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Synalgos DC
Synalgos DC is a combination medication that contains aspirin, caffeine, and dihydrocodeine. It's used to treat pain when non-opioid medications don't provide enough relief. Synalgos DC has been discontinued and is no longer available in the United States.
Last reviewed on January 24, 2022
Synalgos DC is a controlled substance, which means that it's more likely to be misused or cause dependence. There are federal and state laws that limit the amount of medication that can be prescribed or dispensed within a certain period of time.
What is Synalgos DC?
How Synalgos DC works
Are you looking for information on Trezix (acetaminophen / caffeine / dihydrocodeine) instead?
Drug Facts
Common BrandsSynalgos-DC (brand no longer available)
Drug ClassNSAID / Adenosine antagonist / Opioid
Controlled Substance ClassificationSchedule III
Generic StatusNo lower-cost generic available
AvailabilityDiscontinued
Frequently asked questions about Synalgos DC
What is Synalgos DC?
Synalgos DC is a combination of three medications that work together to relieve pain. Aspirin is a nonsteroidal anti-inflammatory drug (NSAID). It blocks a protein in your body that causes swelling and pain. Caffeine is an adenosine antagonist. It blocks the activity of a natural chemical in the body called adenosine. It's unclear how exactly caffeine works for pain, but it's thought to boost the activity of pain relievers. Dihydrocodeine is an opioid. It binds to certain parts of your brain, called mu-opioid receptors, and lowers how much pain you feel. Synalgos DC should only be taken if non-opioid medications don't provide enough pain relief, because there's a high risk of addiction, abuse, and misuse from dihydrocodeine (an opioid).
Is Synalgos DC still available?
No, Synalgos DC has been discontinued and is no longer available in the United States.
Why was Synalgos DC discontinued?
It's not clear why Synalgos DC was withdrawn from the market. If you've taken Synalgos DC previously and need to take this medication again, speak to your provider about alternatives.
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