Appetite Stimulants: 9 Medications That Make You Want to Eat
Appetite stimulants like megestrol can help promote weight gain. People with certain health conditions may use appetite stimulants to meet nutritional needs.
oxandrolone
Used for Weight Gain
Used for Weight Gain
Oxandrolone is an oral tablet belonging to a class called anabolic steroids. It works to help build protein and muscle in adults and children after treatment with long-term steroids. It's also used to relieve osteoporosis-related bone pain. Oxandrolone is a schedule III controlled substance because it carries a risk of misuse, addiction, and dependence. Side effects include acne and swelling from too much fluid.
Note: Oxandrolone is no longer FDA-approved in the United States and therefore isn't available.
What is Oxandrolone?
What is Oxandrolone used for?
- Add-on treatment due to protein loss from long-term corticosteroid use
- Bone pain from osteoporosis
How Oxandrolone works
Oxandrolone is an anabolic steroid. It's a man-made version of testosterone, a hormone your body makes. By acting like testosterone, oxandrolone helps with weight and muscle growth as well as promote bone strength and health.
When does Oxandrolone start working?Time passed since treatment started:
Drug facts
| Common Brands | Oxandrin |
|---|---|
| Drug Class | Anabolic steroid |
| Controlled Substance Classification | Schedule III |
| Generic Status | No lower-cost generic available |
| Availability | Discontinued |
Risks and warnings for Oxandrolone
Oxandrolone can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Liver problems and tumors
Although rare, there have been reports of liver problems caused by blood-filled cysts or sacs (a problem called peliosis hepatis) in people taking anabolic steroids like oxandrolone. It's possible this condition can lead to liver failure or stomach bleeds. Liver tumors have also been seen in people taking this medication.
Depending on how long you're going to be taking oxandrolone, your provider might order blood tests to monitor your liver health regularly during treatment. Tell your provider if you have any signs of liver problems, such as yellowing of the skin, pale stool, and dark urine.
Risk of potential heart problems
Oxandrolone can
raise your "bad" cholesterol (LDL) and lower your "good" cholesterol (HDL). This raises your risk for severe heart problems like coronary artery disease. Your provider might measure your cholesterol levels during treatment with oxandrolone. Make sure to tell your provider if you have a history of high cholesterol or are taking medications for high cholesterol, such as statins or fibrates, before starting oxandrolone.
Swelling in the arms and legs
- Risk factors: History of heart, liver, or kidney problems | Taking other medications that cause swelling
Oxandrolone can cause your body to hang on to more fluid, which can cause swelling in the arms and legs. This can be especially serious in people who might be sensitive to changes in water weight, such as those with heart, liver, or kidney problems. Let your provider know if you notice any swelling in your arms and legs or start to gain weight quickly.
Stunted growth in children
- Risk factors: Younger age
Children taking oxandrolone might experience stunted growth, where their bones mature faster than they grow, leading to a failure to reach their full growth potential. This causes their adult height to be lower than it would've been had they not taken this medication. The younger the child, the greater the risk. Your child's healthcare provider will check your child's growth progress closely. If they suspect slowed or stunted growth, they might pause or stop your child's oxandrolone treatment.
Prostate problems
- Risk factors: Older adults
Older adults using anabolic steroids like oxandrolone are at a higher risk for developing an enlarged prostate (benign prostatic hyperplasia (BPH)) or prostate cancer. Let your provider know if you experience pain in the pelvic area, difficulty urinating, or blood in the urine.
Side effects of Oxandrolone
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Acne
- Trouble sleeping
- Swelling of the arms and legs
Males:
- Erection problems
- Irritated bladder
Females:
- Enlarged clitoris
- Changes to menstrual cycle
- Facial hair growth
- Male pattern baldness
Less Common Side Effects
- Changes in sex drive
- Depression
- Deepening of the voice
Oxandrolone serious side effects
Contact your healthcare provider immediately if you experience any of the following.
