The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Feeling thirsty (16%)
- Dry mouth (13%)
- Urinating more often and more volume (11%)
- Lack of energy (9%)
- Constipation (7%)
- High blood sugar (6%)
Less Common Side Effects
- Fever
- Poor appetite
Tolvaptan (Samsca) serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Osmotic demyelination syndrome: confusion, problems swallowing, slurred speech, low energy, weakness in face, arms, or legs
- Liver problems or liver failure: yellowing of your skin or the whites of your eyes, confusion, fatigue, poor appetite, nausea, stomach discomfort, vomiting
- Losing too much body fluid: dry mouth, dry skin, fast heart rate, dizziness, lightheadedness, feeling tired
- High blood potassium levels: tiredness, muscle weakness, tingling or numbness, irregular heartbeat, trouble breathing
Source: DailyMed
The following Tolvaptan (Samsca) side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
More common
Blurred vision
flushed, dry skin
fruit-like breath odor
increased hunger
increased thirst
increased urination
increased volume of pale, dilute urine
stomach pain
sweating
thirst
troubled breathing
unexplained weight loss
unusual tiredness or weakness
vomiting
Less common
blood in the urine
bloody stools
blue lips, fingernails, or skin
bruising
confusion
coughing or vomiting blood
dark urine
dizziness or lightheadedness
fainting
fast, slow, irregular, or shallow heartbeat
irregular, fast or slow, or shallow breathing
loss of consciousness
muscle cramp, spasm, pain, or stiffness
pain, redness, or swelling in the arm or leg
persistent bleeding or oozing from puncture sites, mouth, or nose
pink or red urine
rash
rectal bleeding
stomach tenderness
troubled breathing
sweating
vaginal bleeding
Incidence not known
Difficulty swallowing
general feeling of tiredness or weakness
headache
irritability
light-colored stools
muscle twitching
puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
restlessness
seizures
stomach pain, continuing
swelling of the feet or lower legs
tightness in the chest
yellow eyes or skin
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Difficulty having a bowel movement
lack or loss of strength
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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