Isoxsuprine is a vasodilator. It works to improve blood flow by opening up the blood vessels. It can be used to treat [peripheral vascular disease](https://www.ncbi.nlm.nih.gov/books/NBK557482/), such as [Buerger's disease](https://rarediseases.org/rare-diseases/buergers-disease/) and [Raynaud's disease](https://www.goodrx.com/conditions/raynauds-phenomenon). Isoxsuprine also helps to treat people with low blood flow to the brain (cerebrovascular insufficiency).

Is isoxsuprine still available?

No, isoxsuprine has been [discontinued](https://www.fda.gov/media/153825/download) as of August 2021 and is no longer available in the United States.

Why was isoxsuprine discontinued?

[Isoxsuprine](https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1f67beb8-af30-4c88-8e36-638b0f12adaf) was discontinued because the FDA determined there [wasn't enough evidence](https://www.fda.gov/drugs/fda-notification-regarding-isoxsuprine-hydrochloride-drug-products) to support its use, so it wasn't clear how well isoxsuprine works.

What medications are used in place of isoxsuprine?

There are [other options](https://www.goodrx.com/conditions/peripheral-artery-disease#medications) available that can be used to improve blood flow to the body, such as [cilostazol (Pletal)](https://www.goodrx.com/cilostazol/what-is), as well as [stroke risk reduction medications](https://www.goodrx.com/conditions/stroke-risk-reduction/drugs). Your provider can help guide you to the best treatment option for your condition.

isoxsuprine

Generic Vasodilan (brand no longer available)

Used for Peripheral Artery Disease, Raynaud's Phenomenon

Basics FAQs Dosage Interactions Alternatives References Prices Medicare

Isoxsuprine is an oral medication that's used to improve blood flow to certain parts of the body. It's no longer available in the United States because it was discontinued.

Reviewed by:

Robert Chad Hakim, PharmD, BCCCP

Kristianne Hannemann, PharmD

Last reviewed on January 4, 2023

Basics FAQs Dosage Interactions Alternatives References Prices Medicare

What is Isoxsuprine?

What is Isoxsuprine used for?

To improve blood flow to the brain (cerebrovascular insufficiency)
To improve blood flow to the arms, legs, fingers, and toes (peripheral vascular disease)

Drug facts

Common BrandsVasodilan(brand no longer available)

Drug ClassVasodilator

Controlled Substance ClassificationNot a controlled medication

Generic StatusNo lower-cost generic available

AvailabilityPrescription only

Common questions about Isoxsuprine

Isoxsuprine is a vasodilator. It works to improve blood flow by opening up the blood vessels. It can be used to treat peripheral vascular disease, such as Buerger's disease and Raynaud's disease. Isoxsuprine also helps to treat people with low blood flow to the brain (cerebrovascular insufficiency).

No, isoxsuprine has been discontinued as of August 2021 and is no longer available in the United States.

Isoxsuprine was discontinued because the FDA determined there wasn't enough evidence to support its use, so it wasn't clear how well isoxsuprine works.

There are other options available that can be used to improve blood flow to the body, such as cilostazol (Pletal), as well as stroke risk reduction medications. Your provider can help guide you to the best treatment option for your condition.

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Isoxsuprine dosage

Typical dosage for Isoxsuprine

Interactions between Isoxsuprine and other drugs

Isoxsuprine may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Isoxsuprine. Please note that only the generic name of each medication is listed below.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.

What are alternatives to Isoxsuprine?

There are a number of medications that your doctor can prescribe in place of Isoxsuprine. Compare a few possible alternatives below.

Isoxsuprine

Used for:

To improve blood flow to the brain (cerebrovascular insufficiency)
To improve blood flow to the arms, legs, fingers, and toes (peripheral vascular disease)

View prices

Pentoxifylline ER

Used for:

Intermittent claudication (pain in your legs when you walk or exercise)

$21.72Lowest GoodRx priceView prices

Cilostazol

Used for:

Intermittent claudication (pain in legs when you walk or exercise)

$24.00Lowest GoodRx priceView prices

References

Best studies we found

American Association of Neurological Surgeons. (n.d.). Cerebrovascular disease.

Becker, C. (2021). Cease distribution letter - Isoxsuprine hydrochloride tablets, USP, 10 and 20 mg. U.S. Food and Drug Administration.

Gul, F., et al. (2023). Peripheral vascular disease. StatPearls.

GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.

isoxsuprine