Prevduo

During major surgery, it's common to receive non-depolarizing neuromuscular blockers (NMBAs) to temporarily paralyze your muscles. After the surgery, you might be given Prevduo (neostigmine / glycopyrrolate) to reverse the effects of the NMBA. [[EDITOR|DRUGDISPLAYNAME]] contains two components: neostigmine, which reverses the paralysis, and glycopyrrolate, which helps prevent certain side effects caused by neostigmine, such as low heart rate and excessive body secretions.

Prevduo (neostigmine / glycopyrrolate) is a combination of two medications, neostigmine and glycopyrrolate. During surgery, non-depolarizing neuromuscular blockers (NMBAs) are used to block a chemical called acetylcholine in your body. This leads to temporary muscle paralysis, which is important for a successful surgery. Neostigmine is an acetylcholinesterase inhibitor that raises the levels of acetylcholine to reverse the paralyzing effects of NMBAs. But raising the levels of acetylcholine can also cause side effects in many other parts of your body, like low heart rate or excessive body secretions. So glycopyrrolate is used to block the effects of acetylcholine in the rest of your body to prevent side effects from neostigmine.

Prevduo (neostigmine / glycopyrrolate) is given by a trained healthcare provider as a quick injection through the veins (intravenously, IV) over one minute. You won't feel the Prevduo (neostigmine / glycopyrrolate) being given to you because you'll still be asleep from the surgery.

The dose of Prevduo (neostigmine / glycopyrrolate) is different for everyone. It depends on why you need the medication, your age, and your weight. Your provider will also change your dose based on a nerve stimulation test. It tests how deeply your muscles are paralyzed by sending a small electric shock to your nerve to see if your muscle twitches.