- Liver problems: severe nausea, vomiting, right-sided stomach pain, fatigue, low or no appetite, yellowing of the skin or eyes
When do Oxandrolone possible side effects begin and end?
Time passed since treatment started:
H
D
W
M
Trouble sleeping
Depression
If a line continues to the right, you'll likely keep experiencing this side effect once it starts.
The following Oxandrolone side effects have also been reported
Tumors of the liver, liver cancer, or peliosis hepatis, a form of liver disease, have occurred during long-term, high-dose therapy with anabolic steroids. Although these effects are rare, they can be very serious and may cause death. Discuss these possible effects with your doctor.
Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur:
For both females and males
Less common
Yellow eyes or skin
Rare (with long-term use)
Black, tarry, or light-colored stools
dark-colored urine
purple- or red-colored spots on body or inside the mouth or nose
sore throat and/or fever
vomiting of blood
Check with your doctor as soon as possible if any of the following side effects occur:
For both females and males
Less common
Bone pain
nausea or vomiting
sore tongue
swelling of feet or lower legs
unusual bleeding
unusual weight gain
Rare (with long-term use)
Abdominal or stomach pain
feeling of discomfort (continuing
headache (continuing)
loss of appetite (continuing)
unexplained weight loss
unpleasant breath odor (continuing)
Incidence not known
Lack or slowing of normal bone growth
For females only
For young males (boys) only
Less common
Unexplained darkening of skin
For sexually mature males only
More common
Enlargement of breasts or breast soreness
frequent or continuing erections
frequent urge to urinate
For elderly males only
Less common
>Difficult or frequent urination
Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
For both females and males
Less common
Chills
feeling of abdominal or stomach fullness
muscle cramps
trouble in sleeping
unusual decrease or increase in sexual desire
Pros and cons of Oxandrolone
Pros
- Dose is personalized for your body's response
- Oral tablet taken by mouth
Cons
- Risk for misuse, addiction, and dependence
- Can cause a serious liver condition that affects different parts of your body
Pharmacist tips for Oxandrolone
- Take oxandrolone with or without food.
- Mark your appointments in your calendar to see your provider and get any needed blood tests done while taking oxandrolone. Doing this will make sure the medication continues to work for you, and you're not having side effects.
- Take oxandrolone exactly as prescribed. Don't change your dose or suddenly stop taking the medication without talking to your provider first.
- Let your provider know if you're taking a blood thinner like warfarin (Coumadin) because oxandrolone can raise your risk for bleeding.
- Let your provider know if you're taking oral diabetes medications because oxandrolone might prevent them from being broken down in your body, which raises your risk for side effects like low blood sugar.
- Since oxandrolone is an anabolic steroid, females might notice changes like more facial hair, acne, or a deeper voice. Let your provider know if you're having any of these symptoms.
- Oxandrolone must be avoided in pregnancy due to the potential risk of severe harm to unborn babies. If you're pregnant or thinking of becoming pregnant, talk to your provider.
Oxandrolone dosage
Typical dosage for Oxandrolone
- Adults: The typical dose is 2.5 mg to 20 mg a day given by mouth, split into 2 to 4 doses throughout the day. The medication is usually taken for 2 to 4 weeks.
- Children: The typical dose is up to 0.1 mg/kg of body weight by mouth a day.
Your provider will adjust your dose of the medication based on how well it's helping your condition and if you're having side effects.
Interactions between Oxandrolone and other drugs
Oxandrolone may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Oxandrolone. Please note that only the generic name of each medication is listed below.
Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking any of these medicines, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.
Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.
Oxandrolone contraindications
Contraindications are specific health conditions or situations in which a person should not take a medication due to safety concerns. If you have any of the following conditions or if any of the following apply to you, let your healthcare provider know because Oxandrolone will not be safe for you to take.
- Prostate cancer or male breast cancer
- Female breast cancer with high calcium levels
- Pregnancy
- Nephrosis (a type of kidney disease)
- High calcium levels
News about Oxandrolone
