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Acthib Coupon - Acthib 0.5ml vial

Acthib and Hiberix

haemophilus influenzae type b conjugate vaccine
Used for Bacterial Infection
Used for Bacterial Infection

The Haemophilus influenzae type b (Hib) conjugate vaccine protects you against infections caused by Hib bacteria. ActHIB and Hiberix are different brands of Hib vaccine. Both are injected into the muscles and are typically given as a 3-dose series (plus an additional booster dose) to infants during their routine vaccinations. Sometimes, providers might recommend Hib vaccines for older children and adults with certain health conditions. Some side effects of Hib vaccine include pain at the injection site and sleepiness.

Last reviewed on November 16, 2023
basics-icon

What is Hib vaccine?

What is Hib vaccine used for?

  • Prevention of Hib disease

How Hib vaccine works

Hib vaccine is a conjugate vaccine that helps protect you from Hib disease caused by infection from the Haemophilus influenzae type b bacteria. The vaccine helps your body's immune system make antibodies that will attack the bacteria if it ever infects you.

Are you looking for information on PedvaxHIB (Hib vaccine) 2-dose primary series instead?

Drug Facts

Common BrandsActHIB, Hiberix
Drug ClassVaccine
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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$42.51(save 48.27%)
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$21.99
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What are the side effects of Hib vaccine?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

ActHIB
  • Sleepiness (13-36%)
  • Irritability (13-27%)
  • Tenderness, swelling, hardening at injection site (up to 20%)
  • Lower appetite (6-13%)
Hiberix
  • Irritability (67-70%)
  • Sleepiness (49-60%)
  • Pain, redness, swelling at injection site (up to 49%)
  • Low appetite (28-29%)
  • Fever (14-19%)

Other Side Effects

ActHIB
  • Vomiting
  • Fever

Serious Side Effects

Contact your healthcare provider immediately if you experience any of the following.
  • Serious allergic reaction: hives, rash, nausea, flushing, dizziness, shortness of breath, chest pain

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

pros-and-cons

Pros and cons of Hib vaccine

thumbs-up

Pros

Works well to prevent Hib disease

Readily available and easy to find

Can be given with other vaccines

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Cons

Infant primary series for ActHIB and Hiberix requires 3 doses (plus a booster dose)

Can only be given as an injection into the muscle

Must be given by a healthcare provider at an office, clinic, or pharmacy

pharmacist-tips

Pharmacist tips for Hib vaccine

pharmacist
  • Eligible children can receive Hib vaccine at any facility that's enrolled in the Vaccines for Children Program at no cost. You can also receive Hib vaccine at your provider's office or local pharmacy, or certain community sites (e.g., health clinics, schools, workplaces).

    • Wait until you're healthy to get Hib vaccine. This will help make sure your immune system protects you as best as it can. If you have a mild sickness, such as a cold or low-grade fever, you can still get Hib vaccine. But if you feel moderately to severely sick, wait until you recover before getting this vaccine. Ask your provider if you're not sure whether or not you can get this vaccine.

      • Possible side effects of Hib vaccine include redness, warmth, and swelling at the injection site, and fever. If any of these side effects occur, they usually last for 2 or 3 days.

        • Make sure to mark the dates on your calendar of when you need to go in for all of Hib vaccine injections so that you receive your doses on time and get fully protected against Hib disease.

          • Keep a record of all your immunizations and show it to your provider or pharmacist before receiving any vaccine, including Hib vaccine, to make sure you're receiving all your vaccines on schedule.

