Oxycodone/naltrexone is a combination medication used to treat pain in people who require long-term pain treatment and when non-opioid medications don't provide enough relief. It contains an opioid painkiller that's released slowly throughout the day, and an additional medication called naltrexone that doesn't become active unless people try to abuse the medication by crushing it. Once this medication is crushed, naltrexone becomes active and blocks the oxycodone from working if it's used. Oxycodone/naltrexone has been discontinued and is no longer available in the United States.
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