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Sodium Polystyrene Sulfonate

Sodium Polystyrene Sulfonate Side Effects

Robert Chad Hakim, PharmD, BCCCPAllison Gourley, PharmD
Reviewed by Robert Chad Hakim, PharmD, BCCCP, Allison Gourley, PharmD
Last reviewed on August 28, 2023

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Low appetite
  • Nausea
  • Vomiting
  • Constipation
  • Diarrhea

Less Common Side Effects

  • Gut irritations
  • Blockage in the gut

Sodium Polystyrene Sulfonate serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Intestinal necrosis (low blood flow to the stomach and intestines): bleeding in stool, nausea, vomiting, constipation or diarrhea, fever, stomach pain
  • Low electrolyte levels: muscle cramps, muscle pain, numbness or tingling, nausea, vomiting, weakness, shortness of breath, or confusion

Source: DailyMed

The following Sodium Polystyrene Sulfonate side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur:

Rare

Bloody vomit

chest pain

cough

cough producing mucus

difficulty with breathing

fever or chills

severe stomach pain

sneezing

sore throat

tightness in the chest

troubled breathing

Incidence not known

Confusion

constipation

decrease in the amount of urine

diarrhea

dry mouth

increased thirst

irregular heartbeat

loss of appetite

muscle cramps in the hands, arms, feet, legs, or face

nausea or vomiting

noisy, rattling breathing

numbness and tingling around the mouth, fingertips, or feet

seizures

severe constipation

swelling of the fingers, hands, feet, or lower legs

stomach cramps or pain

tremor

troubled breathing at rest

unusual tiredness or weakness

weight gain

weight loss

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Dizziness

drowsiness

fainting

fast, slow, or irregular heartbeat

lightheadedness

muscle spasms (tetany) or twitching

pounding or rapid pulse

trembling

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Robert Chad Hakim, PharmD, BCCCP, started his full-time career as a clinical pharmacist at UCLA Health in the general medicine, general cardiology, and ICU units after completing residency in 2016. He also was the preceptor for the general medicine rotation from 2017 to 2021, which was a required rotation for all pharmacy residents.
Allison Gourley, PharmD, is a kidney and pancreas transplant pharmacist at a teaching hospital in the San Francisco Bay Area. When she’s not educating patients about their immunosuppressants, she's actively involved in transplant research.

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