Tri-Luma (Flucinolone/Hydroquinone/Tretinoin) is a combination corticosteroid, a retinoid similar to vitamin A, and a drug used to lighten the skin. It is used on the skin to treat melasma. Tri-Luma is the most popular melanin synthesis inhibitor/retinoid/corticosteroid combinations. There are currently no generic alternatives to Tri-Luma.
GoodRx has partnered with Inside Rx and Galderma Pharmaceuticals to reduce the price for this prescription. Check our savings tips for co-pay cards, assistance programs, and other ways to reduce your cost. Tri-Luma is covered by most Medicare and insurance plans.
Tri-Luma Side Effects
What should I watch for?
Improvement of the treated areas occurs gradually. It may take up to 8 weeks of treatment before the full effects of this medicine are seen. After stopping treatment, the melasma spots may darken again over time and return.
Excessive or prolonged application of this cream may cause the treated areas or surrounding skin to become temporarily lighter than your normal skin. Discontinue application of this medicine to any such affected areas.
If sensitivity or increased irritation occurs or if the melasma spots become darker with treatment, stop using this medicine and contact your doctor.
Do not get this medicine in the eyes, inside the nose, on wounds, or any other sensitive areas of skin. If it gets in your eyes, rinse thoroughly with water and contact your doctor or health care professional.
This medicine can make you more sensitive to the sun. Keep out of the sun. If you cannot avoid being in the sun, wear protective clothing and use sunscreen. Do not use sun lamps or tanning beds/booths.
Do not use this medicine if you are pregnant or trying to become pregnant. Ask your doctor or health care professional for effective birth control measures if you are a female and able to have children.
To reduce skin dryness you may use a moisturizer in the morning after you wash your face.
Do not use the following products on the same areas that you are treating with this medicine, unless directed by your doctor or health care professional: other topical agents with a strong skin drying effect such as products with a high alcohol content, astringents, spices, the peel of lime or other citrus, medicated soaps or shampoos, permanent wave solutions, electrolysis, hair removers or waxes, or any other preparations or processes that might dry or irritate your skin. Ask your doctor or health care professional before using these products.
Common and Rare Side Effects
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
Redness, peeling, drying, itching, or burning of the skin
Darkening of normal skin color
Incidence not known
Blistering, crusting, or flaking of the skin
burning and itching of the skin with pinhead-sized red blisters
lightening of normal skin color
redness and scaling around the mouth
severe redness, soreness, or scaling of the skin
thinning of the skin with easy bruising
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.