            faqs

            Frequently asked questions about Hib vaccine

            What does Hib vaccine protect against?
            Hib vaccine lowers your risk of getting Hib infections. Hib spreads in the air through droplets from the nose and throat of an infected person who coughs or sneezes. Once Hib gets inside your body, it can cause severe infections in different areas, like the brain and lungs. While there are several antibiotics available to treat Hib infections, these infections can also lead to long-term health complications. It's best to receive Hib vaccine for the most protection against Hib.
            What type of vaccine is Hib vaccine?
            Hib vaccine is a conjugate vaccine, which means that it's made of a piece of the bacteria and a protein attached together. Once injected into your body, it helps your immune system make antibodies so you're protected if you ever come in contact with the Hib bacteria.
            What is the difference between ActHIB and Hiberix?
            Both ActHIB and Hiberix are brands of Hib vaccine. They're both 3-dose series that are recommended for infants as routine vaccinations. The only difference is Hiberix can be given to infants as young as 6 weeks of age, whereas the earliest age ActHIB can be given is 2 months.
            What is the difference between ActHIB and PedvaxHIB?
            ActHIB and PedvaxHIB are two brands that work well to prevent Hib disease. The main difference is the number of doses that are needed to complete the primary vaccination. PedvaxHIB is given as a 2-dose series, while ActHIB is a 3-dose series. If appropriate, your child's provider might recommend an additional booster dose, no matter which brand your child receives. Another difference is that ActHIB doesn't contain latex in its packaging, but PedvaxHIB does.
            How long does Hib vaccine last?
            Hib vaccine provides protection against Hib for a long time, though the exact duration isn't clear. If your child has received all doses of Hib vaccine primary series and booster, they typically don't need additional boosters as adults.
            Should children get Hib vaccine?
            Yes, Hib vaccine is a recommended vaccine for all infants starting at 2 months of age. There's also catch-up vaccination recommendations if your child didn't start the series at 2 months of age. This vaccine is recommended to prevent Hib disease, which can be severe and life-threatening. Ask your child's provider about how to start and complete the Hib vaccine series.
            When should you get Hib vaccine?
            The CDC recommends Hib vaccine as a routine vaccine for all infants starting at 2 months of age. It's typically not recommended for older children or adults, unless in special situations. These can include older children who need catch-up vaccination or adults who have weakened immune systems that raise their risk of severe sickness. Ask your provider or pharmacist if you aren't sure if you or your child needs Hib vaccine.
            Does Hib vaccine protect me from the flu?
            No, Hib vaccine protects you from the Haemophilus influenzae bacteria, while the flu vaccine protects you from the influenza (flu) virus. Even though they sound similar, they're totally different pathogens that cause completely different illnesses. Both vaccines are routine for almost everyone to get. If you have further questions, speak to your provider or pharmacist.
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            What are the risks and warnings for Hib vaccine?

            Hib vaccine can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

            risk-warning

            Severe allergic reactions

            • Risk factors: Allergic reaction to other vaccines

              As with any vaccine, there's a rare chance that you might have a severe allergic reaction to Hib vaccine. Your provider might ask you to stay at the pharmacy or clinic for a short period of time after you've received your vaccine to make sure you can get proper care in case of a serious allergic reaction. Sometimes, these reactions can happen after you've already left the clinic. Get medical help right away if you notice symptoms of a severe allergic reaction, such as feeling faint, swelling of the face, closing of the throat, difficulty breathing, hives or rash, dizziness, shaking, nausea, or chest pain.

              risk-warning

              Lower response to Hib vaccine in people with weakened immune systems

              • Risk factors: Medical conditions that weaken the immune system | Taking medications that lower your immune system

                Hib vaccine might not work as well in people with a weakened immune system. This can put you at higher risk of Hib disease, even after you've received the vaccine. If you have any medical conditions (e.g., human immunodeficiency virus (HIV), cancer) or take medications that weaken your immune system (e.g., high-dose corticosteroids, transplant medications), don't get Hib vaccine until you've talked with your provider first.

                risk-warning

                Risk of breathing issues (apnea) in premature babies

                • Risk factors: Premature birth

                  Vaccines that are injected into the muscle, like Hib vaccine, can raise the risk of apnea in babies who were born prematurely. This is a condition where babies have a temporary pause in their breathing, with or without a slowed heart rate or low oxygen level. If your baby was born prematurely, be sure to discuss with your child's provider about the benefits and risks of your child receiving Hib vaccine.

                  risk-warning

                  Fainting

                  • Risk factors: Fainting after receiving vaccines in the past

                    Fainting can happen while or after receiving injectable vaccines, such as Hib vaccine. Signs of fainting include changes in vision, burning or tingling sensation, and stiffening or twitching of your arms and legs. Let your provider know if you've fainted after receiving any vaccine in the past so they can monitor you.

