The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Dark stools (16%)
- Nausea (8%)
- Diarrhea (7%)
- Headache (5%)
- Abdominal pain (5%)
- Change in taste (4%)
- Indigestion (3%)
- Weakness (3%)
- Vaginal infection (3%)
- Dizziness (3%)
Less Common Side Effects
- Constipation
- Dry mouth
- Higher liver enzymes
- Changes in urine
- Rash
- Itchy skin
- Anxiety
- Higher appetite
- Weight gain
Pylera serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Serious allergic reaction or skin reaction: hives, rash, blisters, skin peeling, skin reddening, fever, swelling of the lips or tongue, trouble breathing
- Brain and nerve problems: seizures, numbness in the feet and hands, pain when moving the eye, headache, dizziness, vertigo, coordination problems, slurred speech, easily irritable, depression, weakness, trouble sleeping
- High pressure around the brain: headache, dizziness, blurred vision, vision changes, blind spots
- Infectious diarrhea (C. difficile-related diarrhea):: loose and watery stools, severe stomach pain or cramps, fever, nausea
When do Pylera possible side effects begin and end?
Time passed since treatment started:
H
D
W
M
Dark stools
Nausea
Diarrhea
Stomach pain
Source: DailyMed
The following Pylera side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Increased pressure around the brain—severe headache, blurry vision, change in vision, nausea, vomiting
- Pain, tingling, or numbness in the hands or feet, muscle weakness, change in vision, confusion or trouble speaking, loss of balance or coordination, trouble walking, seizures
- Rash, fever, and swollen lymph nodes
- Redness, blistering, peeling, or loosening of the skin, including inside the mouth
- Seizures
- Severe diarrhea, fever
- Unusual vaginal discharge, itching, or odor
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):

