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Truseltiq

infigratinib
Used for Liver Cancer
Used for Liver Cancer

Truseltiq (infigratinib) is used to treat bile duct cancer (cholangiocarcinoma) in adults. It was approved by the FDA in 2021 under accelerated approval based on its potential benefit in adults with previously treated bile duct cancer that can't be surgically removed. This medication has been discontinued and will no longer be available in the United States after March 2023.

Reviewed by:
reviewer
Kristianne Hannemann, PharmD
reviewer
Cydnee Ng, PharmD
Last reviewed on January 5, 2023
BasicsFAQsDosageCostReferencesPricesMedicare
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What is Truseltiq (infigratinib)?

What is Truseltiq (infigratinib) used for?

  • Bile duct cancer

How Truseltiq (infigratinib) works

Drug Facts

Common BrandsTruseltiq (brand name no longer available)
Drug ClassKinase inhibitor
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityDiscontinued
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faqs

Frequently asked questions about Truseltiq (infigratinib)

What is Truseltiq (infigratinib)?
Truseltiq (infigratinib) is a capsule that's taken by mouth used to treat certain types of bile duct cancer in adults who've already tried different therapies. This medication is a type of kinase inhibitor. It works by blocking signals in cancer cells that prevents them from growing and surviving. Truseltiq (infigratinib) was approved by the FDA based on an early clinical study showing that 23% of people who took Truseltiq (infigratinib) had a response to the medication. This means their cancer shrunk or disappeared after the treatment. Out of the people whose cancer responded to the medication, 32% of them maintained this response for 6 months or more.
Is Truseltiq (infigratinib) still available?
According to the manufacturer (Helsinn), Truseltiq (infigratinib) will be available until March 2023. After this time, the medication will no longer be available in the United States.
Why was Truseltiq (infigratinib) discontinued?
The manufacturer (Helsinn) states that Truseltiq (infigratinib) was discontinued because researchers couldn't get enough people with bile duct cancer to participate in their clinical studies. The purpose of the studies was to confirm the medication's clinical benefit — how well the cancer responded to Truseltiq (infigratinib) and how long this response lasted. When a medication is granted an accelerated approval, the FDA requires the manufacturer to confirm the medication's clinical benefit through studies at a later time for consideration for a traditional approval. Truseltiq (infigratinib) wasn't discontinued because of safety reasons or because the medication didn't work well. If you have questions, speak to your healthcare provider.
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dosage

Truseltiq (infigratinib) dosage forms

The average cost for 1 dose pack of 42 capsules of 125mg daily dose of Truseltiq (infigratinib) is $22225.80 with a free GoodRx coupon.0
dose pack
Dose pack
DosageQuantityPrice as low asPrice per unit
42 capsules of 50mg daily dose1 dose pack$22225.80$22225.80
63 capsules of 75mg daily dose1 dose pack$14821.20$14821.20
21 capsules of 100mg daily dose1 dose pack$22225.80$22225.80
42 capsules of 125mg daily dose1 dose pack$22225.80$22225.80
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Truseltiq (brand)
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References

Best studies we found

National Cancer Institute. (n.d.). Response rate.

National Cancer Institute. (2022). What is bile duct cancer (cholangiocarcinoma)?

Optum, Inc. (2022). Helsinn Therapeutics – Discontinuation of Truseltiq® (infigratinib).

View All References (4)

QED Therapeutics, Inc. (2021). Truseltiq (infigratinib) capsules, for oral use [package insert].

Subbiah, V., et al. (2023). Clinical development and management of adverse events associated with FGFR inhibitors. Cell Reports Medicine.

U.S. Food and Drug Administration. (2021). FDA grants accelerated approval to infigratinib for metastatic cholangiocarcinoma.

U.S. Food and Drug Administration. (2023). Accelerated approval.

GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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