Omlonti
Omlonti (omidenepag isopropyl) is a relatively selective EP2 receptor agonist. It's an eye drop used to lower high pressure in the eyes caused by conditions like open-angle glaucoma or ocular hypertension. The eye drops are placed in the eye once per day in the evening. Side effects include eye redness and sensitivity to light. Omlonti (omidenepag isopropyl) was FDA approved in 2022.
What is Omlonti (omidenepag isopropyl)?
What is Omlonti (omidenepag isopropyl) used for?
Treatment of high pressure in the eye in adults with:
How Omlonti (omidenepag isopropyl) works
Omlonti (omidenepag isopropyl) is a relatively selective EP2 receptor agonist. The exact way it works isn't well-understood, but it's thought to lower pressure in the eye by helping fluids flow out of the eye.
Drug facts
Side effects of Omlonti (omidenepag isopropyl)
The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.
Common Side Effects
- Eye redness (9%)
- Eye sensitivity to light (5%)
Less Common Side Effects
- Dry eye
- Eye pain
- Eye inflammation (swelling)
- Eye irritation
- Blurry vision
- Other changes in vision
- Headache
The following Omlonti (omidenepag isopropyl) side effects have also been reported
Side effects that you should report to your care team as soon as possible:
- Allergic reactions—skin rash, itching, hives, swelling of the face, lips, tongue, or throat
- Change in vision
- New or worsening eye pain, redness, irritation, or discharge
Side effects that usually do not require medical attention (report these to your care team if they continue or are bothersome):
- Blurry vision
- Change in eye, eyelash, or eyelid color
- Dry eyes
- Eye irritation or itching
- Headache
- Increase in length, thickness, or number of eyelashes
- Sensitivity to light
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Pros and cons of Omlonti (omidenepag isopropyl)
Pros
- Works similarly well as latanoprost (Xalatan), another glaucoma eye drop
- Only used once per day
- Opened bottles can be stored at room temperature for up to 31 days
Cons
- Need to remove contact lenses before placing eye drops
- Can make your eyes more sensitive to light
- Can cause changes to eye color and eyelashes
Pharmacist tips for Omlonti (omidenepag isopropyl)
- Mark your appointments on your calendar to visit your optometrist or ophthalmologist. You'll need regular eye exams so that your eye specialist can check how well Omlonti (omidenepag isopropyl) is working for you and whether there are any side effects related to the eyes.
- Omlonti (omidenepag isopropyl) can cause blurry vision, dry eyes, and sensitivity to light. Don't drive until you realize how this medication affects your vision.
- Each bottle of Omlonti (omidenepag isopropyl) contains 2.5 mL of medication in a 5 mL bottle. Each bottle should last about 50 days when the eye drops are taken as prescribed (1 drop once per day).
- Keep the bottle and tip of Omlonti (omidenepag isopropyl) clean and free of bacteria (sterile). Don't touch the tip with your hands, to your eye, or to any other surface when using the eye drops. If you do, you can get bacteria into the bottle or on the bottle tip and contaminate it, which can cause eye infections if you use the medication afterwards. Make sure to keep the bottle capped and closed tightly when you're not using it.
- Store unopened bottles in the refrigerator. After opening, keep the bottles at room temperature for up to 31 days.
How to use Omlonti (omidenepag isopropyl):
- Wash your hands well with soap and water before you use Omlonti (omidenepag isopropyl) eye drops. Shake the bottle before you place the drop into your eye to mix the medication well.
- Tilt your head back so you're looking at the ceiling. Use your index (pointer) finger to pull your lower eyelid down to form a pocket.
- Gently squeeze 1 drop of Omlonti (omidenepag isopropyl) into the pocket. Then, close your eye and lightly press on the inside corner of your eye for 2 minutes. You can wipe away any extra liquid around the eye with a clean tissue.
- You might need to use more than one eye drop medications to help lower your eye pressure. Wait at least 5 minutes between each eye medication medication to give your eye(s) time to absorb each one.
