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Esimil

guanethidine and hydrochlorothiazide
Used for Hypertension

Esimil (guanethidine/hydrochlorothiazide) is a combination medication used to lower blood pressure. It's no longer available in the United States because it was discontinued.

Reviewed by:
reviewerRobert Chad Hakim, PharmD, BCCCP
reviewerAllison Gourley, PharmD
Last reviewed on June 29, 2022
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What is Esimil (guanethidine/hydrochlorothiazide)?

What is Esimil (guanethidine/hydrochlorothiazide) used for?

  • High blood pressure

Drug facts

Common BrandsEsimil(brand no longer available)
Drug ClassAdrenergic blocker / Diuretic
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityDiscontinued
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Common questions about Esimil (guanethidine/hydrochlorothiazide)

Esimil (guanethidine/hydrochlorothiazide) is made up of two medications that lower your blood pressure. Guanethidine is an adrenergic blocker that works by preventing release of certain chemicals that cause your blood vessels to constrict (tighten). This causes your blood vessels to open up, which lowers your blood pressure. Hydrochlorothiazide (Microzide) is a thiazide diuretic (water pill) that works in the kidneys to remove extra water, which lowers blood pressure and gets rid of swelling.

No, Esimil (guanethidine/hydrochlorothiazide) has been discontinued and is no longer available in the United States. It's not clear why Esimil (guanethidine/hydrochlorothiazide) has been discontinued.

Guanethidine as a single-ingredient medication has also been discontinued, but hydrochlorothiazide (Microzide) as a single-ingredient medication is one of many available medications commonly used today for the treatment of high blood pressure.

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Esimil (guanethidine/hydrochlorothiazide) dosage

Typical dosage for Esimil (guanethidine/hydrochlorothiazide)

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What are alternatives to Esimil (guanethidine/hydrochlorothiazide)?

There are a number of medications that your doctor can prescribe in place of Esimil (guanethidine/hydrochlorothiazide). Compare a few possible alternatives below.
Esimil (guanethidine/hydrochlorothiazide)
Used for:
  • High blood pressure
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Used for:
$4.00Lowest GoodRx priceView prices
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$27.81Lowest GoodRx priceView prices

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