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Simcor

niacin and simvastatin
Used for High Cholesterol

Simcor (niacin / simvastatin) is a combination medication used to treat high cholesterol and triglycerides (fats). This medication has been discontinued and is no longer available in the United States.

Reviewed by:
reviewerSarah Lobello Pearson, PharmD
reviewerAllison Gourley, PharmD
Last reviewed on June 5, 2022
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What is Simcor (niacin / simvastatin)?

What is Simcor (niacin / simvastatin) used for?

  • High cholesterol
  • High triglycerides

Drug facts

Common Brands
Simcor(brand no longer available)
Drug ClassAntilipemic / Statin
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityDiscontinued
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Common questions about Simcor (niacin / simvastatin)

Simcor (niacin / simvastatin) is a combination of two medications: niacin extended release (ER) and simvastatin. Niacin works by affecting certain key pathways responsible for making cholesterol and triglycerides in the body. Simvastatin works by blocking cholesterol production in the liver. By working together, the two medications help lower low-density lipoprotein (LDL, or "bad" cholesterol) and triglycerides.

No, Simcor (niacin / simvastatin) has been discontinued and is no longer available in the United States.

Simcor (niacin / simvastatin) was discontinued because the FDA determined that adding niacin ER to simvastatin therapy didn't lower the risk of heart-related events (e.g., heart attack, stroke) any more than simvastatin alone. The manufacturer of the combination medication (AbbVie) then voluntarily withdrew it from the market.

Both of the active ingredients in Simcor (niacin / simvastatin) are still available as single-ingredient medications: simvastatin (Zocor) and niacin ER. These medications can be used to lower cholesterol and triglycerides. There are also many other medications available for lowering cholesterol. Talk to your provider about what the best treatment option might be for you.

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Simcor (niacin / simvastatin) dosage

Typical dosage for Simcor (niacin / simvastatin)

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Interactions between Simcor (niacin / simvastatin) and other drugs

Simcor (niacin / simvastatin) may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Simcor (niacin / simvastatin). Please note that only the generic name of each medication is listed below.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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What are alternatives to Simcor (niacin / simvastatin)?

There are a number of medications that your doctor can prescribe in place of Simcor (niacin / simvastatin). Compare a few possible alternatives below.
Simcor (niacin / simvastatin)
Used for:
  • High cholesterol
  • High triglycerides
View prices
Simvastatin (Zocor)
Used for:
$9.07Lowest GoodRx priceView prices
Niacin ER
Used for:
  • High cholesterol and high triglycerides
  • Lower risk of repeat heart attack in people with a history of heart attack and high cholesterol
  • Slow plaque buildup in the arteries of people with a history of coronary artery disease (CAD) and high cholesterol (as an add-on medication)
  • Severely high triglycerides in people who are at risk of pancreatitis (as an add-on medication)
$23.23Lowest GoodRx priceView prices

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