The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Sleepiness
- Dry mouth
- Uncontrolled body movements
- Slowed movements
- Restlessness
- Tremors
- High blood pressure
Less Common Side Effects
- Headache
- Dizziness
- Weakness
- Nausea
- Vomiting
- Constipation
- Sweating
- Itching
- Skin rash
- Swelling in legs
- Hair loss
- Blurred vision
- Irregular heartbeat
- Low blood pressure (particularly when standing from sitting or lying down)
- Trouble urinating
- Changes in weight
Perphenazine/Amitriptyline serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Suicidal thoughts and behaviors
- Tardive dyskinesia (TD): uncontrollable movements like lip smacking, eye blinking, sticking out your tongue, or grimacing
- Neuroleptic malignant syndrome (NMS): high fever, fast heart rate, full body stiffness, confusion
- Heart problems: heart attack, irregular heartbeat
- Stroke: sudden numbness, weakness, confusion, or difficulty talking
- Seizure
Source: DailyMed
The following Perphenazine/Amitriptyline side effects have also been reported
Along with its needed effects, perphenazine (included in this combination medicine) can sometimes cause serious side effects. Tardive dyskinesia (a movement disorder) may occur and may not go away after you stop using the medicine. Signs of tardive dyskinesia include fine, worm-like movements of the tongue, or other uncontrolled movements of the mouth, tongue, cheeks, jaw, or arms and legs. Other serious but rare side effects may also occur. These include severe muscle stiffness, fever, unusual tiredness or weakness, fast heartbeat, difficult breathing, increased sweating, loss of bladder control, and seizures (neuroleptic malignant syndrome). You and your doctor should discuss the good this medicine will do as well as the risks of taking it.
Stop taking this medicine and get emergency help immediately if any of the following effects occur:
Rare
Convulsions (seizures)
difficulty in breathing
fast heartbeat
high or low blood pressure
increased sweating
loss of bladder control
muscle stiffness (severe)
unusual tiredness or weakness
unusually pale skin
Check with your doctor as soon as possible if any of the following side effects occur:
More common
Blurred vision or any change in vision
difficulty in speaking or swallowing
fainting
inability to move eyes
lip smacking or puckering
loss of balance control
mask-like face
muscle spasms, especially of face, neck, and back
nervousness, restlessness, or need to keep moving
puffing of cheeks
rapid or fine, worm-like movements of tongue
shuffling walk
stiffness of arms and legs
trembling and shaking of fingers and hands
tic-like or twitching movements
twisting movements of body
uncontrolled chewing movements
uncontrolled movements of arms or legs
weakness of arms and legs
Less common
Confusion
difficult urination
hallucinations (seeing, hearing, or feeling things that are not there)
increased skin sensitivity to sun
shakiness
slow pulse or irregular heartbeat
Rare
Abdominal or stomach pain
aching muscles or joints
back or leg pain
fever and chills
hot, dry skin or lack of sweating
irritability
loss of appetite
muscle weakness or twitching
nosebleeds
prolonged, painful, inappropriate penile erection
ringing, buzzing, or other unexplained noises in ears
skin rash and itching
sore throat and fever
swelling of face and tongue
swelling of testicles
unusual bleeding or bruising
yellow eyes or skin
Symptoms of overdose
Agitation
confusion
convulsions (seizures)
drowsiness (severe)
enlarged pupils
fast, slow, or irregular heartbeat
hallucinations (seeing, hearing, or feeling things that are not there)
shortness of breath or troubled breathing
unusual tiredness or weakness (severe)
vomiting (severe)
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Decreased sweating
dizziness
drowsiness
dryness of mouth
headache
increased appetite for sweets
tiredness or weakness (mild)
unpleasant taste
weight gain (unusual)
After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:
Dizziness
nausea or vomiting
stomach pain
trembling of fingers and hands
symptoms of tardive dyskinesia, including lip smacking or puckering, puffing of cheeks, rapid or fine, worm-like movements of tongue, uncontrolled chewing movements, or uncontrolled movements of arms or legs
After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:
headache
irritability
restlessness
trouble in sleeping, with vivid dreams
unusual excitement
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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