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isonarif

Generic Rifamate
Used for Tuberculosis

Rifampin/isoniazid is a combination medication used to treat tuberculosis (TB). It's commonly used in the second phase of TB treatment after you've taken a different TB medication for the first 2 months of treatment. This medication is no longer available in the United States.

Reviewed by:
reviewerYen Nguyen, PharmD
reviewerKristianne Hannemann, PharmD
Last reviewed on January 3, 2022
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What is Rifampin/isoniazid?

Drug facts

Common Brands
Rifamate(brand no longer available)
Drug ClassAntitubercular agent
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityDiscontinued
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Common questions about Rifampin/isoniazid

Rifampin/isoniazid is a combination of two antibiotics. Rifampin and isoniazid work together to fight bacteria that's responsible for a lung infection called tuberculosis (TB).

No, rifampin/isoniazid is no longer available in the United States.

It's not clear why the manufacturer (Sanofi) decided to stop making rifampin/isoniazid, but it was discontinued as of June 2020. The separate ingredients (isoniazid and rifampin) are still available, but rifampin was reported to experience a shortage from their manufacturers as of December 2021.

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Rifampin/isoniazid dosage

Typical dosage for Rifampin/isoniazid

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Interactions between Rifampin/isoniazid and other drugs

Rifampin/isoniazid may interact with certain medications or supplements. Always let your doctor and pharmacist know about any other medications or supplements (including prescribed and over-the-counter medications, vitamins, and dietary or herbal supplements) that you are currently taking. The list below does not include all possible drug interactions with Rifampin/isoniazid. Please note that only the generic name of each medication is listed below.

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

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