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Xdemvy Coupon - Xdemvy 10ml of 0.25% eye dropper

Xdemvy

lotilaner
Used for Eye Inflammation
Used for Eye Inflammation

Xdemvy (lotilaner) is an eye drop used to treat adults with Demodex blepharitis, an eye condition caused by tiny mites that live on the eyelids that lead to redness, irritation, and crusty buildup. It's an antiparasitic that works by paralyzing and killing the mites. You use one drop in each eye twice a day, about 12 hours apart, for 6 weeks. A common side effect is a stinging or burning feeling right after use. There is no generic version available at this time.

Reviewed by:
reviewer
Allison Gourley, PharmD
reviewer
Daisy Chau, PharmD
Last reviewed on August 5, 2025
BasicsSide effectsPros & consPharmacist tipsFAQsWarningsDosageAlternativesImagesReferencesPricesMedicare
basics-icon

What is Xdemvy (lotilaner)?

What is Xdemvy (lotilaner) used for?

How Xdemvy (lotilaner) works

Xdemvy (lotilaner) is an antiparasitic. It works by acting on the nervous system of Demodex mites, paralyzing and killing them to help relieve symptoms.

When does Xdemvy (lotilaner) start working?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Full effect

Drug Facts

Common BrandsXdemvy
Drug ClassAntiparasitic
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityPrescription only
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What are the side effects of Xdemvy (lotilaner)?

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Burning sensation in the eyes (10%)
  • Stinging sensation in the eyes (10%)

Other Side Effects

When do Xdemvy (lotilaner) possible side effects begin and end?
Time passed since treatment started:
MINUTES
HOURS
DAYS
WEEKS
MONTHS
Burning sensation
Stinging sensation

Source: DailyMed

The following side effects have also been reported

Side effects that you should report to your care team as soon as possible:

Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

  • Burning or stinging of the eyes after use
pros-and-cons

Pros and cons of Xdemvy (lotilaner)

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Pros

The only FDA-approved treatment for Demodex blepharitis

Not many serious side effects

Can be stored at room temperature

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Cons

Need to use for the full 6 week course

Must apply to both eyes twice a day

Only available through certain specialty pharmacies

pharmacist-tips

Pharmacist tips for Xdemvy (lotilaner)

pharmacist

  • Be careful not to let the tip of the Xdemvy (lotilaner) bottle touch your eye, eyelid, fingers, or anything else. This helps keep the drops clean and free of germs. Using contaminated eye drops could seriously harm your eye or even affect your vision.

    • If you miss a dose of Xdemvy (lotilaner), skip it and use your next dose at the regular time. Don’t use extra drops to make up for the one you missed.

      • If you get an eye injury, infection, have eye surgery, or notice redness, swelling, or other unusual changes while using Xdemvy (lotilaner), contact your care team right away. Your prescriber will let you know if you should keep using the drops.

        • Take your contacts out before using Xdemvy (lotilaner). The preservative in the drops can stain soft contact lenses. You can put them back in after 15 minutes after using the drops.

          • You can use Xdemvy (lotilaner) with other eye drops, but wait at least 5 minutes between each one. This helps each medication get fully absorbed.

            • Store Xdemvy (lotilaner) at room temperature. Don't store it in the refrigerator since it might damage it.

              faqs

              Frequently asked questions about Xdemvy (lotilaner)

