Prevduo

Prevduo (neostigmine / glycopyrrolate) is a combination of two medications, neostigmine and glycopyrrolate. During surgery, non-depolarizing neuromuscular blockers (NMBAs) are used to block a chemical called acetylcholine in your body. This leads to temporary muscle paralysis, which is important for a successful surgery. Neostigmine is an acetylcholinesterase inhibitor that raises the levels of acetylcholine to reverse the paralyzing effects of NMBAs. But raising the levels of acetylcholine can also cause side effects in many other parts of your body, like low heart rate or excessive body secretions. So glycopyrrolate is used to block the effects of acetylcholine in the rest of your body to prevent side effects from neostigmine.

Prevduo (neostigmine / glycopyrrolate) is given by a trained healthcare provider as a quick injection through the veins (intravenously, IV) over one minute. You won't feel the Prevduo (neostigmine / glycopyrrolate) being given to you because you'll still be asleep from the surgery.

The dose of Prevduo (neostigmine / glycopyrrolate) is different for everyone. It depends on why you need the medication, your age, and your weight. Your provider will also change your dose based on a nerve stimulation test. It tests how deeply your muscles are paralyzed by sending a small electric shock to your nerve to see if your muscle twitches.

Possible side effects from the neostigmine portion of Prevduo (neostigmine / glycopyrrolate) include low heart rate or blood pressure, difficulty sleeping, and itching. But the glycopyrrolate in Prevduo (neostigmine / glycopyrrolate) should help prevent or lessen these side effects. Side effects from glycopyrrolate in Prevduo (neostigmine / glycopyrrolate) include blurry vision, dry skin, dry mouth, and dizziness.