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Sodium Oxybate Coupon - Sodium Oxybate 180ml of 500mg/ml bottle of oral solution

sodium oxybate

Generic Xyrem
Used for Narcolepsy
Used for Narcolepsy

Sodium oxybate (Xyrem) is for people 7 years and older with narcolepsy. It's used to treat cataplexy (sudden muscle weakness after strong emotions) and excessive daytime sleepiness (EDS). This medication works as a central nervous system depressant. It's a liquid solution that you have to mix with water before you take it. The dosage is taken by mouth two times at night, once at bedtime, and then again 2.5 to 4 hours later. Side effects include nausea and dizziness. Some people, but especially children, might wet the bed. Sodium oxybate (Xyrem) is available with a prescription as a brand-name and generic medication.

Reviewed by:
reviewer
Allison Gourley, PharmD
reviewer
Cydnee Ng, PharmD
Last reviewed on September 2, 2025
BasicsWarningsSide effectsPros & consPharmacist tipsFAQsDosageInteractionsCostContraindicationsAlternativesLatest newsImagesReferencesPricesMedicare
Sodium oxybate (Xyrem) is a controlled substance, which means that it's more likely to be misused or cause dependence. There are federal and state laws that limit the amount of medication that can be prescribed or dispensed within a certain period of time.
basics-icon

What is Sodium oxybate (Xyrem)?

What is Sodium oxybate (Xyrem) used for?

How Sodium oxybate (Xyrem) works

Sodium oxybate (Xyrem) is a central nervous system (CNS) depressant. It's not entirely clear how the medication works. But researchers think that it affects proteins in the brain called gamma-aminobutyric acid (GABA) receptors. This might help with wakefulness for people with narcolepsy.

Are you looking for information on Lumryz (sodium oxybate) or Xywav (calcium oxybate / magnesium oxybate / potassium oxybate / sodium oxybate) instead?
When does Sodium oxybate (Xyrem) start working?
Time passed since treatment started:
HOURS
DAYS
WEEKS
MONTHS
Full effect

Drug Facts

Common BrandsXyrem
Drug ClassCNS depressant
Controlled Substance ClassificationSchedule III
Generic StatusLower-cost generic available
AvailabilityPrescription only

More on Sodium oxybate (Xyrem) essentials

narcolepsy: father and son at medical appointment 1372296514

Wakix vs. Xyrem for Narcolepsy in Children: 7 Differences to Consider

Written by Alex Evans, PharmD, MBA
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What are the risks and warnings for Sodium oxybate (Xyrem)?

Sodium oxybate (Xyrem) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.

risk-warning

Potential for misuse

  • Risk factors: Personal or family history of substance or alcohol use disorder | History of mental health problems | Taking more of sodium oxybate (Xyrem) than prescribed

    Sodium oxybate (Xyrem) is a controlled substance because it has a risk of misuse. Misuse can lead to serious, life-threatening problems. This can include seizure, extremely slowed breathing, and overdose. Misusing this medication can sometimes also lead to addiction. If you're worried about these risks, talk to your prescriber.

    risk-warning

    Changes in mental alertness

    • Risk factors: Drinking alcohol | Taking other CNS depressants

      Sodium oxybate (Xyrem) can slow down your brain. This can make you feel very sleepy and have trouble thinking, focusing, and reacting to things.

      Don't drive or do anything that needs your full attention until at least 6 hours after you take sodium oxybate (Xyrem). In general, it's also good idea to avoid these things until you know how this medication affects you.

      You can have changes in mental alertness at any time while taking sodium oxybate (Xyrem), even at recommended doses. Don't drink alcohol while taking this medication because it can raise your risk. Also don't take other CNS depressants, like opioids or other sedatives. Talk to your prescriber if you're worried about these risks.

      risk-warning

      Dangerously slowed breathing

      • Risk factors: History of breathing problems (e.g., sleep apnea) | Drinking alcohol | Taking other CNS depressants

        Sodium oxybate (Xyrem) can slow your breathing down to the point where it's very dangerous. This can look like shortness of breath and slow and shallow breathing. It can lead to bluish-colored lips, fingers, or toes. If slowed breathing isn't recognized and treated right away, it can be life-threatening. If you or a close one notices that your breathing is extremely slow, get medical help right away.

