Key takeaways:
Vimpat (lacosamide) is medication that treats seizures in adults and children ages 1 month and over.
The typical starting Vimpat dosage for adults is 50 mg to 100 mg twice daily. From there, your provider may slowly increase your dosage up to a maximum of 200 mg twice daily if needed. The Vimpat dosage for children is based on body weight.
In some cases, your provider may have you take a one-time dose of Vimpat that’s higher than your typical daily dose. This helps Vimpat start working faster. But it can also cause more side effects, so it’s not recommended for everyone.
Vimpat is available as a lower-cost generic. GoodRx can help you save over 90% off the average retail price of generic Vimpat at certain pharmacies.
Vimpat (lacosamide) is a prescription medication that treats certain types of seizures. It’s approved for both children and adults and can be taken alone or along with other anti-seizure medications.
The recommended Vimpat dosage depends on your age and why you’re taking it. We’ll look at the recommended dosages below. But your healthcare provider may have you take a different Vimpat dosage than described here. It’s best to follow their instructions and reach out with any questions.
Vimpat comes in two oral forms: tablets and a liquid solution. You can take Vimpat with or without food. But taking it with a meal or snack may help prevent nausea, a known Vimpat side effect.
Vimpat oral tablets come in four doses:
50 mg
100 mg
150 mg
200 mg
Vimpat also comes as a strawberry-flavored oral solution that contains 10 mg per 1 mL. The solution may be a better option for young children or adults who have trouble swallowing tablets. Be sure to measure the oral solution with a syringe or measuring device from your pharmacy. A household spoon won’t measure Vimpat accurately.
You can keep the oral solution at room temperature, but you shouldn’t use it more than 6 months after the bottle is opened.
Good to know: Vimpat also comes in an injectable form. But it’s typically given in a hospital setting.
The typical Vimpat dosage for adults (17 years and older) depends on why you’re taking it. It also depends on whether you’re taking it alone (monotherapy) or with another anti-seizure medication (adjunctive therapy).
The recommended Vimpat dosage as a solo treatment for partial-onset seizures in adults starts at 100 mg twice daily. You’ll then slowly increase your dose to the recommended amount of 150 mg to 200 mg twice daily. Doses over 400 mg daily aren’t recommended.
There should be at least 1 week between each increase in dosage. And it’s not recommended to raise the dose by more than 50 mg per dose (100 mg per day) at a time.
In some cases, you’ll start with a single 200 mg dose of Vimpat, called a loading dose. You’ll then start the above dosage schedule 12 hours later. This helps Vimpat start working faster, but it can also raise your risk of side effects, such as headache, dizziness, and drowsiness. Your healthcare provider will help decide if a loading dose is needed.
If you’re taking Vimpat with other anti-seizure medication (adjunctive therapy), your recommended daily dose is lower than if you’re taking it alone. You’ll start with 50 mg twice daily, then slowly increase to the recommended amount of 100 mg to 200 mg twice daily.
There should be at least 1 week between each dosage increase. And it’s not recommended to raise the dose by more than 50 mg per dose (100 mg per day) at a time.
In some cases, your provider may recommend a 200 mg loading dose of Vimpat. Then, 12 hours later, you’ll start taking 100 mg twice daily. This can help Vimpat start working faster. If needed, your dose can be increased up to a maximum of 200 mg twice daily as described above.
The typical Vimpat dosage for children under the age of 17 is based on their body weight. It may also depend on whether Vimpat is the only anti-seizure medication they’re taking or if it’s being combined with others.
Vimpat is approved as monotherapy and adjunctive therapy for partial-onset seizures in children ages 1 month and older. But adjunctive therapy for tonic-clonic seizures is only approved for children ages 4 and older.
