Prescription-strength selenium sulfide is a topical antiseborrheic. It's used to treat dandruff, tinea versicolor (a type of fungal infection), and seborrheic dermatitis of the scalp. It works by killing fungus that grows on the scalp and helping your body shed less dead skin cells. Prescription-strength selenium sulfide comes as shampoo (selenium sulfide 2.3% and 2.25%) lotion (selenium sulfide 2.5%). Side effects can include skin irritation, change of hair color, and greasy or dry hair and scalp.
Note: Selenium sulfide is also available over-the-counter as selenium sulfide 1% shampoo.
Seborrheic dermatitis of the scalp (condition that causes dry, scaly, red, and itchy skin)
Tinea versicolor (fungal skin infection that causes discolored patches or spots on the body)
Selenium sulfide works in two ways. It treats tinea versicolor by stops certain fungus from growing on and irritating the skin. In treats dandruff and seborrheic dermatitis of the scalp by slowing down the shedding of skin cells.
Source: DailyMed
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur:
Less common or rare
Skin irritation
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Unusual dryness or oiliness of hair or scalp
Less common
Increase in normal hair loss
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Typically treats tinea versicolor with a week of treatment
Only needs to be used twice a week to manage dandruff and seborrheic dermatitis
Available as a lotion and shampoo
Applied to the skin
Might discolor your hair
Can cause hair to appear greasy or dry
Might damage jewelry if this medication gets on it
Prescription-strength shampoo might not a good option for children
Take off your jewelry before using selenium sulfide. This medication might damage jewelry.
Don't apply selenium sulfide to broken skin or inflamed areas. Don't allow it to come into contact with your eyes, mouth, nose, or genitals. Applying selenium sulfide to these areas can cause your skin to become very irritated.
Selenium sulfide can cause discoloration of your hair. To lower the risk of this side effect, rinse your scalp and hair extremely well after each treatment.
Selenium sulfide can cause your hair and scalp to become dry or oily. If you experience these side effects, ask your dermatologist for recommendations on how to minimize the symptoms.
It's unknown if this product can harm an unborn baby. Therefore, it's not recommended to use selenium sulfide during pregnancy. Speak with your prescriber if you find out you're pregnant while using this medication.
Selenium sulfide can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Only use selenium sulfide on the skin or scalp. Don't let it come in contact with your eyes, mouth, nose, or genitals. You should also avoid applying it to broken skin or inflamed areas. Serious skin irritation can occur if applied to these areas. If an allergic reaction happens, you should stop using selenium sulfide and contact your prescriber.
Selenium sulfide hasn't been studied in pregnant females, and it isn't known whether it's safe for an unborn baby. Therefore, it's recommended you avoid using it during pregnancy. If you're pregnant or would like to become pregnant, speak with your healthcare team to discuss the safest option for you to treat your symptoms.
Selenium sulfide comes in both a shampoo and lotion. The 2.3% shampoo is only approved for adults, while the 2.25% shampoo can be used by people 12 years and older. The 2.5% lotion can be used by both adults and children.
Dandruff and seborrheic dermatitis of the scalp
2.25% and 2.3% shampoo: Shake the bottle well before using. Wet your hair, apply selenium sulfide onto the scalp and massage gently into a full lather, then rinse off thoroughly. Use twice a week for 2 weeks to control symptoms, then less frequently or as instructed by your prescriber to keep symptoms under control.
2.5% lotion: Shake the bottle well before using. Wet your hair and massage 1 to 2 teaspoonfuls of selenium sulfide onto the scalp. Allow the medication to remain on the scalp for 2 to 3 minutes, then rinse the scalp thoroughly and repeat. Use twice a week for the first 2 weeks to control symptoms, then less frequently or as instructed by your prescriber to keep symptoms under control.
Tinea versicolor (fungal skin infection)
2.25% and 2.3% shampoo: Shake the bottle well before using. Wet the skin, apply selenium sulfide to the affected area(s) and massage gently into a full lather. Allow selenium sulfide to remain on the skin for 10 minutes, then rinse off thoroughly. Do this once daily for 7 days or as instructed by your prescriber.
2.5% lotion: Shake the bottle well before using. Apply selenium sulfide to the affected area(s) and lather with a small amount of water. Allow selenium sulfide to remain on the skin for 10 minutes, then rinse off thoroughly. Do this once daily for 7 days or as instructed by your prescriber.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Seborrheic dermatitis of the scalp (condition that causes dry, scaly, red, and itchy skin)
Tinea versicolor (fungal skin infection that causes discolored patches or spots on the body)
Tinea versicolor (prescription product)
Dandruff (over-the-counter product)
Treatment of acne in people ages 12 years and older
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Padagis Israel Pharmaceuticals Ltd. (2021). Selenium sulfide lotion [package insert]. DailyMed.
Ranganathan, S., et al. (2010). Dandruff: The most commercially exploited skin disease. Indian Journal of Dermatology.
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