Key takeaways:
Without insurance, the average cost of two 140 mg Repatha autoinjectors is $738.31.
Your out-of-pocket cost for Repatha can vary based on your dosage, pharmacy, insurance coverage, and other factors.
Savings options, including manufacturer copay savings cards, coupons, and patient assistance programs, may help reduce the cost. GoodRx offers exclusive discounts on Repatha, regardless of insurance status.
Save on related medications
Repatha (evolocumab) is an injectable medication used to lower cholesterol and reduce the risk of serious cardiovascular problems in certain people. It’s administered as a subcutaneous (under-the-skin) injection, typically every 2 weeks or once monthly.
Before starting Repatha, it’s a good idea to understand how much it costs — especially if you don’t have insurance.
How much does Repatha cost without insurance?
Without insurance, the average cost of two 140 mg Repatha SureClick autoinjectors is $738.31. Most people use either a 140 mg dose every 2 weeks or a 420 mg dose once monthly.
The Repatha Pushtronex System — an on-body device previously used for the 420 mg dose — and the 140 mg prefilled syringes have been discontinued. The monthly dose is now given as three back-to-back injections using autoinjectors only. If you’ve been using the prefilled syringes, you’ll need to switch to the autoinjectors.
Which factors affect the cost of Repatha?
Several factors can influence how much you’ll pay for Repatha.
Brand vs. generic availability
Repatha is available only as a brand-name medication. It’s also a biologic, meaning it’s made using living systems, such as animal cells. Because biologics are complex, they can’t be copied exactly like traditional medications. Instead, similar versions called biosimilars may be developed and often cost less.
But there are no biosimilars for Repatha, which contributes to its higher price.
Dosage and quantity
Your Repatha dosage schedule can affect your total cost. Repatha is typically given as 140 mg every 2 weeks or 420 mg once monthly. In some cases, the 420 mg dose may be given every 2 weeks.
The 140 mg every-2-weeks regimen requires 2 autoinjectors per month. With the Pushtronex system discontinued, the 420 mg dose requires three back-to-back injections using autoinjectors. This can increase the number of devices needed per fill, which may raise your overall cost.
Location
Medication prices can vary by region. For example, according to GoodRx research, medications are typically more affordable in Denver than in Little Rock, Arkansas.
Pharmacy
Prices can also vary between pharmacies. Comparing prices at different locations with price-comparison tools like GoodRx may help you find a lower cost.
Insurance coverage
If you have insurance, your price for Repatha will depend on your plan’s formulary, or list of covered medications. Deductibles, copays, and coinsurances may apply. And some plans may require prior authorization or step therapy (trying other medication first) before covering Repatha.
What to do if Repatha isn’t covered by your insurance
If your insurance doesn’t cover Repatha, try these options:
See if you qualify for financial assistance. If you’re uninsured or your plan doesn’t cover Repatha, you may qualify for a patient assistance program based on income.
Request a coverage exception or appeal. Your prescriber can submit documentation explaining why Repatha is medically necessary for you. If your insurance doesn’t approve the request, you can file an appeal.
Ask your prescriber about alternatives. Other cholesterol-lowering medications may be more affordable or covered by your plan. More on this later.
Compare insurance plans during open enrollment. If possible, you can review other plans to find one that offers better coverage for Repatha.
Ways to save on Repatha
Without insurance, Repatha can cost hundreds of dollars. But there are several savings strategies that you can explore to help lower your cost. Here are six options to consider.
1. Use a GoodRx coupon
GoodRx offers exclusive discounts on Repatha, regardless of insurance status. With a free GoodRx coupon, you could pay as little as $239 for 2 autoinjectors at participating pharmacies.
To access this exclusive discount:
Go to the GoodRx website, or open the app and type “Repatha” into the search bar.
Select your dosage form (SureClick) and quantity.
Select your preferred pharmacy, and click “get coupon.”
Have your discount information sent to you via text or email, or print it. If you’re using the app, keep the discount ready on your phone’s screen, or save it to your digital wallet.
To avoid delays, tell the pharmacy as soon as possible that you have a GoodRx coupon. Waiting until the pickup window can take more time to reprocess.
2. See if you qualify for a copay savings card
If you have commercial insurance that covers Repatha, you may be eligible for the manufacturer copay savings card. With the card, you could pay as little as $25 for a 1-month supply for $50 for a 3-month supply. To qualify, you must:
Have commercial insurance that covers Repatha
Live in the U.S. or a U.S. territory
Have a valid prescription for Repatha
You can sign up online for the copay card by enrolling in the Amgen Support Plus program. Share the copay card information with your pharmacy to access the discount.
People who are uninsured, have commercial insurance that doesn’t cover Repatha, or have government-funded insurance (e.g., Medicare, Medicaid) aren’t eligible for the card.
3. Check if you’re eligible for a patient assistance program
If you don’t have insurance, you may be eligible to get Repatha for free through the manufacturer’s patient assistance program. To qualify, you must:
Have lived in the U.S. or a U.S. territory for at least 6 months
Meet income requirements
Have no insurance coverage
Have a valid prescription for Repatha
You can apply online or download an application to be mailed or faxed. Call 1-800-932-3060 if you have questions or need assistance.
4. Ask about 90-day supplies
If you’re responding well to Repatha, you could get 90-day supplies instead of monthly fills. You’ll have fewer trips to the pharmacy and potentially lower out-of-pocket costs. Plus, some insurance plans offer discounted pricing on 90-day supplies at certain pharmacies. Talk to your pharmacy and insurer to see if this is an option for you.
5. Tap into your HSA, FSA, or HRA
You can use tax-advantaged funds from a health savings account (HSA), a flexible spending account (FSA), or a health reimbursement arrangement (HRA) to pay for Repatha. Keep in mind that FSA funds are good for only a certain period of time, while HSA funds roll over every year. HRA benefits may be carried over, depending on the employer. Be sure to keep your receipts to show proof of eligible expenses.
6. Ask your prescriber about lower-cost alternatives
Depending on why you’ve been prescribed Repatha, other cholesterol-lowering medications may be appropriate and more affordable. Most people start with a statin, which is available as a lower-cost generic. Medications like Repatha are often added when statins aren’t effective enough or well tolerated.
There are other nonstatin options your prescriber may consider. This will depend on your health needs and treatment goals.
The bottom line
Repatha (evolocumab) is an injectable medication that helps lower cholesterol and reduces the risk of serious cardiovascular problems in certain people. Without insurance, the average cost of two 140 mg Repatha autoinjectors is $738.31.
Manufacturer copay cards and patient assistance programs can help lower the cost of Repatha if you’re eligible. GoodRx also offers exclusive discounts on Repatha, regardless of insurance status. Your healthcare team can help you navigate cost, coverage, and ways to save.
Why trust our experts?


References
Amgen. (n.d.). Important information: Discontinuation of the Repatha prefilled single-dose syringe.
Amgen. (n.d.). Repatha Pushronex system (on-body-infusor with prefilled cartridge) discontinuation.
Amgen Safety Net Foundation. (n.d.). Eligibility.
Amgen USA. (2026). Repatha- evolocumab injection, solution. Repatha- evolocumab kit. DailyMed.
Biologic Licensing Application. (2026).
Repatha (evolocumab). (n.d.). Get helpful resources with Amgen SupportPlus. Amgen.
Repatha (evolocumab). (n.d.). Repatha (evolocumab) co-pay card terms & conditions. Amgen.



