bexarotene
Targretin (bexarotene) is a topical gel used to treat skin problems that happen with a rare type of cancer called cutaneous T-cell lymphoma. This cancer can affect the skin and cause red, scaly patches, and even tumors. Targretin (bexarotene) is usually for people who have tried other medications but need a treatment that works better.
What is Targretin (bexarotene)?
What is Targretin (bexarotene) used for?
- Cutaneous T-cell lymphoma (refractory or persistent)
How Targretin (bexarotene) works
Targretin (bexarotene) is a retinoid acid derivative. It stops cancer cells from growing and multiplying. However, the exact way in which the medication works to treat cutaneous T-cell lymphoma is not known.
Drug facts
Side effects of Targretin (bexarotene)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Rash (72%)
- Itching (36%)
- Pain (30%)
Less Common Side Effects
- Skin irritation
- Headache
- Swelling
- Infection
The following Targretin (bexarotene) side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Since this medication is given in varying doses, the actual frequency of side effects may vary. In general, side effects are less common with lower doses than with higher doses.
Check with your doctor as soon as possible if any of the following side effects occur:
More common
Unusual tiredness or weakness
skin rash or other skin and mucous membrane lesions
increase in lipid or cholesterol levels
coldness, dry, puffy skin or weight gain
chills, cough, hoarseness, lower back or side pain or painful or difficult urination
swelling of the arms, feet, hands, or legs
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
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Pros and cons of Targretin (bexarotene)
Pros
- Good option for people who didn't see benefits from other medications
- Has few interactions with oral medications because only a small amount gets absorbed into the body
- Not known to cause any severe or major side effects
Cons
- Can take 4 weeks or more before your symptoms get better
- Can make your skin more sensitive to light, so you need to limit sunbathing or tanning while using this medication
- Not a good choice if you're pregnant or planning on becoming pregnant because it can cause harm to the unborn baby
- Only available as brand-name medication, so can be expensive
Pharmacist tips for Targretin (bexarotene)
- If you're able to become pregnant, take a pregnancy test within 1 week before starting Targretin (bexarotene) and also monthly while you're using the medication. It's important to make sure you're not pregnant while taking this medication, because it can cause harm to an unborn baby.
- If you're a female of childbearing age, use two methods of reliable birth control 1 month before starting, during treatment, and for 1 more month after stopping Targretin (bexarotene). If you're a male taking Targretin (bexarotene) and your partner is able to become pregnant, you'll also need to take measures to prevent pregnancy while taking this medication (e.g., use a condom). Discuss with your provider about what precautions to take and which birth control methods to use.
- Apply a generous amount of Targretin (bexarotene) to the areas of lesions only. Avoid getting Targretin (bexarotene) on any healthy skin or on or near your eyes, nose, mouth, or genitals to lower the chances of irritation.
- Targretin (bexarotene) takes time to start working and can take almost a year before you start seeing improvement. Remember to be patient and continue using the medication as instructed by your provider.
- Wait at least 20 minutes to apply Targretin (bexarotene) after a bath or shower. Let the medication dry completely before covering your skin with clothing. It's best to wait at least 3 hours before showering, bathing, or swimming if you've already applied Targretin (bexarotene) to your skin.
- Be careful not to expose your skin to the sun too much or use tanning lamps while using Targretin (bexarotene). The medication makes your skin more sensitive to light and raises your risk of skin irritation.
- Don't use other products, especially ones containing DEET, on the same areas of the skin where you apply Targretin (bexarotene).
- If you're also taking vitamin A supplements, be sure to check with your healthcare provider first because it can cause unwanted side effects.
Common questions about Targretin (bexarotene)
Yes, Targretin (bexarotene) is considered chemotherapy because it can slow the growth of cancer cells in your body.
You might notice improvement after 4 weeks of using Targretin (bexarotene). But for most people, it usually takes longer for it to start working. If you see any improvements, make sure to keep using the medication as instructed by your provider so it continues to control your symptoms.
No, don't use any dressings along with Targretin (bexarotene). Wait for it to dry completely before covering your skin with clothing.
Targretin (bexarotene) gel is only available as a brand medication, so it can be expensive. However, there is a pill form that's available as a generic. Check with your provider to see which medication is best for you.
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Risks and warnings for Targretin (bexarotene)
Targretin (bexarotene) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Harm to unborn baby
- Risk factors: Sexually active women and men of childbearing age
Targretin (bexarotene) can harm an unborn baby during pregnancy, so don't take it if you're pregnant. If you're a female of childbearing age, speak to your healthcare provider about birth control options. It's recommended to use two methods of birth control 1 month before starting, during treatment, and for 1 more month after stopping Targretin (bexarotene). Talk to your provider about using other medications to treat your condition if you're pregnant or planning to become pregnant. If you're a male taking Targretin (bexarotene) and your partner is able to become pregnant, discuss with your provider about the precautions you should take during treatment, such as using a condom during sex.
Targretin (bexarotene) dosage
Tube of gel| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 60g of 1% | 1 tube | $7,254.00 | $7,254.00 |
Typical dosage for Targretin (bexarotene)
For the first week, apply generously to the affected area(s) of your skin once every other day. Then, gradually apply more often as recommended by your provider, until you've reached a frequency that works to control your symptoms.
For example,
- Week 1: Apply once every other day.
- Week 2: Apply once daily.
- Week 3: Apply twice daily, and so forth.
Most individuals will see improvement of their symptoms by using the medication only twice a day.
Interactions between Targretin (bexarotene) and other drugs
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
- Chlortetracycline
- Demeclocycline
- Desogestrel
- Dienogest
- Doxycycline
- Drospirenone
- Efavirenz
- Eravacycline
- Estradiol
- Ethinyl Estradiol
- Ethynodiol
- Etonogestrel
- Gemfibrozil
- Gestodene
- Levonorgestrel
- Lymecycline
- Meclocycline
- Medroxyprogesterone
- Mestranol
- Methacycline
- Minocycline
- Nomegestrol
- Norelgestromin
- Norethindrone
- Norgestimate
- Norgestrel
- Omadacycline
- Oxytetracycline
- Paclitaxel
- Rolitetracycline
- Sarecycline
- Segesterone
- Tetracycline
- Tigecycline
- Ulipristal
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
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