Skip to main content
Synvisc

Synvisc Side Effects

Kristianne Hannemann, PharmDAllison Gourley, PharmD
Reviewed by Kristianne Hannemann, PharmD, Allison Gourley, PharmD
Last reviewed on November 6, 2024

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Synvisc:

  • Knee pain and swelling (7%)

Synvisc-One:

  • Joint pain (25%)
  • Joint stiffness (8%)
  • Joint swelling (up to 6%)

Less Common Side Effects

  • Rash
  • Itching
  • Muscle cramps or pain
  • Injection site pain
  • Trouble walking
  • Headache
  • Back pain

Synvisc serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Severe allergic reaction: hives, swelling in the face or throat, trouble breathing

Source: Prescribing Information

The following Synvisc side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

More common

Difficulty with moving

fluid build up around the knee

muscle pain or stiffness

pain and stiffness in the joints

Less common

Bleeding after defecation

bluish color

changes in skin color

fainting

fast, pounding, or irregular heartbeat or pulse

pain or aching in the lower legs

swelling of the ankles, feet, or legs

tenderness

uncomfortable swelling around the anus

warmth or swelling of the joints

Rare

Redness in the joints

Incidence not known

Black, tarry stools

bleeding gums

bloating or swelling of the face, arms, hands, lower legs, or feet

blood in the urine or stools

burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

chills

feeling of warmth

general feeling of discomfort or illness

muscle cramps

pinpoint red spots on the skin

rapid weight gain

redness of the face, neck, arms, and occasionally, upper chest

tingling of the hands or feet

trouble breathing

unusual bleeding or bruising

unusual tiredness or weakness

unusual weight gain or loss

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Itching of the skin

rash

sprain in the lower back

Rare

Pain at the injection site

Incidence not known

Dizziness

headache

nausea

raised red swellings on the skin, lips, tongue, or in the throat

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

GoodRx icon

Other Synvisc articles

Was this page helpful?