The average cost for 90 tablets of 2mg/25mg of Perphenazine/Amitriptyline is $62.37 with a free GoodRx coupon. This is 64.38% off the average retail price of $175.12.
Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
2mg/10mg | 90 tablets | $58.80 | $0.65 |
2mg/25mg | 90 tablets | $62.37 | $0.69 |
4mg/10mg | 60 tablets | $40.02 | $0.67 |
4mg/25mg | 30 tablets | $24.74 | $0.82 |
4mg/50mg | 30 tablets | $36.46 | $1.22 |
Typical dosage for Perphenazine/Amitriptyline
The dose depends on how old you are and how severe your symptoms of depression, anxiety, or schizophrenia are.
Starting dose
- Anxiety and depression: The usual starting dose is one tablet of 2 mg/25 mg or 4 mg/25 mg (perphenazine/amitriptyline) by mouth three or four times per day. You can also take the 4 mg/50 mg (perphenazine/amitriptyline) tablet by mouth twice per day.
- Severe schizophrenia with depressive symptoms: The usual starting dose is two tablets of 4 mg/25 mg (perphenazine/amitriptyline) by mouth three times per day. If needed, your prescriber might add another 4 mg/25 mg (perphenazine/amitriptyline) tablet to take at bedtime.
- People ages 65 years and older, adolescents, or people who have more anxiety than depression: The usual starting dose is one tablet of 4 mg/10 mg (perphenazine/amitriptyline) by mouth three or four times per day.
Maintenance dose
- After your symptoms get better, your prescriber might change your dose of Perphenazine/Amitriptyline so you're taking the lowest dose possible for your condition.
- A typical maintenance dose is one tablet of 2 mg/25 mg or 4 mg/25 mg (perphenazine/amitriptyline) by mouth two to four times per day. You can also take the 4 mg/50 mg (perphenazine/amitriptyline) tablet by mouth twice per day.
The maximum dose is 16 mg/200 mg (perphenazine/amitriptyline) per day.
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Reviewed by:
Robert Chad Hakim, PharmD, BCCCPRobert Chad Hakim, PharmD, BCCCP, started his full-time career as a clinical pharmacist at UCLA Health in the general medicine, general cardiology, and ICU units after completing residency in 2016. He also was the preceptor for the general medicine rotation from 2017 to 2021, which was a required rotation for all pharmacy residents.

Reviewed by:
Kristianne Hannemann, PharmDKristianne Hannemann, PharmD, is a licensed pharmacist in California. She has been a retail pharmacy manager and staff pharmacist for over 7 years and has contributed drug information content to different health companies.