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Sodium Oxybate

Sodium Oxybate Side Effects

Allison Gourley, PharmDCydnee Ng, PharmD
Reviewed by Allison Gourley, PharmD, Cydnee Ng, PharmD
Last reviewed on September 2, 2025

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Adults:

  • Nausea (up to 20%)
  • Dizziness (up to 15%)
  • Vomiting (up to 11%)
  • Sleepiness (up to 8%)
  • Bedwetting (up to 7%)
  • Tremor or shakiness (up to 5%)

Children:

  • Nausea (20%)
  • Bedwetting (19%)
  • Vomiting (18%)
  • Headache (17%)
  • Weight loss (13%)
  • Poor appetite (9%)
  • Dizziness (8%)
  • Sleepwalking (6%)

Less Common Side Effects

Adults:

  • Stomach pain
  • Diarrhea
  • Dry mouth
  • Muscle spasms
  • Feeling "pins and needles"
  • Confusion about what's around you or time
  • Anxiety
  • Sleepwalking

Sodium Oxybate serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Very slow breathing
  • Feeling overly sleepy
  • Fainting
When do Sodium Oxybate possible side effects begin and end?
Time passed since treatment started:
M
H
D
W
M
Sleepiness
Trouble thinking or focusing
Risk of very slowed breathing
Seek immediate medical care if you experience this side effect.
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.

Source: DailyMed

The following Sodium Oxybate side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Bedwetting

sleep walking

Less common

Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

changes in behavior

choking or gasping sounds

daytime sleepiness or tiredness

headache

lack of appetite

loud or frequent snoring

rapid weight gain

seeing, hearing, or feeling things that are not there

thoughts of killing oneself

trouble sleeping

unusual weight gain or loss

waking to urinate at night

Incidence not known

Being forgetful

blurred vision

decrease in the amount of urine

dizziness

fever

hives, itching, skin rash

hoarseness

increase urge to urinate at night

irritation

joint pain, stiffness, or swelling

nervousness

noisy, rattling breathing

pounding in the ears

redness of the skin

swelling of the face, fingers, hands, feet, or lower legs

tightness in the chest

trouble breathing or swallowing

weight gain

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Agitation

bluish lips or skin, not breathing

chest pain or discomfort

clumsiness

confusional, agitated combative state

drowsiness

generalized slowing of mental and physical activity

inability to hold bowel movement or urine

increased sweating

lightheadedness, dizziness, or fainting

loss of consciousness

muscle aches or weakness

seizures

shakiness and unsteady walk

shivering

slow or irregular heartbeat

trembling or other problems with muscle control or coordination

unusual tiredness or weakness

weak or feeble pulse

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Diarrhea

difficulty passing urine (dribbling)

increased frequency, urgency, or burning on urination

increased sweating

nausea

vomiting

Less common

Dry mouth

Incidence not known

Difficulty with moving

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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