What is Plerixafor?
Commonly Used Brand Name(s)Mozobil
- Proper Use
- Before Using
- Breast Feeding
- Drug Interactions
- Other Interactions
- Other Medical Problems
Plerixafor injection is used together with a granulocyte-colony stimulating factor or G-CSF (eg, filgrastim, pegfilgrastim) to mobilize hematopoietic stem cells (HSC) for collection and transplantation in patients with non-Hodgkin's lymphoma (NHL) and multiple myeloma (MM).
This medicine is to be given only by or under the direct supervision of your doctor.
A nurse or other trained health professional may give you this medicine. It is given as a shot under your skin.
Plerixafor injection should be started after you have received a G-CSF medicine (eg, filgrastim, pegfilgrastim) for 4 days.
In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:
Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.
Appropriate studies have not been performed on the relationship of age to the effects of plerixafor injection in the pediatric population. Safety and efficacy have not been established.
Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of plerixafor injection in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require an adjustment in the dose for patients receiving plerixafor.
|All Trimesters||D||Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.|
There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. Tell your healthcare professional if you are taking any other prescription or nonprescription (over-the-counter [OTC]) medicine.
Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
Other Medical ProblemsTOP
The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:
- Bone marrow cancer or other bone marrow problems (eg, leukemia) or
- Enlarged spleen or
- Leukocytosis (high white blood cell count) or
- Thrombocytopenia (low blood platelet count)—Use with caution. May make these conditions worse.
- Kidney disease, moderate or severe—Use with caution. The effects may be increased because of slower removal of the medicine from the body.
It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood tests may be needed to check for unwanted effects.
Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If a pregnancy occurs while you are using this medicine, tell your doctor right away.
This medicine may enlarge your spleen, which could possibly burst. Check with your doctor right away if you are having a pain in the upper left part of your stomach or at the tip of your left shoulder.
Tell your doctor right away if you have slow heartbeat, severe, unusual tiredness or weakness, cold sweats, confusion, or dizziness, faintness, or lightheadedness when getting up from a lying or sitting position after you get the injection.
This medicine may cause a serious allergic reaction, called anaphylaxis, which can be life-threatening and requires immediate medical attention. Tell your doctor right away if you have a rash, itching, hoarseness, trouble breathing, trouble swallowing, or any swelling of your hands, face, or mouth after receiving this medicine.