        Your breathing can slow down at any time while you're taking sodium oxybate (Xyrem). It can even become slow at recommended doses. But your risk is higher if you drink alcohol with sodium oxybate (Xyrem). It's also higher if you take other CNS depressants, like opioids and muscle relaxants. If you're worried about the risk of slowed breathing, speak to your prescriber.

        risk-warning

        Only available through the Xyrem REMS program

        Sodium oxybate (Xyrem) has a risk of misuse. It can also slow the body down and make your breathing extremely slow. Because of these risks, the FDA requires that sodium oxybate (Xyrem) can only be available through a Risk Evaluation and Mitigation Strategies (REMS) program. This safety program is called the Xyrem REMS program.

        Your prescriber will help you sign up for the Xyrem REMS program. Your prescriber and the pharmacy you get sodium oxybate (Xyrem) from must also enroll. This helps make sure you and everyone involved in your care understands the dangers of the medication.

        risk-warning

        Behavior changes, including depression and suicidal thoughts

        • Risk factors: History of mental health problems

          Some people who took sodium oxybate (Xyrem) had changes in behavior. This included confusion and anxiety. Some also felt paranoid, acted more aggressive, or saw or heard things that aren't there (hallucinations). Although rare, others reported having signs of depression or thoughts of hurting themselves.

          Let your prescriber know if you have a history of mental health problems. They might want to follow up with you more often. They can make sure your mental health is okay while you're taking sodium oxybate (Xyrem).

          Tell your prescriber if you start to behave in ways that aren't normal for you or have signs of depression while taking this medication. If you start thinking about wanting to hurt yourself, call 911 right away.

          risk-warning

          Unusual sleep behaviors (e.g., sleepwalking)

          Some people who took sodium oxybate (Xyrem) have sleepwalked or had other similar unusual sleep behaviors. This can look like having confused behavior or wandering throughout the night. These sleep behaviors can raise the risk of hurting yourself by accident.

          Make sure your family and loved ones know about this side effect so they can watch out for your safety. Tell your prescriber if you've sleepwalked or wandered around at night while taking sodium oxybate (Xyrem). Also let them know about any other strange things you've done while you're sleeping during treatment.

          risk-warning

          Contains a high amount of sodium

          • Risk factors: Heart failure | High blood pressure | Kidney problems

            Sodium oxybate (Xyrem) contains a high amount of sodium (salt). It can be dangerous to take for people who are sensitive to salt. This includes people with heart failure, high blood pressure, or kidney problems.

            Before starting sodium oxybate (Xyrem), tell your prescriber about your full medical history. They can make sure it's safe for you to take, given the high salt content in the medication.

            basics-icon

            What are the side effects of Sodium oxybate (Xyrem)?

            The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

            Common Side Effects

            Adults:
            • Nausea (up to 20%)
            • Dizziness (up to 15%)
            • Vomiting (up to 11%)
            • Sleepiness (up to 8%)
            • Bedwetting (up to 7%)
            • Tremor or shakiness (up to 5%)
            Children:
            • Nausea (20%)
            • Bedwetting (19%)
            • Vomiting (18%)
            • Headache (17%)
            • Weight loss (13%)
            • Poor appetite (9%)
            • Dizziness (8%)
            • Sleepwalking (6%)

            Other Side Effects

            Adults:
            • Stomach pain
            • Diarrhea
            • Dry mouth
            • Muscle spasms
            • Feeling "pins and needles"
            • Confusion about what's around you or time
            • Anxiety
            • Sleepwalking

            Serious Side Effects

            Contact your healthcare provider immediately if you experience any of the following.
            • Very slow breathing
            • Feeling overly sleepy
            • Fainting
            When do Sodium oxybate (Xyrem) possible side effects begin and end?
            Time passed since treatment started:
            MINUTES
            HOURS
            DAYS
            WEEKS
            MONTHS
            Sleepiness
            Trouble thinking or focusing
            Risk of very slowed breathing
            Seek immediate medical care if you experience this side effect.
            If a line continues to the right, you'll likely keep experiencing this side effect once it starts.

