Key takeaways:
Tagrisso (osimertinib) is a targeted therapy that treats certain types of lung cancer. The medication is generally distributed through specialty pharmacies.
Without insurance, 30 tablets of Tagrisso 80 mg cost about $ on average. But how much you actually pay will depend on several factors, including your location and insurance coverage status.
Most insurance plans cover Tagrisso, but many require prior authorization before approving coverage.
Save on related medications
If you’ve been diagnosed with lung cancer, there’s a good chance it’s non-small cell lung cancer (NSCLC). This is the most common type of lung cancer and has several treatment options, including medications that can help slow its growth.
One popular option is Tagrisso (osimertinib), a medication that targets certain mutations in NSCLC. It works by blocking changes called epidermal growth factor receptor (EGFR) mutations in cancer cells to help slow down their growth and spread. And it comes as 40 mg and 80 mg tablets.
There isn’t currently a lower-cost, generic version of Tagrisso available; it’s a brand-name medication that’s usually dispensed through specialty pharmacies. Tagrisso can cost several thousand dollars per month. But you may be able to reduce your costs by using insurance or looking into other savings opportunities.
How much does Tagrisso cost?
Without insurance, 30 tablets of Tagrisso 80 mg cost about $26014.24 on average. The same quantity of Tagrisso 40 mg costs an average of $17895.99. What you actually pay for the medication can depend on the pharmacy you choose, insurance coverage, and other factors.
What factors affect the cost of Tagrisso?
Several factors can affect how much you’ll pay for Tagrisso, including:
Location: Prescription medication prices can vary by city and region. For instance, GoodRx research shows that people located in places such as Denver and Atlanta usually pay less for prescriptions than those in New Orleans and Little Rock-Pine Bluff, Arkansas.
Pharmacy: Prices for Tagrisso can vary from one pharmacy to another.
Insurance: Most insurance plans cover Tagrisso, but prior authorization is often required. And you may still have some out-of-pocket costs, such as deductibles, copays, or coinsurance.
Discounts: You may be able to pay less for Tagrisso if you qualify for savings opportunities through the manufacturer.
Does insurance cover Tagrisso?
Tagrisso is widely covered by all insurance types, including commercial, Medicare, Medicaid and Affordable Care Act (ACA) marketplace plans. But most plans require prior authorization. This means your healthcare professional will likely have to get approval from your insurance company before it will cover the medication. Step therapy, which requires trying other lower-cost treatment options first, is rarely required.
Check your health plan’s formulary, or list of covered medications, to find out specific coverage details and costs. You can also contact your insurer directly if you have any questions.
How different insurance plans cover Tagrisso
The table below shows how widely various insurance types cover Tagrisso, plus whether prior authorization or step therapy is typically required.
Insurance type | Enrollees covered for Tagrisso 80 mg tablets | Enrollees required to get prior authorization | Enrollees required to do step therapy |
|---|---|---|---|
85.1% | 79.9% | 0.6% | |
Commercial plans (excluding ACA plans) | 99.6% | 72.9% | 0.5% |
Medicare (Medicare Advantage and Part D plans) | 100% | 96.7% | 0% |
Medicaid, including state-run and managed care plans | 99.9% | 45.8% | 5.5% |
Source: Managed Markets Insight & Technology, LLC™, as of September 11, 2025. (See methodology below.)
If Tagrisso isn’t covered by your plan, you can:
Ask your prescriber about other appropriate NSCLC medications that may be covered by your plan or have lower out-of-pocket costs.
Request a formulary exception for Tagrisso to see if your plan will cover it. Your prescriber can support the request with a letter of medical necessity that explains why Tagrisso is the right option for you.
Consider filing an appeal if your insurer denies the exception request.
Compare health insurance plans during open enrollment to see which ones offer the best coverage for Tagrisso and your other medications.
Enrolled in Medicare Part D? Here are some ways to save on your prescription medications.
How to use your flexible spending account (FSA) funds: You can spend FSA dollars on Tagrisso (osimertinib) and other eligible medical expenses before the deadline.
Wondering about side effects? While mild Tagrisso side effects can often be managed at home, here are some that may require prompt medical attention.
Ways to save on Tagrisso
Tagrisso can cost thousands of dollars per month if you’re paying out of pocket. But there are ways to reduce your expenses or even get the medication for free. Here are six ways to save on Tagrisso.
