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Neupro

Neupro Side Effects

Robert Chad Hakim, PharmD, BCCCPKristianne Hannemann, PharmD
Reviewed by Robert Chad Hakim, PharmD, BCCCP, Kristianne Hannemann, PharmD
Last reviewed on January 7, 2025

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

Parkinson's disease

  • Nausea (28-48%)
  • Application site reaction (19-46%)
  • Sleepiness (12-32%)
  • Dizziness (14-23%)
  • Vomiting (8-20%)
  • Tiredness (6-18%)
  • Uncontrolled muscle movements (14-17%)
  • Trouble sleeping (6-14%)
  • Swelling in the arms and legs (2-14%)
  • Hallucinations (0-13%)
  • Joint pain (8-11%)
  • Excessive sweating (1-11%)
  • Headache (8-10%)

Restless leg syndrome

  • Application site reactions (23–43%)
  • Nausea (15–23%)
  • Headache (15–21%)
  • Fatigue and weakness (7-14%)
  • Sleepiness (5-10%)
  • Trouble sleeping (3-10%)

Less Common Side Effects

Parkinson's disease

  • Visual problems
  • Abnormal dreams
  • Indigestion
  • Constipation
  • Muscle spasms
  • Nasal and sinus congestion
  • Flu infection
  • Cough
  • Redness

Restless leg syndrome

  • Itching
  • Dizziness
  • Dry mouth
  • Excessive sweating
  • Vomiting
  • Constipation
  • Diarrhea
  • Weight gain

Neupro serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Excessive sleepiness: falling asleep during activities, falling asleep while driving, sudden sleep episodes, daytime sleepiness
  • Mental health changes: hallucinations, confusion, delusions, aggression, agitation
  • Impulsive behavior: strong urges to gamble, uncontrollable sexual urges, intense urges to spend money, binge eating
  • Serious withdrawal symptoms: fever, sweating, stiff muscles, confusion, not aware of your surroundings, fast or irregular heartbeat
  • Severe allergic reaction: hives, swelling in your face or tongue, trouble breathing

Source: DailyMed

The following Neupro side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

More common

Burning, itching, redness, skin rash, swelling, or soreness at the application site

swelling of the hands, ankles, feet, or lower legs

Less common

Bladder pain

bloody or cloudy urine

blurred vision or other changes in vision

difficult, burning, or painful urination

dizziness

frequent urge to urinate

headache

lower back or side pain

nervousness

pounding in the ears

seeing, hearing, or feeling things that are not there

slow or fast heartbeat

Get emergency help immediately if any of the following symptoms of overdose occur:

Symptoms of overdose

Confusion

convulsions

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

nausea

sweating

unusual tiredness or weakness

vomiting

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Sleepiness or unusual drowsiness

Less common

Acid or sour stomach

belching

difficulty having a bowel movement (stool)

difficulty with moving

dreaming abnormal

dry mouth

feeling of constant movement of self or surroundings

heartburn

indigestion

loss of appetite

muscle pain or stiffness

pain in the joints

sensation of spinning

sleeplessness

stomach discomfort, upset, or pain

trouble sleeping

unable to sleep

weight loss

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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Why trust our experts?

Robert Chad Hakim, PharmD, BCCCP, started his full-time career as a clinical pharmacist at UCLA Health in the general medicine, general cardiology, and ICU units after completing residency in 2016. He also was the preceptor for the general medicine rotation from 2017 to 2021, which was a required rotation for all pharmacy residents.
Kristianne Hannemann, PharmD, is a licensed pharmacist in California. She has been a retail pharmacy manager and staff pharmacist for over 7 years and has contributed drug information content to different health companies.

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