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Methoxsalen

Methoxsalen Side Effects

Shifali Patel, PharmDAshley Wong, PharmD
Reviewed by Shifali Patel, PharmD, Ashley Wong, PharmD
Last reviewed on September 29, 2021

The following side effects may get better over time as your body gets used to the medication. Let your healthcare provider know immediately if you continue to experience these symptoms or if they worsen over time.

Common Side Effects

[[EDITOR|DRUG_DISPLAY_NAME|||title]] only:

  • Nausea (10%)

Combination of [[EDITOR|DRUG_DISPLAY_NAME]] and UVA radiation therapy:

  • Itching (10%)
  • Skin redness

Less Common Side Effects

[[EDITOR|DRUG_DISPLAY_NAME|||title]] only:

  • Nervousness
  • Difficulty sleeping (insomnia)
  • Depression

Combination of [[EDITOR|DRUG_DISPLAY_NAME]] and UVA radiation therapy:

  • Swelling (edema)
  • Dizziness
  • Headache
  • Weakness or discomfort
  • Depression
  • Loss of skin color
  • Skin blisters
  • Rash
  • Herpes
  • Heat rash
  • Hives
  • Inflammation of hair follicles
  • Stomach pain or discomfort
  • Leg cramps
  • Low blood pressure
  • Worsening psoriasis

Methoxsalen serious side effects

Contact your healthcare provider immediately if you experience any of the following.

  • Allergic reaction: itchy red rash (hives), shortness of breath, chest tightness, swelling of your lips, tongue, face, or eyes

Source: DailyMed

The following Methoxsalen side effects have also been reported

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Blistering and peeling of skin

reddened, sore skin

swelling, especially of the feet or lower legs

There is an increased risk of developing skin cancer after use of methoxsalen. You should check the treated areas of your body regularly and show your doctor any skin sores that do not heal, new skin growths, and skin growths that have changed in the way they look or feel.

Premature aging of the skin may occur as a result of prolonged methoxsalen therapy. This effect is permanent and is similar to the result of sunbathing for long periods of time.

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

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