FDA Issues Stronger Warning About Oral Nizoral (ketoconazole)

The FDA is recommending that Nizoral (ketoconazole) tablets not be used as a first-line treatment for any fungal infections, and not used at all to treat fungal skin or nail infections.

The oral tablets can cause liver and adrenal gland damage, and can have harmful interactions with other medications, prompting the FDA to approve a labeling change and to update the recommendations for use.

The warning is only for ketoconazole oral tablets, and does not apply to topical Nizoral or ketoconazole shampoos, creams, foams, gels, or other forms applied on the skin.

Talk to your doctor or pharmacist if you have any questions or concerns about Nizoral tablets, and you can find more information in the FDA Safety Alert here.

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Elizabeth Davis

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Tori Marsh, MPH

Tori Marsh is GoodRx’s resident expert on prescription drug pricing, prescribing trends, and drug savings. She oversees the GoodRx drug database, ensuring that all drug information is accurate and up to date.

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