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Esimil

guanethidine and hydrochlorothiazide
Used for Hypertension
Used for Hypertension

Esimil (guanethidine/hydrochlorothiazide) is a combination medication used to lower blood pressure. It's no longer available in the United States because it was discontinued.

Reviewed by:
reviewer
Robert Chad Hakim, PharmD, BCCCP
reviewer
Allison Gourley, PharmD
Last reviewed on June 29, 2022
BasicsFAQsAlternativesPricesMedicare
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What is Esimil (guanethidine/hydrochlorothiazide)?

What is Esimil (guanethidine/hydrochlorothiazide) used for?

  • High blood pressure

How Esimil (guanethidine/hydrochlorothiazide) works

Drug Facts

Common BrandsEsimil (brand no longer available)
Drug ClassAdrenergic blocker / Diuretic
Controlled Substance ClassificationNot a controlled medication
Generic StatusNo lower-cost generic available
AvailabilityDiscontinued
faqs

Frequently asked questions about Esimil (guanethidine/hydrochlorothiazide)

What is Esimil (guanethidine/hydrochlorothiazide)?
Esimil (guanethidine/hydrochlorothiazide) is made up of two medications that lower your blood pressure. Guanethidine is an adrenergic blocker that works by preventing release of certain chemicals that cause your blood vessels to constrict (tighten). This causes your blood vessels to open up, which lowers your blood pressure. Hydrochlorothiazide (Microzide) is a thiazide diuretic (water pill) that works in the kidneys to remove extra water, which lowers blood pressure and gets rid of swelling.
Is Esimil (guanethidine/hydrochlorothiazide) still available?
No, Esimil (guanethidine/hydrochlorothiazide) has been discontinued and is no longer available in the United States. It's not clear why Esimil (guanethidine/hydrochlorothiazide) has been discontinued.
What are examples of currently available medications that are used in place of Esimil (guanethidine/hydrochlorothiazide)?
Guanethidine as a single-ingredient medication has also been discontinued, but hydrochlorothiazide (Microzide) as a single-ingredient medication is one of many available medications commonly used today for the treatment of high blood pressure.
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alternatives

What are alternatives to Esimil (guanethidine/hydrochlorothiazide)?

There are a number of medications that your doctor can prescribe in place of Esimil (guanethidine/hydrochlorothiazide). Compare a few possible alternatives below.
Esimil (guanethidine/hydrochlorothiazide)
Used for:

  • High blood pressure

View Prices
Hydrochlorothiazide
Used for:

  • High blood pressure

  • Swelling in the body from fluids (edema), in addition to other medications

$3.00 Lowest GoodRx priceView Prices
Humalog (insulin lispro)
Used for:
$32.16 Lowest GoodRx priceView Prices

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