Key takeaways:
Without insurance, 30 tablets of levothyroxine 50 mcg costs an average of $11.17, but the price may vary by location, pharmacy, and other factors.
GoodRx can help lower the cost of levothyroxine 50 mcg to as low as $4.00 per month at certain pharmacies.
Manufacturer copay savings cards or manufacturer prescription delivery programs may be able to help patients save money on certain brand-name versions of levothyroxine. There are usually requirements and restrictions with these types of savings programs.
The cost of levothyroxine can vary depending on many factors. This is true whether it’s generic or brand-name (Levoxyl, Euthyrox, Levo-T, Unithroid, Synthroid, and Tirosint, among others). But there are ways your patients can save money on their prescription, regardless of which one they’re getting. Most health insurance plans will cover levothyroxine, but for those without insurance, other options can help.
How much is levothyroxine?
Without insurance or discounts, 30 tablets of 50 mcg generic levothyroxine costs an average of $11.17. The average cost for the same amount of 88 mcg levothyroxine is $11.84.
Costs can vary, depending on which dose your patient is taking. Here are the average retail prices for 30 tablets of other available doses for generic levothyroxine tablets:
25 mcg: $11.34
75 mcg: $11.77
100 mcg: $11.12
112 mcg: $11.38
125 mcg: $11.42
137 mcg: $11.69
150 mcg: $11.85
175 mcg: $12.32
200 mcg: $12.19
300 mcg: $29.06
Factors that can affect the price of levothyroxine include:
Pharmacy
Insurance status
Brand name vs. generic
Quantity and dose
Eligibility for manufacturer copay savings cards and patient assistance programs
Does insurance cover levothyroxine?
Nearly all plans cover generic levothyroxine. About 99% of commercial plans and Medicare plans — and 100% of Affordable Care Act (ACA) plans — cover the generic medication. Medicaid also covers levothyroxine for 99.9% of enrollees, but about 5% need prior authorization before filling their prescription.
How different insurance plans cover generic levothyroxine
The table below shows the likelihood of having coverage for generic levothyroxine — as well as prior authorization and step therapy requirements — with different types of insurance plans.
Insurance type | Enrollees covered for levothyroxine 50 mcg tablets | Enrollees required to get prior authorization | Enrollees required to do step therapy |
|---|---|---|---|
100% | 0% | 1.7% | |
Commercial plans (excluding ACA plans) | 99.1% | 0% | 0.4% |
Medicare, including original Medicare and Medicare Advantage plans | 99.7% | 0% | 0% |
Medicaid, including state-run and managed care plans | 99.9% | 5.1% | 0% |
Source: Managed Markets Insight & Technology, LLC™, as of June 13, 2025. (See methodology below.)
Ways your patients can save money on levothyroxine
Regardless of insurance coverage, here are eight ways to save on levothyroxine.
1. Consider generic levothyroxine
Generic medications usually cost about 80% to 85% less than brand-name medications. For example, the average retail price for 30 tablets of 50 mcg Synthroid is $80.68. The same amount and dose of generic levothyroxine, on the other hand, costs around $11.17 on average.
It should be noted that the most recent ATA/AACE clinical guidelines advise against switching formulations, so clinical judgment is imperative. Recent data suggest switching between generic formulations may not significantly change TSH levels.
2. Use GoodRx
GoodRx coupons are free, and they can help save money, whether your patients have insurance or not. They can be downloaded through the app or via the website.
With a GoodRx coupon, the price of 30 tablets of 50 mcg generic levothyroxine may be as low as $4.00 at certain pharmacies.
Here’s the GoodRx price for other doses of generic levothyroxine tablets (prices for 30 tablets):
25 mcg: $4.00
75 mcg: $4.00
88 mcg: $4.00
100 mcg: $4.00
112 mcg: $4.00
125 mcg: $4.00
137 mcg: $4.00
150 mcg: $4.00
175 mcg: $4.00
200 mcg: $4.00
300 mcg: $14.70
GoodRx also offers exclusive discounts for patients paying cash for certain brand-name versions of levothyroxine. For example, your patients could access brand-name Tirosint or Tirosint-Sol for $99 per month. And they could get brand-name Levoxyl for $15 per month through GoodRx.
It’s best to share the coupon information with the pharmacy before purchasing, in order to avoid delays and get the best price. Consider sending GoodRx coupon information to the pharmacy at the same time as the patient’s prescription. You can also encourage your patient to tell the pharmacy they’ll be using a GoodRx coupon ahead of picking up their prescription.
