Acetaminophen/Diphenhydramine/Phenylephrine Dosage

There are several manufacturers of this medication with different strengths of each ingredient, different dosage forms (e.g., tablet, solution), and different age cut-offs. The dose might slightly differ depending on which manufacturer of the medication you choose. Be sure to check the medication box carefully for specific directions. Ask your pharmacist if you have any questions about your product.

Examples include:

Robitussin Severe Multi-Symptom Cough Cold and Flu and its generic solution

Each 20 mL of solution contains 650 mg of acetaminophen, 25 mg of diphenhydramine, and 10 mg of phenylephrine.

• Adults and children 12 years and older: The typical dose is 20 mL by mouth every 4 hours. Don't take more than 6 doses in a 24-hour period.
• Children under 12 years old: Don't use.

Generic acetaminophen / diphenhydramine / phenylephrine caplets

Each caplet contains 325 mg of acetaminophen, 12.5 mg of diphenhydramine, and 5 mg of phenylephrine.

• Adults and children 12 years and older: The typical dose is 2 caplets by mouth every 4 hours. Don't take more than 10 caplets in a 24-hour period.
• Children under 12 years old: Ask your child's provider.