            Source: DailyMed

            The following side effects have also been reported

            Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

            Check with your doctor immediately if any of the following side effects occur:

            More common

            Bedwetting

            sleep walking

            Less common

            Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

            changes in behavior

            choking or gasping sounds

            daytime sleepiness or tiredness

            headache

            lack of appetite

            loud or frequent snoring

            rapid weight gain

            seeing, hearing, or feeling things that are not there

            thoughts of killing oneself

            trouble sleeping

            unusual weight gain or loss

            waking to urinate at night

            Incidence not known

            Being forgetful

            blurred vision

            decrease in the amount of urine

            dizziness

            fever

            hives, itching, skin rash

            hoarseness

            increase urge to urinate at night

            irritation

            joint pain, stiffness, or swelling

            nervousness

            noisy, rattling breathing

            pounding in the ears

            redness of the skin

            swelling of the face, fingers, hands, feet, or lower legs

            tightness in the chest

            trouble breathing or swallowing

            weight gain

            Get emergency help immediately if any of the following symptoms of overdose occur:

            Symptoms of overdose

            Agitation

            bluish lips or skin, not breathing

            chest pain or discomfort

            clumsiness

            confusional, agitated combative state

            drowsiness

            generalized slowing of mental and physical activity

            inability to hold bowel movement or urine

            increased sweating

            lightheadedness, dizziness, or fainting

            loss of consciousness

            muscle aches or weakness

            seizures

            shakiness and unsteady walk

            shivering

            slow or irregular heartbeat

            trembling or other problems with muscle control or coordination

            unusual tiredness or weakness

            weak or feeble pulse

            Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

            More common

            Diarrhea

            difficulty passing urine (dribbling)

            increased frequency, urgency, or burning on urination

            increased sweating

            nausea

            vomiting

            Less common

            Dry mouth

            Incidence not known

            Difficulty with moving

            Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

            Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

            pros-and-cons

            Pros and cons of Sodium oxybate (Xyrem)

            thumbs-up

            Pros

            A first-choice medication for narcolepsy

            Okay for children 7 years and older with narcolepsy to take

            Is a liquid mixture, so no need to swallow whole pills

            Dose can be adjusted if needed

            thumbs-down

            Cons

            Need to take two doses each night (one at bedtime, and another in the middle of the night)

            Need to mix the medication with water before taking

            Is a controlled substance, so there are special requirements to getting the medication filled

            Can't take with sedatives

            pharmacist-tips

            Pharmacist tips for Sodium oxybate (Xyrem)

            pharmacist

            • Take sodium oxybate (Xyrem) twice each night, both times at your bedside. Take the first dose at bedtime and then the second dose 2.5 to 4 hours later. It might be helpful to set an alarm to make sure you wake up for your second dose.

              • For each sodium oxybate (Xyrem) dose, you'll need to mix it with water before you take it. Don't take the medication without preparing it.

                • Sodium oxybate (Xyrem) can make you feel drowsy. It can also make it hard to think, pay attention, and react quickly. These problems can last for many hours after you take the medication. Don't drive or use machines until at least 6 hours have passed and you know how the medication affects you.

                  • Don't drink alcohol with sodium oxybate (Xyrem). It can raise your risk of serious side effects. This can include dangerously slowed breathing, loss of consciousness, coma, or even death. Talk to your prescriber if it's hard for you to stop drinking.

                    • When you're done using a sodium oxybate (Xyrem) bottle, pour any unused medication down the sink. You can throw away the empty bottle in the trash. Make sure to cross out your name or other personal information first.

                      How to prepare your sodium oxybate (Xyrem) dose:

                      • Keep unmixed sodium oxybate (Xyrem) in the bottle it came in until you're ready to take the medication. Keep the bottle out of reach of children and pets.

                        • Prepare your two sodium oxybate (Xyrem) doses of the night before bedtime. Follow the instructions on how to prepare the medication. If you have any questions, ask your prescriber or pharmacist.

                          • To prepare: Keep the bottle upright and use the syringe that comes with the medication to draw up your first dose of the night. Empty all the medication from the syringe into one of the provided containers. Add about 60 mL (1/4 cup) of water to the container and then mix well. Then, close the container. Repeat the same steps for the second dose of the night.

                            • Take the prepared, mixed sodium oxybate (Xyrem) doses within 24 hours. If it's been more than 24 hours after you've mixed it, empty the container(s) in the sink.

                              • Keep any prepared sodium oxybate (Xyrem) doses in a safe place, away from children and pets, until taken or given.

                                How to take sodium oxybate (Xyrem):

                                • Take your first dose of the night at bedtime, at least 2 hours after eating. This helps your body absorb the medication as best as it can. Then, take your second dose of the night 2.5 to 4 hours later. Drink each dose while sitting in bed.

                                  • Right after you take sodium oxybate (Xyrem), lie down in bed and stay in bed. The medication can make you fall asleep within 5 to 15 minutes. So taking it at bedside and getting into bed right after can help prevent you from falling and getting hurt.

                                    • If you forget to take your second dose of sodium oxybate (Xyrem) of the night, skip the missed dose. Wait until the next night to take your usual dose (once at bedtime and again 2.5 to 4 hours later).

