Key takeaways:
Twyneo (tretinoin / benzoyl peroxide) is a topical cream that treats acne in adults and children ages 9 and older.
Without insurance, the average retail price of Twyneo is $807.53 per bottle. A manufacturer copay savings card can help lower the cost of Twyneo, whether or not you have insurance coverage. A free GoodRx discount can also help reduce the cost.
Medicaid and commercial insurance plans are more likely to cover Twyneo than Affordable Care Act (ACA) marketplace or Medicare plans. Prior authorization is also a common requirement for many plans.
Save on related medications
Twyneo (tretinoin / benzoyl peroxide) is a topical cream that treats acne in adults and children ages 9 and older. Its two active ingredients work in combination to reduce and prevent breakouts.
How much you’ll pay for Twyneo depends on several factors. Here, we’ll review how much Twyneo costs without insurance, how often insurance plans cover it, and ways to save on the cost of your prescription.
How much does Twyneo cost without insurance?
Twyneo comes in a 30 g bottle with a built-in pump. Without insurance, the average retail price of Twyneo is $807.53 per bottle. But in some cases, the out-of-pocket cost may be up to $1,000 or more.
What factors affect the cost of Twyneo?
How much you’ll pay for Twyneo depends on several factors, such as:
Location: Where you live can make a difference in the cost of your prescription medications. For example, prescriptions typically cost more in New Orleans than in Denver, according to GoodRx research.
Pharmacy: Which pharmacy you choose can also play a role in the out-of-pocket costs of your medications. GoodRx can help you compare prices at different pharmacies to find the most affordable option in your area.
Insurance coverage: If you have prescription medication insurance that covers Twyneo, what you pay may be determined by your copay or coinsurance. The amount will depend on where your plan places Twyneo within its formulary. Medications placed in a lower formulary tier are generally more affordable than those in a higher tier.
Discounts: Manufacturer copay savings cards and free prescription savings discounts, such as those offered by GoodRx, can help lower the cost of Twyneo.
Does insurance cover Twyneo? [Insurance coverage]
Twyneo is covered by most Medicaid plans, but you’ll likely need to get prior authorization first. This means your prescriber will need to submit information explaining why Twyneo is medically necessary before your plan will cover it.
A little more than half of commercial insurance plans and about one-third of Affordable Care Act (ACA) marketplace plans cover Twyneo. Prior authorization is required for most ACA plans that cover Twyneo. But it isn’t as common with commercial plans.
Step therapy isn’t a common requirement with any type of insurance plan. But it’s possible that you may need to try other treatments (or explain why you aren’t able to take them) before Twyneo will be covered.
Most Medicare plans don’t cover Twyneo. That’s because Medicare typically only covers dermatology-related conditions that significantly impact health.
How different insurance plans cover Twyneo
The table below breaks down the percentage of enrollees who have coverage for Twyneo by insurance type. It also shows the likelihood of having prior authorization and step therapy requirements.
Insurance type | Enrollees covered for Twyneo | Enrollees required to get prior authorization | Enrollees required to do step therapy |
31% | 25.2% | 12.8% | |
Commercial plans (excluding ACA plans) | 61.9% | 17.9% | 12.7% |
Medicare (Medicare Advantage and Part D plans) | 7.3% | 3.4% | 1.1% |
Medicaid, including state-run and managed care plans | 98.9% | 93.9% | 9.4% |
Source: Managed Markets Insight & Technology, LLC™, as of January 10, 2026. (See methodology below.)
If your insurance doesn’t cover Twyneo, try these options:
See if you can lower the cost with a copay savings card or savings discount (discussed below).
Ask your insurance plan to cover Twyneo by submitting a formulary exception request. Your prescriber may need to provide documentation and a letter of medical necessity explaining why this medication is required for your condition.
If the formulary exception request is denied, file an appeal.
