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Tri Luma

Tri-Luma Side Effects

Allison Gourley, PharmDKristianne Hannemann, PharmD
Reviewed by Allison Gourley, PharmD, Kristianne Hannemann, PharmD
Last reviewed on July 13, 2026

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Skin redness (41%)
  • Skin peeling or flaking (38%)
  • Burning feeling on the skin (18%)
  • Dry skin (14%)
  • Itchy skin (11%)

Less Common Side Effects

  • Acne
  • Skin irritation
  • Spider veins
  • Extra sensitive skin
  • Numb feeling on the skin
  • Changes to the color of your skin

Tri-Luma serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Allergic reaction: swelling of your face, eyes, lips, tongue, or throat; trouble breathing; severe itching; skin rash; hives
  • Severe skin reaction: severe burning, swelling, or skin irritation
When do Tri-Luma possible side effects begin and end?
Time passed since treatment started:
H
D
W
M
Brief skin reaction (redness, burning, itching)
Dry skin
Brief skin peeling

Source: DailyMed

The following Tri-Luma side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Redness, peeling, drying, itching, or burning of the skin

Less common

Darkening of normal skin color

irritated skin

rash

Incidence not known

Blistering, crusting, or flaking of the skin

burning and itching of the skin with pinhead-sized red blisters

lightening of normal skin color

redness and scaling around the mouth

severe redness, soreness, or scaling of the skin

thinning of the skin with easy bruising

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Blemishes on the skin

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

pimples

raised, dark red, wart-like spots on the skin

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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