Body weight | Starting dosage | Goal dosage |
---|---|---|
50 kg (110 lbs) or more | 50 mg twice daily | Monotherapy*: 150 mg - 200 mg twice daily Adjunctive therapy: 100 mg - 200 mg twice daily |
Less than 50 kg - 30 kg | 1 mg/kg twice daily | Monotherapy / adjunctive therapy: 2 mg/kg - 4 mg/kg twice daily |
Less than 30 kg - 6 kg | 1 mg/kg twice daily | Monotherapy / adjunctive therapy*: 3 mg/kg - 6 mg/kg twice daily |
Less than 6 kg (13 lbs) | 1 mg/kg twice daily | Monotherapy*: 3.75 mg/kg - 7.5 mg/kg twice daily |
*Partial-onset seizures only
The Vimpat dosage for children should be slowly increased by no more than 1 mg/kg per dose (2 mg/kg per day) each week.
If a loading dose is given, your child will start their twice daily dosage 12 hours afterward. Your child’s healthcare provider will help decide whether a loading dose is needed.
If you have other medical conditions, like kidney or liver problems, your recommended Vimpat dosage may change.
If you have kidney problems, it may be harder for your body to clear Vimpat. This can increase Vimpat levels and make side effects more likely. If you have severe kidney problems, your healthcare provider may lower your Vimpat dosage by 25%. They can help decide if you need a lower dose of Vimpat based on your kidney function.
A 25% lower dosage of Vimpat is also recommended if you have mild or moderate liver problems. But if your liver problems are severe, Vimpat isn’t recommended. Your provider will help determine if you need a lower Vimpat dosage based on your liver function.
If you realize you've missed a dose of Vimpat, take it as soon as you remember. But if it's almost time for your next dose, skip the missed dose and take the next one as scheduled. Don’t try to make up for the missed dose by taking two doses at once.
Remember, consistency is key when it comes to Vimpat. Taking your doses at the same time each day helps maintain a steady level of the medication in your body. This helps it work effectively.
If you're having trouble remembering to take your medication, try setting a reminder on your phone or using a pillbox. You can also talk to your pharmacist or healthcare provider. They may be able to suggest strategies to help you remember.
If you take an extra dose of Vimpat by mistake, it’s not likely to cause a problem. You may have more side effects than usual, such as dizziness or blurry vision. They should go away as your dose wears off.
But taking a large amount of Vimpat can be dangerous and even life-threatening in some cases. Symptoms can include dizziness, nausea, and seizures. Confusion, heart problems, or a coma are also possible. In severe cases, a Vimpat overdose can be fatal.
If you or your child takes too much Vimpat, seek medical attention immediately or call Poison Control at 1-800-222-1222. Do not wait for symptoms to appear.
Vimpat is available as both a brand-name and generic medication. GoodRx can help you save over 90% off the average retail price of the generic version. Generic Vimpat’s price at certain pharmacies is as low as $28.47 with a free GoodRx discount.
Vimpat (lacosamide) is a prescription medication that treats certain types of seizures in adults and children. The usual starting Vimpat dosage for adults is 50 mg to 100 mg twice daily, depending on whether you’re taking it alone or with other seizure medications. From there, it can be increased up to a maximum of 200 mg twice daily if needed. The Vimpat dosage for children 16 and under is based on body weight.
If you have liver or kidney problems, you may need a lower Vimpat dosage.
In some cases, your healthcare provider may have you start with a single loading dose of Vimpat that’s higher than your twice daily dosage. This can help Vimpat start working faster, but it may cause more side effects. Your healthcare provider will help determine the best dosage for you.
Kiriakopoulos, E., et al. (n.d.). Focal onset aware seizures (simple partial seizures). Epilepsy Foundation.
Kiriakopoulos, E., et al. (2017). Tonic-clonic seizures. Epilepsy Foundation.
Malissin, I., et al. (2013). Fatal lacosamide poisoning in relation to cardiac conduction impairment and cardiovascular failure. Clinical Toxicology.
MedlinePlus. (2022). Lacosamide.
UCB, Inc. (2023). Vimpat [package insert].
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