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Mustargen

mechlorethamine
Used for Leukemia, Hodgkin Lymphoma
Used for Leukemia, Hodgkin Lymphoma

Mustargen (mechlorethamine) is an injectable medication that's used to help relieve symptoms and improve quality of life in people with certain blood cancers, lung cancers, and cancers that have spread to other parts of the body. It has been discontinued by the manufacturer and is no longer available in the United States.

Reviewed by:
reviewer
Ally Tsai, PharmD
reviewer
Cydnee Ng, PharmD
Last reviewed on July 27, 2022
BasicsFAQsAlternativesPricesMedicare
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What is Mustargen (mechlorethamine)?

What is Mustargen (mechlorethamine) used for?

How Mustargen (mechlorethamine) works

Are you looking for information on Valchlor (mechlorethamine) instead?

Drug Facts

Common BrandsMustargen (brand no longer available)
Drug ClassAnticancer
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityDiscontinued
faqs

Frequently asked questions about Mustargen (mechlorethamine)

What is Mustargen (mechlorethamine)?
Mustargen (mechlorethamine) is an injectable medication used for the treatment of certain cancers that affect the bone marrow, blood, lymph nodes, skin, or lungs. It's given by a trained healthcare provider into a vein. This medication can also be injected into certain body areas with abnormal fluid collection caused by cancers that have spread. Mustargen (mechlorethamine) prevents cells from making copies of itself by damaging its DNA (deoxyribonucleic acid; genetic material). This helps slow or stop cell growth (especially cancer cells) in your body.
Is Mustargen (mechlorethamine) still available?
No, Mustargen (mechlorethamine) has been discontinued and is no longer available in the United States.
Why was Mustargen (mechlorethamine) discontinued?
The manufacturer (Recordati Rare Diseases) voluntarily discontinued Mustargen (mechlorethamine) in 2018 due to low demand of this medication. It wasn't taken off the market for safety concerns or lack of benefit.
What other medications can I use instead of Mustargen (mechlorethamine) for non-Hodgkin lymphoma?
Non-Hodgkin lymphoma (NHL) is a type of cancer that affects the lymphatic system, which includes the bone marrow and lymph nodes. There are many different factors that your provider must consider in choosing the right anticancer medication for you, such as the type and stage of cancer you have. Some alternative medications, such as cyclophosphamide (Cytoxan) and Leukeran (chlorambucil), work in a similar way to Mustargen (mechlorethamine). In addition to these medications, there are other types of treatment for non-Hodgkin lymphoma as well. Talk with your provider to determine a treatment plan that's best for you.
What's the difference between Mustargen (mechlorethamine) and Valchlor (mechlorethamine)?
Mustargen and Valchlor both contain mechlorethamine as the active ingredient, but they're not the same. One difference is what each medication is for. While Mustargen (mechlorethamine) can be used for many types of blood and lymph node cancers, Valchlor (mechlorethamine) is only used for mycosis fungoides, a type of lymphoma that affects the skin. Another difference is how you use each medication. Mustargen (mechlorethamine) is an injection that's given by a trained healthcare provider. On the other hand, Valchlor (mechlorethamine) is a gel that you apply as a thin layer onto the affected areas of your skin once daily. The last important difference is the availability of the medications. Mustargen (mechlorethamine) is no longer available in the United States, but Valchlor (mechlorethamine) is still available at specialty pharmacies. If you have questions on the differences between Mustargen (mechlorethamine) and Valchlor (mechlorethamine), talk to your provider or pharmacist.
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alternatives

What are alternatives to Mustargen (mechlorethamine)?

There are a number of medications that your doctor can prescribe in place of Mustargen (mechlorethamine). Compare a few possible alternatives below.
Mustargen (mechlorethamine)
Used for:
View Prices
Leukeran (chlorambucil)
Used for:

  • Chronic lymphocytic leukemia (CLL)

  • Hodgkin’s lymphoma (HL)

  • Other non-Hodgkin’s lymphomas

$6890.98 Lowest GoodRx priceView Prices
Cyclophosphamide
Used for:
$153.01 Lowest GoodRx priceView Prices

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