                                      • Don't take your two nightly doses of sodium oxybate (Xyrem) at once. This can cause serious side effects.

                                        faqs

                                        Frequently asked questions about Sodium oxybate (Xyrem)

                                        Does sodium oxybate (Xyrem) cause weight gain or weight loss?
                                        Some people have said that they've lost some weight while taking sodium oxybate (Xyrem). It's not clear how much weight they lost, though. The medication can cause stomach upset or make you not want to eat as much as side effects. This could possibly lead to some weight loss. If you notice you're losing weight and you're worried about it, talk to your prescriber. If your child has weight changes, tell their prescriber because they might need to adjust the dose.
                                        What is the Xyrem REMS program?
                                        The Xyrem REMS program is an extra safety requirement for the medication from the FDA. It's required because the medication has a risk of misuse. It can also make you very sleepy, slow your breathing, and make it hard to think, focus, and react. These risks can be serious and dangerous. This Risk Evaluation and Mitigation Strategy (REMS) program makes sure that you and your care team understand these risks. Your prescriber will help you enroll in the Xyrem REMS program. Your prescriber and the pharmacy where you're getting the medication from will also need to enroll. If you have more questions about the Xyrem REMS program, ask your prescriber.
                                        Is sodium oxybate (Xyrem) a controlled substance?
                                        Yes. Sodium oxybate (Xyrem) is a schedule 3 controlled substance. This is because the medication has a risk of misuse. Misuse means taking the medication in a way other than how your prescriber told you to. Misuse can lead to very serious and possibly life-threatening problems. This can include dangerously slow breathing and overdose. It can also sometimes lead to addiction. Controlled substances like sodium oxybate (Xyrem) have federal and state laws about how they're prescribed and dispensed. Talk to your prescriber about these regulations and any questions you have. Also talk to them if you're worried about these risks with sodium oxybate (Xyrem).
                                        How long does it take for sodium oxybate (Xyrem) to work?
                                        It can take several weeks to see improvements in narcolepsy symptoms. In a study, adults had fewer cataplexy attacks after 4 weeks of taking sodium oxybate (Xyrem). In another study, adults had shorter episodes of excessive sleepiness during the day after about 8 weeks of treatment. Children also showed improvement after a few weeks of taking sodium oxybate (Xyrem). Note that some people were also taking other narcolepsy medications along with sodium oxybate (Xyrem) in these studies. Be sure to keep taking sodium oxybate (Xyrem) every night, even if you don't see any difference right away. This will help the medication work the best it can for you. If you have questions about how long sodium oxybate (Xyrem) is taking to work, talk to your prescriber.
                                        How much sodium is in sodium oxybate (Xyrem)?
                                        Sodium oxybate (Xyrem) contains a high amount of sodium (salt). The amount of sodium in the medication depends on your dose. For example, a total dose of 4.5 grams of medication each night contains 820 mg of sodium. And if an adult is taking 6 grams of medication each night, they're getting 1,100 mg of sodium per night. Tell your prescriber if you have a medical condition that makes you sensitive to sodium. This can include heart failure, high blood pressure, or kidney problems. Too much sodium in the body can be problematic for these people. Your prescriber can make sure you can take sodium oxybate (Xyrem) in a safe way. Or, they might suggest a different option for you.
                                        Can you take sodium oxybate (Xyrem) while pregnant?
                                        If you're pregnant or thinking about getting pregnant, talk to your prescriber. They can help you understand the risks and benefits of taking sodium oxybate (Xyrem). There isn't enough information to know if the medication is safe to take during pregnancy. In animal studies, sodium oxybate (Xyrem) harmed unborn babies when given during pregnancy. This included stillbirths and growth problems. Your prescriber can help you decide the safest option for you.
                                        What's the difference between Xyrem and Xywav?
                                        Xyrem and Xywav are both medications for people 7 years and older who have a sleep problem called narcolepsy. They both help with cataplexy and excessive daytime sleepiness related to this condition. But Xywav can also help adults with another sleep problem called idiopathic hypersomnia. What's more, Xyrem and Xywav both have sodium oxybate in it. But Xywav also has extra ingredients: calcium, potassium, and magnesium oxybates. And, the company that makes Xywav says that it has much less sodium per nightly dose than Xyrem, in fact 92% less. This might make Xywav a better option for people who need to limit salt for their health. Talk to your prescriber about how the two medications compare and see which one best fits your needs.
                                        What's the difference between Xyrem and Lumryz?
                                        Xyrem and Lumryz both have sodium oxybate in them. They're both used to treat cataplexy and excessive daytime sleepiness in people 7 years and older with narcolepsy. The main difference is how you take them. Xyrem is taken twice each night. You take it at bedtime and then again 2.5 to 4 hours later. But for Lumryz, you take it just once at bedtime. So, Lumryz might be a good option if you often miss your second dose of Xyrem of the night. Both need to be mixed with water before you take it. For Xyrem, you can take the medication as long as it's within 24 hours of mixing. But for Lumyrz, you have to take it within 30 minutes of mixing. Talk to your prescriber about how these medications compare and see which might be best for you.
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                                        dosage