              Is Xdemvy (lotilaner) safe?
              Yes, Xdemvy (lotilaner) is generally safe for most people when used as directed. It doesn't cause many serious side effects. In studies, about 10% of people felt burning or stinging in the eye right after using the drops. If you have any concerns or your symptoms get worse, talk to your prescriber.
              Is Xdemvy (lotilaner) a steroid?
              No, Xdemvy (lotilaner) isn't a steroid medication, it's an antiparasitic. Unlike steroids, which reduce inflammation by calming the immune system, Xdemvy (lotilaner) works by targeting and killing Demodex mites, which cause blepharitis (eyelid inflammation).
              Does Xdemvy (lotilaner) cure blepharitis?
              While it might cure blepharitis for good, Xdemvy (lotilaner) can help treat and greatly reduce the symptoms of Demodex blepharitis. In studies, many people had less redness and crusting after using it twice a day for 6 weeks. But because blepharitis can come back, symptoms might return, and you might need another round of treatment. Always follow your prescriber's advice for the best long-term care.
              How long does Xdemvy (lotilaner) take to work?
              Xdemvy (lotilaner) usually starts working within a few weeks, but the full effect is usually seen by 6 weeks. Some people might notice improvement earlier, but it’s important to finish the full treatment for the best results. If you don't see an improvement by the end of treatment, speak with your prescriber.
              When was Xdemvy (lotilaner) FDA approved?
              Xdemvy (lotilaner) was approved in July 2023 for the treatment of Demodex blepharitis.
              How effective is Xdemvy (lotilaner)?
              Xdemvy (lotilaner) is very effective at treating Demodex blepharitis. In studies, 50% of people had less crusty buildup on their eyelashes. And about 60% of people had all of their Demodex mites completely gone after using it. While results can vary, most people see clear improvement when using it twice a day for 6 weeks as directed.
              Can I get Xdemvy (lotilaner) over the counter (OTC)?
              No, Xdemvy (lotilaner) is only available with a prescription from a healthcare professional. You can't get it over the counter, especially since it's only available through certain specialty pharmacies.
              How often can Xdemvy (lotilaner) be used?
              Use only one drop of Xdemvy (lotilaner) in each eye twice a day, about 12 hours apart, for 6 weeks. It's not known if using it longer than that is safe. Follow your prescriber’s instructions and don’t use more than directed.
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              What are the risks and warnings for Xdemvy (lotilaner)?

              Xdemvy (lotilaner) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

              risk-warning

              Risk of contamination

              Don't let the tip of the Xdemvy (lotilaner) bottle touch your eye, eyelid, fingers, or any surface. This helps keep the drops clean and prevents germs from getting into the bottle. Using contaminated drops could seriously harm your eye or even affect your vision.

              risk-warning

              Color change in contact lenses

              • Risk factors: Wearing soft contact lenses

                The preservative in Xdemvy (lotilaner) can change the color of your soft contact lenses. To avoid this, take your lenses out before using the drops. Wait 15 minutes before putting your lenses back in.

                dosage

                Xdemvy (lotilaner) dosage forms

                Typical dosing for Xdemvy (lotilaner)

                The typical dose is one drop in each eye twice daily (12 hours apart) for 6 weeks.

                alternatives

                What are alternatives to Xdemvy (lotilaner)?

                There are a number of medications that your doctor can prescribe in place of Xdemvy (lotilaner). Compare a few possible alternatives below.
                Xdemvy (lotilaner)
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                Hypochlorous acid
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                images

                Xdemvy (lotilaner) images

                yellow - Xdemvy 0.25% Ophthalmic Solution
                This medicine is Yellow Eye Dropper.yellow - Xdemvy 0.25% Ophthalmic Solution

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                References

                Best studies we found

                Burkat, C. N., et al. (2025). Demodex Infestation. American Academy of Ophthalmology.

                Food and Drug Administration. (2024). Drug Trials Snapshots: XDEMVY.

                Tarsus Pharmaceuticals, Inc. (n.d.). Discover the XDEMVY® Effect.

                View All References (5)

                Tarsus Pharmaceuticals, Inc. (n.d.). Supporting your XDEMVY® prescription experience: Navigating XDEMVY access and savings.

                Tarsus Pharmaceuticals, Inc. (2023). FDA approves XDEMVY™ (lotilaner ophthalmic solution) 0.25% for the treatment of Demodex blepharitis. Globe Newswire.

                Tarsus Pharmaceuticals, Inc. (2024). Xdemvy- lotilaner ophthalmic solution solution/drops [package insert]. DailyMed.

                Yeu, E., et al. (2023). Lotilaner ophthalmic solution, 0.25%, for the treatment of Demodex blepharitis: Results of a prospective, randomized, vehicle-controlled, double-masked, pivotal trial (Saturn-1). Cornea.

                Yeu, E., et al. (2025). Safety and Efficacy of Lotilaner Ophthalmic Solution (0.25%) in Treating Demodex Blepharitis: Pooled Analysis of Two Pivotal Trials. Ophthalmology and Therapy.

                GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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