Patients can also use GoodRx to compare prices between local pharmacies. This is important because many people are unaware that the prices for their medications can vary by pharmacy.
3. Use a manufacturer copay savings card
Manufacturer copay savings cards may be able to help patients save money on certain brand-name versions of levothyroxine. There are usually requirements and restrictions with these types of savings cards.
The following manufacturers provide savings cards for brand-name levothyroxine for those with commercial insurance. This list does not include all available savings offers.
Copay savings card | Offer | Restrictions |
|---|---|---|
A 30-day supply for as low as $25 or a 90-day supply for as low as $75 | This offer is not valid for those who receive coverage for prescription medications through a federal, state, or government-funded insurance program. Restrictions like monthly maximums may apply. | |
A 30-day supply for as low as $25 or a 90-day supply for as low as $60 | This offer is not valid for those who receive coverage for prescription medications through a federal, state, or government-funded insurance program. | |
A 30-day supply for as low as $3 | This offer is not valid for those who receive coverage for prescription medications through a federal, state, or government-funded insurance program. This offer can be used 18 times per calendar year or until the program expires. |
The manufacturer of Unithroid also offers an eVoucherRx program. There are no cards or coupons involved, and eligible participants get an automatic copay reduction at participating pharmacies.
4. Apply for a patient assistance program
Patient assistance programs (PAPs) help uninsured and underinsured people afford medications. For example, there’s a PAP for Tirosint-Sol. There’s also one for Tirosint, but it’s not currently open to new enrollees.
5. Consider prescription delivery programs
A few manufacturers of levothyroxine brands offer delivery programs to help eligible people save on the cost of these medications. For example:
Through the Synthroid Delivers Program a 90-day prescription may be as low as $25 a month. This program does not go through insurance.
Through the Unithroid at Your Door program, patients may be able to pay $28 for a 30-day prescription or $24 a month for a 90-day prescription. Insurance can’t be used with this program.
The Tirosint Direct Program offers individual pricing for patients who order from a network of participating mail-order pharmacies. This program works with or without insurance.
6. Prescribe a 90-day supply
A 90-day supply of medication can help patients save on medication price and copays. It’s important for the patient to check with the insurance plan first, and be mindful of prescription refill rules.
The bottom line
The average retail price for the generic version of levothyroxine is around $11.17 for thirty 50 mcg tablets. But the price your patients pay for medication may be higher or lower depending on pharmacy, location, and dosage. You can help them save money by using GoodRx, looking into manufacturer copay savings cards, and using prescription delivery programs.
Why trust our experts?
Methodology
We obtained national prescription coverage data for each medication from Managed Markets Insight & Technology (MMIT). The data reflects health insurance coverage as of June 2025.
We calculated the percentage of enrollees in plans that cover each medication by dividing the number of enrollees covered for the medication within a specific insurance channel (e.g., ACA, Medicare, Medicaid) by the total number of enrollees in all plans within that channel.
We determined the percentage of enrollees in plans with a prior authorization requirement by calculating the proportion of enrollees in plans that required prior authorization for the medication within each channel.
Finally, we measured the percentage of enrollees in plans with a step therapy requirement by calculating the proportion of enrollees in plans that imposed step therapy requirements for the medication in each channel.
These estimates, derived from national MMIT coverage data, provide insight into health insurance coverage for each medication. They take into account restrictions such as prior authorization, step therapy, and quantity limits. The percentages are expressed relative to the total number of enrollees covered by various insurance channels, including ACA plans, commercial (excluding ACA) plans, Medicare, and Medicaid (both state-run and managed care plans).
References
Brito, J. P., et al. (2022). Association between generic-to-generic levothyroxine switching and thyrotropin levels among US adults. JAMA Internal Medicine.
Garber, H. R., et al. (2012). Clinical practice guidelines for hypothyroidism in adults: Cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association. Endocrine Practice.
HealthWarehouse. (n.d.). Unithroid at Your Door prescription delivery program.
Liu, H., et al. (2022). Levothyroxine: Conventional and novel drug delivery formulations. Endocrine Reviews.
Medicaid.gov. (n.d.). Managed care.
RelayHealth. (n.d.). eVoucherRx search.
Synthroid. (n.d.). Support programs. AbbVie.
Tirosint-SOL. (n.d.). Patient assistance program. IBSA Pharma.
U.S. Food and Drug Administration. (2021). Generic drugs: Questions & answers.