                                        Sodium oxybate (Xyrem) dosage forms

                                        The average cost for 3 bottles of 180ml of 500mg/ml of Sodium oxybate (Xyrem) is $18968.27 with a free GoodRx coupon. This is 10.7% off the average retail price of $21239.97.
                                        bottle of oral solution
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                                        180ml of 500mg/ml3 bottles$18968.27$6322.76

                                        Typical dosing for Sodium oxybate (Xyrem)

                                        • Adults: The typical starting dose is 2.25 grams by mouth at bedtime, then 2.25 grams taken 2.5 to 4 hours later. Your prescriber will raise your dose every week to the recommended dose. The recommended dose is 6 to 9 grams by mouth per night, split evenly into two doses.

                                        • Children 7 years and older: Dosing will depend on your child's weight. The dose is taken at night, once at bedtime and again 2.5 to 4 hours later. Your child's prescriber will raise the dose about every week to the recommended dose.

                                        Your dose might differ if you have liver problems. It also might differ if you take divalproex (Depakote).

                                        interactions

                                        Interactions between Sodium oxybate (Xyrem) and other drugs

                                        Sodium oxybate (Xyrem) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Sodium oxybate (Xyrem). Please note that only the generic name of each medication is listed below.

                                        Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

                                        Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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                                        contraindications-icon

                                        Sodium oxybate (Xyrem) contraindications

                                        Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Sodium oxybate (Xyrem) will not be safe for you to take.
                                        alternatives

                                        What are alternatives to Sodium oxybate (Xyrem)?

                                        There are a number of medications that your doctor can prescribe in place of Sodium oxybate (Xyrem). Compare a few possible alternatives below.
                                        Sodium oxybate (Xyrem)
                                        Used for:
                                        $18968.27 Lowest GoodRx priceView Prices
                                        Wakix (pitolisant)
                                        Used for:
                                        View Prices
                                        images

                                        Sodium oxybate (Xyrem) images

                                        This medicine is Colorless Bottle Of Oral Solution.

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                                        References

                                        Best studies we found

                                        Hypersomnia Foundation. (n.d.). Glossary - cataplexy.

                                        Hypersomnia Foundation. (2024). Idiopathic hypersomnia.

                                        Jazz Pharmaceuticals. (n.d.). Xywav and Xyrem REMS.

                                        View All References (10)

                                        Jazz Pharmaceuticals. (2020). Jazz Pharmaceuticals announces U.S. FDA approval of Xywavâ„¢ (calcium, magnesium, potassium, and sodium oxybates) oral solution for cataplexy or excessive daytime sleepiness associated with narcolepsy. PRNewswire.

                                        Jazz Pharmaceuticals, Inc. (2025). Medication guide: Xyrem® (ZĪE-rem) (sodium oxybate) oral solution, CIII.

                                        Jazz Pharmaceuticals, Inc. (2025). Xyrem- sodium oxybate solution [package insert]. DailyMed.

                                        Maski, K., et al. (2021). Treatment of central disorders of hypersomnolence: An American Academy of Sleep Medicine clinical practice guideline. Journal of Clinical Sleep Medicine.

                                        MedlinePlus. (2025). Drug use and addiction.

                                        MedlinePlus. (2024). Succinic semialdehyde dehydrogenase deficiency.

                                        National Institute on Drug Abuse. (2011). Misuse of prescription drugs research report: Overview.

                                        National Sleep Foundation. (2020). Do I have excessive sleepiness?

                                        VanWert, A. L., et al. (2014). Sodium oxybate for narcolepsy: Explaining untoward effects and recommending new approaches in light of prevailing receptor pharmacology. Journal of Pharmacy Technology.

                                        U.S. Food and Drug Administration. (2016). FDA Drug Safety Communication: Warning against use of Xyrem (sodium oxybate) with alcohol or drugs causing respiratory depression.

                                        GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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