Type your drug name (like Atorvastatin, Sildenafil, etc)

Specialty Drug

DENOSUMAB slows bone breakdown. Prolia is used to treat osteoporosis in women after menopause and in men, and in people who are taking corticosteroids for 6 months or more. Xgeva is used to treat a high calcium level due to cancer and to prevent bone fractures and other bone problems caused by multiple myeloma or cancer bone metastases. Xgeva is also used to treat giant cell tumor of the bone. Compare RANKL inhibitors.

Prescription Settings

Xgeva Side Effects

What should I watch for?

Visit your doctor or health care professional for regular checks on your progress. Your doctor or health care professional may order blood tests and other tests to see how you are doing.

Call your doctor or health care professional for advice if you get a fever, chills or sore throat, or other symptoms of a cold or flu. Do not treat yourself. This drug may decrease your body's ability to fight infection. Try to avoid being around people who are sick.

You should make sure you get enough calcium and vitamin D while you are taking this medicine, unless your doctor tells you not to. Discuss the foods you eat and the vitamins you take with your health care professional.

See your dentist regularly. Brush and floss your teeth as directed. Before you have any dental work done, tell your dentist you are receiving this medicine.

Do not become pregnant while taking this medicine or for 5 months after stopping it. Talk with your doctor or health care professional about your birth control options while taking this medicine. Women should inform their doctor if they wish to become pregnant or think they might be pregnant. There is a potential for serious side effects to an unborn child. Talk to your health care professional or pharmacist for more information.

Common and Rare Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Back pain

blistering, crusting, irritation, itching, or reddening of the skin

bloody or cloudy urine

cracked, dry, or scaly skin

difficult, burning, or painful urination

frequent urge to urinate

muscle or bone pain

pain in the arms or legs

rash

skin rash, encrusted, scaly, and oozing

swelling

Less common

Arm or jaw pain

bloating or swelling of the face, arms, hands, lower legs, or feet

body aches or pain

chest pain or discomfort

chest tightness or heaviness

chills

confusion

congestion

cough

difficulty with breathing

difficulty with moving

dryness or soreness of the throat

ear congestion

fast or irregular heartbeat

fever

headache

hoarseness

joint pain

loss of voice

muscle cramps in the hands, arms, feet, legs, or face

muscle stiffness

numbness and tingling around the mouth, fingertips, hands, or feet

pain in the lower back, bottom, upper leg, or hips

painful blisters on the trunk of the body

pale skin

rapid weight gain

runny or stuffy nose

seizures

sneezing

stomach cramps

swollen joints

tender, swollen glands in the neck

tremor

trouble swallowing

troubled breathing with exertion

unusual bleeding or bruising

unusual tiredness or weakness

unusual weight gain or loss

voice changes

Rare

Blood in the stool

change in bowel habits

clear or bloody discharge from the nipple

constipation

darkened urine

difficulty with eating

dimpling of the breast skin

indigestion

inverted nipple

itching, pain, redness, swelling, tenderness, or warmth on the skin

loss of appetite

lower back or side pain

lump in the breast or under the arm

lump or swelling in the abdomen or stomach

nausea

pains in the stomach, side, or abdomen, possibly radiating to the back

persistent crusting or scaling of the nipple

raised, firm, and bright red patches of the skin on the arm or leg

redness or swelling of the breast

sore on the skin of the breast that does not heal

stomach discomfort

unexplained weight loss

vomiting

yellow eyes or skin

Incidence not known

Heavy feeling in the jaw

loose teeth

pain, swelling, or numbness in the mouth or jaw

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Dizziness or lightheadedness

excess air or gas in the stomach or bowels

feeling of constant movement of self or surroundings

feeling of fullness

heartburn

lack or loss of strength

passing gas

redness, pain, itching, burning, swelling, or a lump under your skin where the shot was given

sensation of spinning

trouble sleeping

upper abdominal or stomach pain

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

Other RANKL inhibitors

Other Conditions

Breast Cancer

Lung Cancer

Prostate Cancer

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