Yuvezzi
Yuvezzi (carbachol / brimonidine) is a prescription eye drop used to treat adults with presbyopia, an age-related condition that makes it harder for you to see things up close. It combines two medications, carbachol (a cholinergic agonist) and brimonidine (an alpha-2 agonist), that work together to help improve your near vision. The usual dose is 1 drop in each eye once a day. Common side effects include headache, blurry vision, and temporary eye irritation or eye pain.
What is Yuvezzi (carbachol / brimonidine)?
What is Yuvezzi (carbachol / brimonidine) used for?
- Presbyopia (age-related farsightedness) in adults
How Yuvezzi (carbachol / brimonidine) works
Yuvezzi (carbachol / brimonidine) is a combination eye drop containing two medications:
- Carbachol is a cholinergic agonist that makes the muscles in your eye tighten, causing your pupil to become smaller.
- Brimonidine is an alpha-2 agonist that helps keep your pupil small by blocking the muscle that normally makes it larger.
Together, these medications create a "pinhole effect" by making your pupil smaller. This helps improve your ability to see things up close and can make reading and other close-up tasks easier.
Drug facts
| Common Brands | Yuvezzi |
|---|---|
| Drug Class | Cholinergic agonist / alpha-2 agonist |
| Controlled Substance Classification | Not a controlled medication |
| Generic Status | No lower-cost generic available |
| Availability | Prescription only |
Side effects of Yuvezzi (carbachol / brimonidine)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Headache (16%)
- Eye irritation after use (14%)
- Eye pain after use (7%)
- Vision problems (6%)
Yuvezzi (carbachol / brimonidine) serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Retinal tear or retinal detachment: flashes of light, new floaters, sudden vision loss, a curtain-like shadow over the vision
The following Yuvezzi (carbachol / brimonidine) side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Blurry vision, vision loss, seeing wavy or bent objects or blind spots with dark, light, or flashing spots
- New or worsening eye pain, redness, irritation, or discharge
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Blurry vision
- Burning or stinging of the eyes after use
- Headache
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Pros and cons of Yuvezzi (carbachol / brimonidine)
Pros
- Only need to use once a day
- Combines two medications into one
- Works within minutes to a few hours
Cons
- Can sting or irritate your eyes after application
- Can cause headaches
- Might temporarily blur vision
Pharmacist tips for Yuvezzi (carbachol / brimonidine)
- Use 1 drop of Yuvezzi (carbachol / brimonidine) each eye once a day. Taking extra doses won’t help your eyes work better, and it can raise the chance of side effects.
- Don’t drive or do activities that need clear vision until you know how Yuvezzi (carbachol / brimonidine) affects you. It can temporarily cause blurry, dim, or dark vision, especially at night.
- Call your eye specialist right away if you notice flashes of light, floaters, or sudden vision loss while using Yuvezzi (carbachol / brimonidine). These can be signs of serious eye problems such as a retinal tear or retinal detachment.
- Remove your contact lenses before using Yuvezzi (carbachol / brimonidine). Wait at least 10 minutes before putting your contacts back in so the medication has time to absorb.
- If you use other eye medications, space them apart from Yuvezzi (carbachol / brimonidine). Wait at least 5 minutes between eye drops so one medication doesn’t wash out the other.
- Storage: Store Yuvezzi (carbachol / brimonidine) in the refrigerator or at room temperature. Once you open a foil pouch, keep the unused single-dose vials inside the pouch and away from light until you’re ready to use them.
How to use Yuvezzi (carbachol / brimonidine):
- Wash your hands before to help prevent eye infections.
- Open 1 single-dose vial and place 1 drop into each eye. Use the vial right away after opening it.
- Don’t let the vial tip touch your eye, eyelid, fingers, or any other surface. Throw away the vial after use, even if there is medication left inside.
Risks and warnings for Yuvezzi (carbachol / brimonidine)
Yuvezzi (carbachol / brimonidine) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Blurry vision
Yuvezzi (carbachol / brimonidine) can make your vision blurry for a while after you use it. It can also make your vision look dim or dark, especially in poor lighting.
Be careful with driving at night or doing anything that needs clear vision right away after a dose. If your vision isn’t clear, don’t drive or use machinery until it improves.
Retinal tear or retinal detachment
- Risk factors: History of retinal conditions
Rare cases of serious eye problems, such as retinal tear and retinal detachment, have been reported with eye drops like Yuvezzi (carbachol / brimonidine). Your risk might be higher if you already have certain retinal conditions.
Keep your regular eye appointments so your eye specialist can check your eye health. Get medical help right away if you notice flashes of light, new floaters, or sudden vision loss.
Existing eye inflammation
Yuvezzi (carbachol / brimonidine) isn't recommended if you have iritis, which is inflammation inside the eye. That’s because this medication can worsen inflammation and raise the risk of other eye problems. Tell your care team if you notice worsening redness, pain, or sensitivity to light during treatment.
Worsen blood flow problems
- Risk factors: Depression | Low blood flow to the brain or heart | Raynaud’s phenomenon | Low blood pressure when standing | Buerger disease
Yuvezzi (carbachol / brimonidine) can worsen conditions linked to poor blood flow. Tell your eye specialist if you have a history of circulation problems, low blood pressure, or depression before you start treatment. If you feel dizzy, faint, or notice your circulation symptoms getting worse, contact your care team.
Use properly to avoid eye injury and eye infections
Be careful not to let the bottle tip touch your eye or any other surface. This helps you avoid eye injury. It also helps prevent the medication from getting contaminated with germs, which helps prevent eye infections.
Yuvezzi (carbachol / brimonidine) dosage
Vial| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 0.16ml of 2.75%/ 0.1% | 30 vials | $79.99 | $2.67 |
Typical dosage for Yuvezzi (carbachol / brimonidine)
The typical dose is 1 drop in each eye once a day.
How much does Yuvezzi (carbachol / brimonidine) cost?
$79.99
What are alternatives to Yuvezzi (carbachol / brimonidine)?
Yuvezzi (carbachol / brimonidine) images
