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Troxyca ER

oxycodone / naltrexone
Used for Pain
Used for Pain

Oxycodone/naltrexone is a combination medication used to treat pain in people who require long-term pain treatment and when non-opioid medications don't provide enough relief. It contains an opioid painkiller that's released slowly throughout the day, and an additional medication called naltrexone that doesn't become active unless people try to abuse the medication by crushing it. Once this medication is crushed, naltrexone becomes active and blocks the oxycodone from working if it's used. Oxycodone/naltrexone has been discontinued and is no longer available in the United States.

Last reviewed on January 31, 2022
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What is Oxycodone/naltrexone?

How Oxycodone/naltrexone works

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Drug Facts

Common BrandsTroxyca ER
Drug ClassOpioid / Opioid antagonist
Controlled Substance ClassificationSchedule II
Generic StatusNo lower-cost generic available
AvailabilityDiscontinued
faqs

Frequently asked questions about Oxycodone/naltrexone

What is oxycodone/naltrexone?
Oxycodone/naltrexone is a combination medication made of two medications. Oxycodone is an opioid pain reliever that binds to certain parts of your brain, called mu-opioid receptors, to change how you react to pain. This helps lower how much pain you feel. Naltrexone is an opioid antagonist. It blocks the opioid receptors in your body and prevents you from feeling the effects of opioid medications (e.g., oxycodone). In this combination medication, the purpose of naltrexone is to prevent abuse (when a medication is used for non-medical reasons to bring out desirable physical or emotional effects). It's not active and won't work unless the tablet is crushed, such as in cases of abuse. If crushed, the naltrexone is released and will block the oxycodone from working in your body. For people abusing opioids regularly, this can cause bothersome withdrawal symptoms, such as changes in behavior or mood, chills, muscle aches, restlessness, and yawning.
Is oxycodone/naltrexone still available?
No. Oxycodone/naltrexone has been discontinued and is no longer available in the United States.
Why was oxycodone/naltrexone discontinued?
It's unclear why oxycodone/naltrexone was discontinued, but it's likely not due to safety reasons. There are many other abuse-deterrent opioid medications still available, and the manufacturer (Pfizer) likely made a business decision to stop making oxycodone/naltrexone.
Are there similar abuse-deterrent opioid pain relievers available?
Yes. There are other opioid medications available that are made with abuse-deterrent properties (e.g., tablets that form a thick gel when crushed and mixed for injection into a vein). Some examples are Xtampza ER (oxycodone ER) and Hysingla ER (hydrocodone ER). Speak to your provider about the best pain treatment options for you.
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