Supprelin LA (histrelin) helps prevent early puberty in children 2 years of age and older. The medication works well to delay puberty, but it's an implant that is placed under your skin during a minor surgical procedure.
Precocious puberty (puberty that starts at an early age)
Supprelin LA (histrelin) is a hormone similar to one your body naturally makes called gonadotropin-releasing hormone (GnRH). It lowers reproductive hormone levels, estrogen and testosterone, which are a part of the process of puberty.
Source: FDA
Side effects that you should report to your care team as soon as possible:
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
Works well to prevent precocious puberty (early puberty)
Implanted once every 12 months
Well-tolerated with few side effects
Requires surgery to insert the implant, which can sometimes cause discomfort
Brand only, which makes it expensive
Implant can fall out if the wound doesn't heal properly
Supprelin LA (histrelin) is contained in an implant that needs to be placed surgically in the upper arm above the elbow. Follow your healthcare providers instructions to make sure the wound properly heals.
The child will require routine checkups of their condition to make sure that Supprelin LA (histrelin) is working properly. Certain hormones will be measured 1 month after implantation and then every 6 months after that.
After implantation, more signs and symptoms of early puberty can happen because of a rise in some hormones, but these will go away within 4 weeks of the implantation.
If your child experiences more crying, anger, restlessness (impatience) or irritability, let your healthcare provider know.
Supprelin LA (histrelin) might worsen emotional symptoms.
Supprelin LA (histrelin) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Supprelin LA (histrelin) is an artificial hormone similar to one your body makes, called gonadotropin-releasing hormone (GnRH). Supprelin LA (histrelin) can cause worsening of puberty symptoms when first started. These symptoms should go away within the first 4 weeks of therapy.
Supprelin LA (histrelin) is contained within an implant, which requires a surgical procedure to insert it and remove it. Talk to your healthcare provider about risks of the implant and the minor surgery.
People taking medications similar to GnRH, like Supprelin LA (histrelin), may have difficulty controlling emotions. Symptoms of emotional changes include crying, irritability, impatience, anger, and aggression (anger). As a parent, watch your child for changes in behaviors and emotions.
Risk factors: History of seizures | History of epilepsy | History of stroke | People taking certain medications including SSRIs or bupropion.
People taking medications similar to GnRH, like Supprelin LA (histrelin), may experience convulsions. If you experience tight muscles, uncontrollable movements, or painful cramping, call your healthcare provider right away.
This medication is a 50 mg implant that is placed under your skin during a minor surgical procedure once every 12 months. The implant is placed in the inside area of your upper arm above the elbow.
Precocious puberty (puberty that starts at an early age)
Precocious puberty (puberty that starts at an early age)
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