Is Targiniq ER (oxycodone / naloxone) still available?

No, Targiniq ER (oxycodone / naloxone) has been [discontinued](https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=205777) and is no longer available in the United States. It's not clear why this medication has been discontinued.

What are other ways to lower pain in place of Targiniq ER (oxycodone / naloxone)?

There are some non-medication options to help with pain. These alternatives include physical therapy, massage, and [cognitive behavioral therapy](https://www.goodrx.com/health-topic/mental-health/cognitive-behavioral-therapy) (CBT). Ask your provider about [non-medication options or other pain medications](https://www.goodrx.com/conditions/pain/non-opioid-options-pain-relief-how-to-choose) that might be right for you.

Targiniq ER

Q: What is Targiniq ER (oxycodone / naloxone)?

Targiniq ER (oxycodone / naloxone) is made up of two medications. __[Oxycodone](https://www.goodrx.com/oxycodone/what-is)__ is an [opioid medication](https://www.goodrx.com/classes/opioids) that binds (attaches) to mu-opioid receptors in your brain to lower your response to pain. __[Naloxone](https://www.goodrx.com/naloxone/what-is)__ is an [opioid antagonist](https://www.goodrx.com/classes/opioid-antagonists) that blocks opioid receptors in your brain. The naloxone component is used to help [prevent medication abuse](https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6045950/#__sec11title). It blocks the pleasurable effects that occur when people abuse the medication through means other than swallowing it whole (e.g., self-injection, crushed tablet), but also causes [bothersome effects](https://www.ncbi.nlm.nih.gov/books/NBK526012/#_article-26222_s6_) when this is done.

oxycodone and naloxone

Used for Opioid Overdose

Targiniq ER (oxycodone / naloxone) is a combination medication used to treat pain when non-opioid medications don't provide enough relief. It's no longer available in the United States, because it was discontinued.

Reviewed by:

Robert Chad Hakim, PharmD, BCCCP

Cydnee Ng, PharmD

Last reviewed on July 13, 2022

Targiniq ER (oxycodone / naloxone) is a controlled substance, which means that it's more likely to be misused or cause dependence. There are federal and state laws that limit the amount of medication that can be prescribed or dispensed within a certain period of time.

What is Targiniq ER (oxycodone / naloxone)?

What is Targiniq ER (oxycodone / naloxone) used for?

Pain that isn't relieved by non-opioid medications

Drug facts

Common Brands	Targiniq ER(brand no longer available)
Drug Class	Opioid agonist / Opioid antagonist
Controlled Substance Classification	Schedule II
Generic Status	No lower-cost generic available
Availability	Discontinued

Common Brands

Targiniq ER(brand no longer available)

Drug Class

Opioid agonist / Opioid antagonist

Controlled Substance Classification

Schedule II

Generic Status

No lower-cost generic available

Availability

Discontinued

Common questions about Targiniq ER

Targiniq ER is made up of two medications. Oxycodone is an opioid medication that binds (attaches) to mu-opioid receptors in your brain to lower your response to pain. Naloxone is an opioid antagonist that blocks opioid receptors in your brain. The naloxone component is used to help prevent medication abuse. It blocks the pleasurable effects that occur when people abuse the medication through means other than swallowing it whole (e.g., self-injection, crushed tablet), but also causes bothersome effects when this is done.

No, Targiniq ER has been discontinued and is no longer available in the United States. It's not clear why this medication has been discontinued.

There are some non-medication options to help with pain. These alternatives include physical therapy, massage, and cognitive behavioral therapy (CBT). Ask your provider about non-medication options or other pain medications that might be right for you.

Targiniq ER

Targiniq ER (oxycodone / naloxone) is a controlled substance, which means that it's more likely to be misused or cause dependence. There are federal and state laws that limit the amount of medication that can be prescribed or dispensed within a certain period of time.

What is Targiniq ER (oxycodone / naloxone)?

What is Targiniq ER (oxycodone / naloxone) used for?

Drug facts

Common questions about Targiniq ER

Targiniq ER (oxycodone / naloxone) dosage

Typical dosage for Targiniq ER (oxycodone / naloxone)

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Common questions about Targiniq ER

Targiniq ER (oxycodone / naloxone) is a controlled substance, which means that it's more likely to be misused or cause dependence. There are federal and state laws that limit the amount of medication that can be prescribed or dispensed within a certain period of time.

What is Targiniq ER (oxycodone / naloxone)?

What is Targiniq ER (oxycodone / naloxone) used for?

Drug facts

Common questions about Targiniq ER

What is Targiniq ER?

Is Targiniq ER still available?

What are other ways to lower pain in place of Targiniq ER?

Targiniq ER (oxycodone / naloxone) dosage

Typical dosage for Targiniq ER (oxycodone / naloxone)

Common questions about Targiniq ER

What is Targiniq ER?

Is Targiniq ER still available?

What are other ways to lower pain in place of Targiniq ER?