The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Headache (9%)
- Constipation (5%)
Less Common Side Effects
- Diarrhea
- Dizziness
Palonosetron serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Allergic reactions: hives; trouble breathing; swelling of your face, lips, tongue, or throat
- Serotonin syndrome: fast heart rate, dizziness, sweating, flushing, tremor (shakiness), muscle stiffness or twitching, uncoordinated movement, distress, hallucinations
Source: DailyMed
The following Palonosetron side effects have also been reported
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor or nurse immediately if any of the following side effects occur:
Less common
Blurred vision
chest pain or discomfort
confusion
difficult breathing
dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
fainting
irregular heartbeats that continue
sweating
unusual tiredness or weakness
Rare
Bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
extra heartbeats
nervousness
pain in the shoulders, arms, jaw, or neck
pounding in the ears
slow or fast heartbeat
Incidence not known
Agitation
overactive reflexes
poor coordination
restlessness
shivering
talking or acting with excitement you cannot control
trembling or shaking
twitching
Get emergency help immediately if any of the following symptoms of overdose occur:
Symptoms of overdose
Bluish color of the fingernails, lips, skin, palms, or nail beds
collapse
gasping to breathe
paleness of the skin
seizures
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Difficulty having a bowel movement (stool)
headache
Less common
Acid or sour stomach
belching
bloated or full feeling
blood in the urine
bloody or black, tarry stools
burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
change in vision
chills
continuing ringing or buzzing
decrease in frequency of urination
decrease in urine volume
deep breathing
difficulty in passing urine
drowsiness
excess air or gas in the stomach or intestines
excessive sleeping
fear
feeling happy
feeling of warmth
flushed dry skin
fruit-like breath odor
general feeling of discomfort or illness
hearing loss
hiccups
impaired vision
increased hunger
increased thirst
increased urination
indigestion
joint pain
large, flat, blue or purplish patches in the skin
loss of appetite
muscle aches and pains
muscle tremors
numbness or tingling in the hands, feet, or lips
painful knees and ankles
passing gas
raised red swellings on the skin, the buttocks, legs or ankles
rash
red, sore eyes
redness of the face, neck, arms, and occasionally, upper chest
stomach discomfort, upset, or pain
sugar in the urine
swelling or protruding veins
trouble sleeping
unexplained noise in the ears
unexplained weight loss
unusually deep sleep
unusually long duration of sleep
vein discoloration
weakness or heaviness of the legs
Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.
Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.
Other Palonosetron articles
Other Serotonin Antagonists side effects articles
Why trust our experts?
