Synercid (quinupristin / dalfopristin) is an injectable, combination antibiotic that treats skin infections caused by certain bacteria. This medication works well against some resistant bacterial infections, or infections that are hard to get rid of even with the use of other antibiotics. But Synercid (quinupristin / dalfopristin) isn't commonly used today, because it can interact with a lot of other medications.
Synercid is approved for the treatment of complicated skin and soft tissue infections caused by certain Gram-positive bacteria. Additionally, the Infectious Diseases Society of America (IDSA) has suggested that Synercid may be an option for the treatment of certain infections in the brain that can't be treated with other antibiotics. Although it isn't FDA approved for this purpose, professional organizations like the IDSA have recommended it based on clinical evidence.
Synercid can treat skin infections caused by certain bacteria species called Staphylococcus aureus and Streptococcus pyogenes. It's also typically used for people who are confirmed to have a severe (or complicated) skin infection from resistant bacteria that will respond to Synercid or in people with allergies to penicillin antibiotics. Synercid isn't used often, because other newer antibiotics may have fewer interactions with medications and potentially lower cost than Synercid.
Synercid is a combination of two antibiotics. Quinupristin and dalfopristin both block the bacteria from making important proteins for growth and sustaining life. This causes the bacteria to be unable to survive.
Synercid is typically given as an injection through the veins (intravenously or IV) by a healthcare provider in the hospital. Each infusion takes about 1 hour.
The dose will depend on your body weight. The typical dose in adults and children 12 years or older is 7.5 mg/kg of body weight given through the veins (intravenously or IV) every 12 hours. The typical length of treatment for complicated skin and soft tissue infections is 7 days, but your provider might extend this to a longer period of time depending on how your infection is responding to the medication.
The most common side effects of Synercid include pain, inflammation, and swelling at the injection site. Less common side effects include nausea, vomiting, diarrhea, rash, itching, headache, and general pain.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are receiving this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.