                    risk-warning

                    Guillain-Barre syndrome (GBS)

                    Although rare, some people have reported getting GBS after receiving Hib vaccine. GBS is a rare condition that causes muscle weakness and paralysis. Let your provider know right away if you experience these symptoms or if you've had GBS within 6 weeks of receiving a previous vaccine containing tetanus toxoid.

                    dosage

                    Hib vaccine dosage forms

                    The average cost for 1 vial of 0.5ml of Hib vaccine is $21.99 with a free GoodRx coupon. This is 48.27% off the average retail price of $42.51.
                    vial
                    Vial
                    DosageQuantityPrice as low asPrice per unit
                    0.5ml1 vial$21.99$21.99

                    Typical dosing for Hib vaccine

                    ActHIB and Hiberix

                    Infants

                    • Primary immunization (3-dose series): The typical dose is 1 injection into the muscles at ages 2, 4, and 6 months of age.

                    • Booster: The typical dose is 1 injection, usually between 15 to 18 months old.

                    Please note: Healthcare providers typically give Hib vaccines according to the CDC's recommendations, which differs slightly from manufacturer's directions.

                    Providers might recommend Hib vaccines for adults and older children with certain health conditions.

                    contraindications-icon

                    Hib vaccine contraindications

                    Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Hib vaccine will not be safe for you to take.
                    alternatives

                    What are alternatives to Hib vaccine?

                    There are a number of medications that your doctor can prescribe in place of Hib vaccine. Compare a few possible alternatives below.
                    Hib vaccine
                    Used for:
                    • Prevention of Hib disease

                    $21.99 Lowest GoodRx priceView Prices
                    Used for:
                    • Prevention of Hib disease

                    $40.36 Lowest GoodRx priceView Prices
                    Used for:
                    • Diphtheria

                    • Tetanus

                    • Pertussis (whooping cough)

                    • Poliovirus (or polio)

                    • Haemophilus influenzae type b (Hib)

                    • Hepatitis B

                    $160.46 Lowest GoodRx priceView Prices
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                    Hib vaccine images

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                    References

                    Best studies we found

                    Balloux, F., et al. (2017). Q&A: What are pathogens, and what have they done to and for us? BioMed Central Biology.

                    Centers for Disease Control and Prevention. (2021). About Hib vaccines.

                    Centers for Disease Control and Prevention. (2021). Haemophilus influenzae type b (Hib) VIS.

                    View All References (15)

                    Centers for Disease Control and Prevention. (2021). Hib vaccination

                    Centers for Disease Control and Prevention. (2021). Hib vaccine recommendations.

                    Centers for Disease Control and Prevention. (2022). Haemophilus influenzae Disease Symptoms and Complications.

                    Centers for Disease Control and Prevention. (2022). Haemophilus influenzae disease.

                    Centers for Disease Control and Prevention. (2022). Tetanus vaccination.

                    Centers for Disease Control and Prevention. (2022). About Haemophilus influenzae Disease.

                    Centers for Disease Control and Prevention (2023). About the Vaccines for Children Program (VFC).

                    Centers for Disease Control and Prevention (2023). Child and adolescent immunization schedule by medical indication.

                    Centers for Disease Control and Prevention (2023). Vaccines for Children (VFC) Program information for awardees.

                    GlaxoSmithKline Biologicals SA. (2023). Hiberix (haemophilus b conjugate vaccine- tetanus toxoid conjugate kit [package insert]. DailyMed.

                    GlaxoSmithKline Biologicals SA. (2023). Hiberix- haemophilus b conjugate vaccine (tetanus toxoid conjugate) [package insert]. DailyMed.

                    Nemours Children’s Health. (2023). Apnea of prematurity.

                    Sanofi Pasteur Inc. (2023). Acthib- haemophilus influenzae type b strain 1482 capsular polysaccharide tetanus toxoid conjugate antigen [package insert]. DailyMed.

                    Sanofi Pasteur Inc. (2023). Acthib- haemophilus influenzae type b strain 1482 capsular polysaccharide tetanus toxoid conjugate antigen [package insert]. DailyMed.

                    U.S. Department of Health and Human Services. (2021). Hib (Haemophilus influenzae type B).

                    GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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