after a single dose. If you're having side effects from Ajovy (fremanezumab), they might last up until the time it takes for the medication to clear out of your system. Keep in mind that this time frame is an estimate based on the half-life of Ajovy (fremanezumab), which is a measure of how long it takes for half of the medication to clear from your system.
                  How long can Ajovy (fremanezumab) be out of the fridge?
                  Ajovy (fremanezumab) can be stored out of the fridge and at room temperature for up to 7 days. Once stored at room temperature, don't put it back in the refrigerator.
                  How long does it take for Ajovy (fremanezumab) to work?
                  For some people, Ajovy (fremanezumab) can start to work as early as 1 week after the first dose. Keep in mind that it might take a little longer (up to 1 month of treatment) for others to see improvement. Follow up with your provider regularly to discuss how well the medication is working for you.
                  Does Ajovy (fremanezumab) cause weight gain?
                  No, weight gain wasn't a reported side effect from people taking Ajovy (fremanezumab) in clinical studies. If you experience unexpected weight changes while you're taking Ajovy (fremanezumab), speak with your provider to discuss possible causes.
                  Can I take Ajovy (fremanezumab) a few days early?
                  It's best to take Ajovy (fremanezumab) as scheduled. Taking Ajovy (fremanezumab) early routinely can raise your risk for side effects. If needed, ask your provider whether it's possible to take a dose early as a one-time occurrence.
                  Where is Ajovy (fremanezumab) injected?
                  Ajovy (fremanezumab) can be injected into the front of your thighs (at least 2 inches above your knee and 2 inches below your groin) or stomach area (at least 2 inches away from the belly button). You can also inject the medication into the fleshy area at the back of your upper arm, but you'll need someone to help you. Make sure to use a different site for each injection to lower the risk of bruising and irritation to your skin. Don't inject into skin that's tender, red, bruised, calloused (hard), or tattooed or into areas with scars or stretch marks. This helps avoid pain or damage to your skin.
                  How well does Ajovy (fremanezumab) work?
                  In studies, people with chronic migraines (having 15 or more headache days per month) had an average of 5 fewer migraine days per month after taking Ajovy (fremanezumab) for 3 months. Participants with episodic migraines (having fewer than 15 migraine days per month) had an average of 3.5 fewer migraine days per month after taking Ajovy (fremanezumab) for 3 months.
                  Can you take Ajovy (fremanezumab) while pregnant?
                  So far, there's not enough information about how Ajovy (fremanezumab) affects pregnant women and their unborn baby, so it's not known whether it's safe to use during pregnancy. But animal studies showed that Ajovy (fremanezumab) didn't cause any harm to unborn babies. Keep in mind that what happens in animals isn't always representative of what happens in humans. If you're pregnant or thinking of getting pregnant, talk to your provider to see whether Ajovy (fremanezumab) is right for you. If you become pregnant while you're taking Ajovy (fremanezumab), it's encouraged that you enroll in the manufacturer's Migraine Pregnancy Registry. This program helps researchers learn more about the risks and health outcomes of using the medication during pregnancy. Enroll in the registry by calling 1-833-927-2605 or by visiting their website.
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                  What are the risks and warnings for Ajovy (fremanezumab)?

                  Ajovy (fremanezumab) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

                  risk-warning

                  Allergic reactions

                  Allergic reactions to Ajovy (fremanezumab) are possible. These reactions can include hives, rash, and itching. They're typically mild, but can sometimes be severe. Some people also experienced facial swelling and anaphylaxis (closing of the throat), which can sometimes be life-threatening. In general, allergic reactions can happen within hours to one month after you take Ajovy (fremanezumab). If you notice dizziness, a choking sensation, difficulty breathing, hives, swelling around your eyes, or swelling of the lips or tongue after using Ajovy (fremanezumab), get medical attention right away.

                  dosage

                  Ajovy (fremanezumab) dosage forms

                  The average cost for 1 autoinjector of 225mg/1.5ml of Ajovy (fremanezumab) is $734.24 with a free GoodRx coupon. This is 19.81% off the average retail price of $915.62.
                  autoinjector
                  Autoinjector
                  DosageQuantityPrice as low asPrice per unit
                  225mg/1.5ml1 autoinjector$734.24$734.24
                  syringe
                  Syringe
                  DosageQuantityPrice as low asPrice per unit
                  225mg/1.5ml1 syringe$732.95$732.95

                  Typical dosing for Ajovy (fremanezumab)

                  There are two different dosing options to choose from.

                  • Option 1: Inject 225 mg under the skin once every month.

                  • Option 2: Inject 675 mg under the skin once every 3 months.

                  More on Ajovy (fremanezumab) dosage forms

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                  How much does Ajovy (fremanezumab) cost?

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                  alternatives

                  What are alternatives to Ajovy (fremanezumab)?

                  There are a number of medications that your doctor can prescribe in place of Ajovy (fremanezumab). Compare a few possible alternatives below.
                  Ajovy (fremanezumab)
                  Used for:
                  • Prevention of migraines in adults

                  $732.95 Lowest GoodRx priceView Prices
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                  latest news

                  What is the latest news about Ajovy (fremanezumab)?

                  images

                  Ajovy (fremanezumab) images

                  yellow - AJOVY 225mg / 1.5mL Prefilled Autoinjector Solution for Injection
                  This medicine is Yellow Autoinjector.yellow - AJOVY 225mg / 1.5mL Prefilled Autoinjector Solution for Injection
                  yellow - AJOVY 225mg / 1.5mL Prefilled Autoinjector Solution for Injection
                  This medicine is Yellow Autoinjector.yellow - AJOVY 225mg / 1.5mL Prefilled Autoinjector Solution for Injection

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                  References

                  Best studies we found

                  Dodick, D. W., et al. (2018). Effect of fremanezumab compared with placebo for prevention of episodic migraine: A randomized clinical trial. Journal of the American Medical Association.

                  Silberstein, S. D., et al. (2017). Fremanezumab for the preventive treatment of chronic migraine. The New England Journal of Medicine.

                  Teva Migraine Pregnancy Registry. (2021). About the Teva Migraine Pregnancy Registry.

                  View All References (6)

                  Teva Pharmaceuticals USA, Inc. (2024). Ajovy autoinjector.

                  Teva Pharmaceuticals USA, Inc. (2024). Ajovy prefilled syringe.

                  Teva Pharmaceuticals USA. Inc. (2022). Ajovy- femanezumab-vfrm injection [package insert]. DailyMed.

                  U.S. Food and Drug Administration. (2021). Safely using sharps (needles and syringes) at home, at work and on travel.

                  Wattiez, A., et al. (2020). Calcitonin gene-related peptide (CGRP): Role in migraine pathophysiology and therapeutic targeting. Expert Opinion on Therapeutic Targets.

                  Winner, P. K., et al. (2019). Early onset of efficacy with fremanezumab for the preventive treatment of chronic migraine. Headache.

                  GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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