Skip to main content
Mexiletine

Mexiletine Side Effects

Ally Tsai, PharmDAllison Gourley, PharmD
Reviewed by Ally Tsai, PharmD, Allison Gourley, PharmD
Last reviewed on June 26, 2023

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

  • Nausea, vomiting, heartburn (40%)
  • Dizziness (19-26%)
  • Tremor (13%)
  • Nervousness (13%)

Less Common Side Effects

  • Lack of balance
  • Trouble sleeping
  • Blurry vision
  • Headache
  • Pounding chest
  • Chest pain

Mexiletine serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Severe allergic or skin reaction: rash, blistering or peeling of skin, hives, painful sores in your mouth or around your eyes, fever, trouble breathing, swollen lymph nodes
  • Low blood pressure or abnormal heart rhythm: chest pain or discomfort, weakness, dizziness, fainting
  • Heart failure: shortness of breath, swelling of feet or ankles, sudden weight gain, dizziness
  • Serious liver problems: nausea, vomiting, not feeling hungry, pain in the right side of the stomach, yellowing of the whites of the eyes or skin, dark-colored urine, light-colored stool

Source: DailyMed

The following Mexiletine side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur:

Less common

Chest pain

fast or irregular heartbeat

shortness of breath

Rare

Convulsions (seizures)

fever or chills

unusual bleeding or bruising

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Dizziness or lightheadedness

heartburn

nausea and vomiting

nervousness

trembling or shaking of the hands

unsteadiness or difficulty in walking

Less common

Blurred vision

confusion

constipation or diarrhea

headache

numbness or tingling of fingers and toes

ringing in the ears

skin rash

slurred speech

trouble in sleeping

unusual tiredness or weakness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

why trust our exports reliability shield

Why trust our experts?

Ally Tsai, PharmD
Reviewed by:
Ally Tsai, PharmD
Ally Tsai, PharmD, is a medication therapy management (MTM) pharmacist with 6 years of experience. As an MTM pharmacist, she helps people with complex medication regimens get the best results by conducting comprehensive medication reviews.
Allison Gourley, PharmD, is a kidney and pancreas transplant pharmacist at a teaching hospital in the San Francisco Bay Area. When she’s not educating patients about their immunosuppressants, she's actively involved in transplant research.

Was this page helpful?