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Lupaneta

Used for Endometriosis
Used for Endometriosis

Lupaneta (leuprolide / norethindrone) is a treatment that helps relieve endometriosis-related pain. There are two parts to this combination therapy: leuprolide injections in the muscle and norethindrone acetate tablets taken by mouth. It's no longer available in the United States because it was discontinued.

Reviewed by:
reviewer
Robert Chad Hakim, PharmD, BCCCP
reviewer
Kristianne Hannemann, PharmD
Last reviewed on January 19, 2023
BasicsFAQsAlternativesReferencesPricesMedicare
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What is Lupaneta (leuprolide / norethindrone)?

What is Lupaneta (leuprolide / norethindrone) used for?

  • Endometriosis

How Lupaneta (leuprolide / norethindrone) works

Are you looking for information on leuprolide (Lupron Depot) for prostate cancer or norethindrone (Aygestin) for endometriosis and irregular bleeding instead?

Drug Facts

Common BrandsLupaneta
Drug ClassGnRH agonist / Progestin
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityDiscontinued
faqs

Frequently asked questions about Lupaneta (leuprolide / norethindrone)

What is Lupaneta (leuprolide / norethindrone)?
Lupaneta (leuprolide / norethindrone) is a combination pack of leuprolide injections and norethindrone acetate tablets used to treat endometriosis. Leuprolide is a gonadotropin-releasing hormone (GnRH) agonist that stops your body from releasing estrogen to help relieve endometriosis-related pain. Norethindrone acetate is a progestin, which is a man-made version of the natural sex hormone progesterone. It lowers the risk of side effects, such as bone weakening and hot flashes, that leuprolide can cause.
Is Lupaneta (leuprolide / norethindrone) still available?
No, Lupaneta (leuprolide / norethindrone) has been discontinued and is no longer available in the United States. It's not clear why Lupaneta (leuprolide / norethindrone) has been discontinued.
What medications are used in place of Lupaneta (leuprolide / norethindrone)?
There are a number of medications that can be used for treating endometriosis. Leuprolide and norethindrone acetate, the active ingredients of Lupaneta (leuprolide / norethindrone), are also still available as separate medications today. If you have questions about treatment options for endometriosis, speak with your provider.
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alternatives

What are alternatives to Lupaneta (leuprolide / norethindrone)?

There are a number of medications that your doctor can prescribe in place of Lupaneta (leuprolide / norethindrone). Compare a few possible alternatives below.
Lupaneta (leuprolide / norethindrone)
Used for:

  • Endometriosis

View Prices
Norethindrone acetate (Aygestin)
Used for:
$20.53 Lowest GoodRx priceView Prices
Leuprolide (Lupron Depot)
Used for:

  • Endometriosis

  • Before fibroid surgery to help improve anemia due to bleeding from uterine fibroids

$226.62 Lowest GoodRx priceView Prices

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References

Best studies we found

AbbVie Inc. (2023). Lupaneta pack- leuprolide acetate and norethindrone acetate [package insert]. DailyMed.

Soliman, S. M., et al. (2016). Analysis of adherence, persistence, and surgery among endometriosis patients treated with leuprolide acetate plus norethindrone acetate add-back therapy. Journal of Managed Care & Specialty Pharmacy.

U.S. Food and Drug Administration. (n.d.). Drugs@FDA: FDA-approved drugs - Lupaneta pack.

GoodRx Health has strict sourcing policies and relies on primary sources such as medical organizations, governmental agencies, academic institutions, and peer-reviewed scientific journals. Learn more about how we ensure our content is accurate, thorough, and unbiased by reading our editorial guidelines.
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