1. Apply for the manufacturer copay savings card
You may be able to pay as little as $0 per month with the Tagrisso Co-pay Savings Program if you meet the eligibility criteria. Although there are no income requirements, you must meet the following conditions:
Have commercial insurance that does not cover the full cost of Tagrisso
Live in the U.S. or Puerto Rico
Have a valid Tagrisso prescription
Not be enrolled in Medicaid, Medicare, or any other state-funded or federally funded prescription insurance program
2. See if you qualify for a patient assistance program
If you don’t qualify for the Tagrisso Co-pay Savings Program, you may still be able to get help through a patient assistance program. These programs are offered by pharmaceutical companies, nonprofits, and government agencies to help people who meet certain eligibility criteria get their medications at a low cost or for free.
For example, the AZ&Me Prescription Savings Program offers AstraZeneca medications at no cost to eligible individuals. You can apply for the program if you meet the following requirements:
Be uninsured or enrolled in Medicare Part B and/or Part D
Live in the U.S.
Have recently experienced a financial crisis
4. Ask for a 90-day supply
A 90-day supply of Tagrisso may be more cost-effective than filling a prescription every month. Some pharmacies offer cash discounts for larger fills, and some insurance plans will lower your copay if you switch to a 90-day fill. If you have insurance that covers Tagrisso, check whether your plan’s mail-order pharmacy also offers savings for a 90-day supply.
5. Compare prices at different pharmacies
Tagrisso is often filled through specialty pharmacies, and costs can vary. If you have insurance, contact your plan to confirm which specialty pharmacies are in the network. Filling your prescription through an in-network pharmacy can help you avoid higher costs and ensure you receive any plan discounts.
6. Consider using a tax-advantaged health account
If you have a tax-advantaged health account, you may be able to use those funds to help pay for Tagrisso and other qualified medical expenses. Health savings accounts (HSAs), flexible spending accounts (FSAs), and health reimbursement arrangements (HRAs) can all be used to pay for prescription medications.
Each type of account has different rules about contributions, spending, and deadlines, so make sure you understand how your account works to get the most value from it. Keep your receipts and documentation in case you need them for reimbursement or verification.
The bottom line
Without insurance or a GoodRx discount, 30 tablets of Tagrisso 80 mg cost about $26014.24 on average. But what you actually pay for the medication can depend on the pharmacy you choose, if you have insurance, and other factors.
If you have commercial insurance, you may be eligible for the Tagrisso Co-pay Savings Program, which can bring your costs down to $0 per monthly prescription fill. The manufacturer’s patient assistance program may offer the medication at no cost if you meet certain requirements, such as being uninsured or having recently experienced a financial crisis.
Why trust our experts?
Methodology
We obtained national prescription coverage data for each medication from Managed Markets Insight & Technology (MMIT). The data reflects health insurance coverage as of September 2025.
We calculated the percentage of enrollees in plans that cover each medication by dividing the number of enrollees covered for the medication within a specific insurance channel (e.g., ACA, Medicare, Medicaid) by the total number of enrollees in all plans within that channel.
We determined the percentage of enrollees in plans with a prior authorization requirement by calculating the proportion of enrollees in plans that required prior authorization for the medication within each channel.
Finally, we measured the percentage of enrollees in plans with a step therapy requirement by calculating the proportion of enrollees in plans that imposed step therapy requirements for the medication in each channel.
These estimates, derived from national MMIT coverage data, provide insight into health insurance coverage for each medication. They take into account restrictions such as prior authorization, step therapy, and quantity limits. The percentages are expressed relative to the total number of enrollees covered by various insurance channels, including ACA plans, commercial (excluding ACA) plans, Medicare, and Medicaid (both state-run and managed care plans).
References
American Lung Association. (2025). EGFR and lung cancer.
AstraZeneca. (n.d.). Affordability options may be available for Tagrisso.
AstraZeneca. (n.d.). AZ&Me Prescription Savings Program eligibility requirements.
AstraZeneca Pharmaceuticals. (2024). Tagrisso - osimertinib tablet, film coated [package insert]. DailyMed.
HealthCare.gov. (n.d.). Appealing a health plan decision.
Medicaid.gov. (n.d.). Managed care.