Ask your prescriber about switching to a Twyneo alternative that’s available as a lower-cost generic, such as Epiduo (adapalene / benzoyl peroxide).
Compare insurance plans during the next open enrollment period to find one that offers coverage for Twyneo.
Ways to save on Twyneo
Here are three ways you may be able to save on Twyneo.
1. Use a GoodRx coupon
A free GoodRx discount could help you save up to 40% off the cost of Twyneo. Visit www.goodrx.com or download the GoodRx app to take advantage of these savings.
Let your pharmacy know you’d like to use a GoodRx discount before you pick up your medication. Providing them with this information in advance can help you avoid unnecessary delays at the pharmacy counter.
2. See if you qualify for a copay savings card
If you have commercial insurance, you may be able to pay as little as $0 for Twyneo using a savings card from the manufacturer. If you don’t have insurance coverage, you may pay as little as $45 per bottle using this savings card.
To be eligible, you must:
Have a valid prescription for Twyneo
Be at least 18 years old but younger than 65
Have a commercial medical or prescription insurance plan
Not be enrolled in a government-sponsored insurance program, such as Medicare or Medicaid
Be a U.S. resident
Meet your yearly deductible
3. Tap into your HSA, FSA, or HRA
If you have a health savings account (HSA), a flexible spending account (FSA), or a health reimbursement arrangement (HRA), you can use it to help cover your out-of-pocket costs for Twyneo. These tax-advantaged health accounts let you pay for eligible expenses with tax-free dollars.
You can pay for your medication directly with an HSA or FSA card, or cover the cost yourself and submit a request for reimbursement. The funds in an HSA or an HRA typically roll over annually, but you generally have to use FSA dollars before the deadline.
The bottom line
Twyneo (tretinoin / benzoyl peroxide) is a topical cream that treats acne in adults and children ages 9 and older. Without insurance, the average retail price of Twyneo is $807.53 per bottle. But how much you pay can depend on factors like where you live and what pharmacy you choose.
Medicaid and commercial insurance plans are more likely to cover Twyneo than Affordable Care Act (ACA) marketplace or Medicare plans. Prior authorization is also a common requirement for many plans.
A manufacturer copay savings card could help lower the cost of Twyneo, whether or not you have insurance coverage. A free GoodRx discount could also help reduce your costs.
Why trust our experts?
Methodology
We obtained national prescription coverage data for each medication from Managed Markets Insight & Technology (MMIT). The data reflects health insurance coverage as of January 2026.
We calculated the percentage of enrollees in plans that cover each medication by dividing the number of enrollees covered for the medication within a specific insurance channel (e.g., ACA, Medicare, Medicaid) by the total number of enrollees in all plans within that channel.
We determined the percentage of enrollees in plans with a prior authorization requirement by calculating the proportion of enrollees in plans that required prior authorization for the medication within each channel.
Finally, we measured the percentage of enrollees in plans with a step therapy requirement by calculating the proportion of enrollees in plans that imposed step therapy requirements for the medication in each channel.
These estimates, derived from national MMIT coverage data, provide insight into health insurance coverage for each medication. They take into account restrictions such as prior authorization, step therapy, and quantity limits. The percentages are expressed relative to the total number of enrollees covered by various insurance channels, including ACA plans, commercial (excluding ACA) plans, Medicare, and Medicaid (both state-run and managed care plans).
References
[Please keep the automatic spacing in between references. See Style Guide section on reference formatting.]
Healthcare.gov. (n.d.). Appealing a health plan decision: Internal appeals.
Mayne Pharma Commercial. (2025). Twyneo - benzoyl peroxide and tretinoin cream [package insert].
Medicaid.gov. (n.d.). Managed care.
Medicare.org. (2025). Does Medicare cover dermatology?
Twyneo. (n.d.). Savings & support. Mayne Pharma Commercial.
Twyneo. (2025). Mayne Pharma copay savings card letter. Mayne Pharma Commercial.