Common questions about Omlonti (omidenepag isopropyl)
Ask your eye specialist whether Omlonti (omidenepag isopropyl) is available. This medication was initially approved by the FDA in 2022, and the manufacturer planned for it to become available in 2024. But it's unclear whether Omlonti (omidenepag isopropyl) is currently available. If this medication isn't yet on the market, your healthcare team can talk with you about other options for lowering eye pressure.
No, Omlonti (omidenepag isopropyl) isn't FDA approved to treat dry eyes. This medication is only approved to lower eye pressure in people who have open-angle glaucoma or ocular hypertension. In clinical studies, some people reported dry eyes as a side effect after using Omlonti (omidenepag isopropyl). If you have dry eyes, ask your eye specialist about options to treat your symptoms.
If you wear contact lenses, take them out before using Omlonti (omidenepag isopropyl). Then, wait at least 15 minutes after using the medication to put them back into your eye(s).
Yes, you can use other eye drops while you're on Omlonti (omidenepag isopropyl) treatment. But be sure to wait at least 5 minutes between the doses of each medication. This allows time for your eye to fully absorb each medication.
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Risks and warnings for Omlonti (omidenepag isopropyl)
Omlonti (omidenepag isopropyl) can cause some serious health issues. This risk may be even higher for certain groups. If this worries you, talk to your doctor or pharmacist about other options.
Only use in the eye
Only put Omlonti (omidenepag isopropyl) eye drops on the surface of the eye. Don't swallow the medication or use the suspension as an injection.
Darker eyes or eyelids
Omlonti (omidenepag isopropyl) can darken the color of your eyes and eyelids. This change in color happens because the medication causes the levels of melanin in your eyes to go up. Melanin is a protein that's responsible for the color of certain parts of your eyes.
The change in color might not be noticeable until after a few months or years of using Omlonti (omidenepag isopropyl). Color changes in the iris (the circular colored part of your eye) are most likely permanent. Your eyelashes and the skin around your eyes might also become darker, but this usually goes away after you stop using the medication. These side effects aren't known to be harmful, but it's best to check in with your eye provider regularly so they can make sure your eyes stay healthy.
Eyelash changes
During treatment with Omlonti (omidenepag isopropyl), it's possible for your eyelashes to grow in length or thickness. It can also make you have more eyelashes. These changes are typically reversible when you stop the medication.
Eye inflammation
- Risk factors: Active eye inflammation when using Omlonti (omidenepag isopropyl)
Prostaglandins like Omlonti (omidenepag isopropyl) can cause or worsen eye inflammation (redness and swelling). This is more likely to happen if you already have eye inflammation or if the lens of your eye is damaged or missing. Talk to your prescriber if you notice eye discomfort or changes in your vision while you're using Omlonti (omidenepag isopropyl).
Swelling of the retina (macular edema)
- Risk factors: History of eye problems (e.g., not having a lens inside your eye, having an artificial lens in your eye) | Age-related macular degeneration (AMD) | Genetic eye problems | Eye surgery | Using other medications that can cause macular edema
Omlonti (omidenepag isopropyl) can potentially cause swelling of the retina (also known as macular edema). In clinical studies, this eye condition happened in some people with an artificial lens in their eye(s) who used Omlonti (omidenepag isopropyl). Macular edema can cause changes in vision, such as blurry vision or dull color vision. Your prescriber might give you routine eye exams while taking Omlonti (omidenepag isopropyl) to check your eye health. Contact your prescriber if you notice any changes in vision while using the medication.
Risk of eye infection
Avoid touching the tip of the Omlonti (omidenepag isopropyl) bottle to your eyes when you're using the eye drops. Doing so can contaminate the eye drops and raise your risk of infection or eye injury.
Omlonti (omidenepag isopropyl) dosage
Eye dropper| Dosage | Quantity | Price as low as | Price per unit |
|---|---|---|---|
| 2.5ml of 0.002% | 1 eye dropper | $342.25 | $342.25 |
Typical dosage for Omlonti (omidenepag isopropyl)
Adults: The typical dose is 1 drop in the affected eye(s) once per day in the evening.
How much does Omlonti (omidenepag isopropyl) cost?
$342.25
What are alternatives to Omlonti (omidenepag isopropyl)?
Treatment of high pressure in the eye in adults with:
Omlonti (omidenepag isopropyl) images
